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Code & Data
SIFT for in-house use (version 4.0.2, released February 5, 2010) New!
Copyright code & exe (Sun, Linux)
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Prediction on human SNPs

Literature
Our review "Predicting the Effects of Amino Acid Substitutions on Protein Function" in Annual Review of Genomics and Human Genetics
Chapter
Supplementary Table 1
Referencing SIFT
Predicting Deleterious Amino Acid Substitutions, Genome Res. 2001 May; 11(5): 863.874. (Link)
Accounting for Human Polymorphisms Predicted to Affect Protein Function, Genome Res. 2002 December; 436-446 (Link)
SIFT: predicting amino acid changes that affect protein function, Nucleic Acids Research, 2003, Vol. 31, No. 13 3812-3814 (Link)
Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm, Nature Protocols 4, - 1073 - 1081 (2009) (Link)

SIFT predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. SIFT can be applied to naturally occurring nonsynonymous polymorphisms and laboratory-induced missense mutations.

Genome Tools New! | Tool Description/Input
1. Restrict to coding variants | Extract coding variants from a large list of genomic variants
2a. SIFT nonsynonymous single nucleotide variants (genome-scale) | Provides SIFT predictions for variants with genome coordinates
2b. Classify coding indels (Insertion / Deletion polymorphisms) | Indel variants in genome coordinates
Batch Tools | Tool Description/Input
SIFT Batch Protein | Multiple proteins identifiers
SIFT dbSNP | Multiple rsIDs (NCBI dbSNP)
Single Protein Tools | Tool Description/Input
SIFT BLink | Single protein (RefSeq ID /gi number)
SIFT Sequence | Single protein (Query sequence)
SIFT Related Sequences | Single protein (Query with related sequences)
SIFT Aligned Sequences | Single protein (Query with aligned sequences)

Other prediction tools for amino acid substitutions: PolyPhen , MAPP , SNPs3D

Page last modified: May 2009

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