Curriculum Vitae of Pauline Ng

PAULINE C. NG

Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, A1-162, Seattle, WA 98109 USA.

Telephone: (206) 667-4509; Fax: (206)667-5889; email: pauline@howard.fhcrc.org

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Interests

Bioinformatics tool development

Database searching methods

Improved substitution scoring matrices

Consequences of nonsynonymous polymorphisms

Education

Ph.D. Bioengineering University of Washington, Seattle WA. G.P.A. 3.9 1998-present

Dissertation: “PSSMs: Not just roadkill on the information superhighway”

Advisor: Steven Henikoff, Fred Hutchinson Cancer Research Center

B.Sc. Biology Caltech, Pasadena CA. G.P.A. 3.9 1993-1997

# Publications

Ng, P.C. and Henikoff, S. (2002) Accounting for human polymorphisms predicted to affect protein function. Genome Research, in press.

Ng P.C. and Henikoff, S. (2001) Predicting deleterious amino acid substitutions. Genome Research. 11:863-74.

Ng P.C., Henikoff J.G., and Henikoff, S. (2000) PHAT: a transmembrane-specific substitution matrix. Bioinformatics 16: 760-6.

Awards

Department of Energy Computational Science Graduate Fellowship 2000-present

Awarded to twenty graduate students in the United States.

National Science Foundation Fellowship 1998-2000

Scholarship winner, Keystone Symposia: Human Genetics and Genomics 2001

Tau Beta Pi Engineering Honor Society

Sigma Xi Research Society

Additional experience

Department of Energy practicum 2001

Dr. Natalia Maltsev, Math and Computer Science Division, Argonne National Laboratory

Cross-species comparison of the evolution of proteins in the purine and pyrimidine pathway.

Imaging Researcher 1997-1998

Prof. Scott Fraser, Biological Imaging Center, Caltech

Characterized novel two-photon dyes in living systems using two-photon and confocal

microscopy.

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Abstracts presented at national meetings

Ng, P.C. and Henikoff, S. SIFTing the human genome for damaging polymorphisms. Poster to be presented at HUGO Human Genome Meeting, Shanghai, China (upcoming in 2002).

Ng, P.C. and Henikoff, S. SIFT: A sequence-based tool for predicting deleterious amino acid substitutions. Poster presented at Keystone Symposia: Human Genetics and Genomics, Breckenridge CO (2001).

Ng, P.C., Henikoff, J.G., and Henikoff, S. PHAT: A transmembrane-specific substitution matrix. Poster presented at Intelligent Systems for Molecular Biology, U.C. San Diego (2000).

Teaching experience

Lecturer, Genotype to Phenotype workshop, Fred Hutchinson Cancer Research Center 2001

Educational Outreach Intern, Chevron, Richmond, CA. 1998

Designed laboratory setups and information sessions for high school students in the Chemathon,

an annual chemistry competition. Prepared lecture notes, tests, and slides.

Teaching Assistant, Undergraduate Biology Course, California Institute of Technology 1996

References

Steven Henikoff (advisor), Principal Investigator, Dept. of Basic Sciences, Fred Hutchinson Cancer Research Center. steveh@muller.fhcrc.org

Natalia Maltsev, Principal Investigator, Div. of Mathematics and Computer Science, Argonne National Laboratory. maltsev@mcs.anl.gov

Philip Green, Professor, Dept. of Genome Sciences, University of Washington. phg@u.washington.edu

Cornelia Ulrich, Assistant Professor, Dept. of Public Health Sciences, Fred Hutchinson Cancer Research Center. nulrich@fhcrc.org

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