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SIFT Batch Protein Analysis

# SIFT Batch

SIFT Batch: You can submit a list of RefSeq accession or gi IDs and their corresponding amino acid substitutions for prediction. If no amino acid substitution is listed, prediction for dbSNP nonsynonymous variants will be returned. Sequences are chosen from NCBI's precomputed BLAST searches. Either all BLAST hits can be used in the protein alignment or the top hit to each organism. Scoring is as described in Genome Research 12: 436-446.
You can also submit your protein sequence and related sequences or aligned sequences if you already have them.
Results are deleted after an hour, so please save them!
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Protein IDs
One RefSeq accession (starting with XP / NP) or gi number per line (Limit 1000 proteins, please!).
[Sample format]
Paste in RefSeq accessions or gi numbers
-or-
Upload file containing RefSeq accessions or gi numbers

Parameters
Select sequences to include:
If you receive a warning that the sequences were not diverse enough for prediction on your substitution, try "all BLAST hits". If that fails, you can submit here and have SIFT find the appropriate number of sequences.
Remove sequences more than percent identical to query
This cleans out any polymorphic alleles (sequences in the database that are nearly identical to your protein but already containing the substitutions of interest). The contaminating sequences may cause the substitution to be predicted as tolerated.