<?xml version="1.0" encoding="ISO-8859-1"?>
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/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<!--/******************************************************************************/
    	/* contains the parameters for DNA/DNA single mismatches of ;
	REF: Allawi and SantaLucia (1997). Biochemistry 36: 10581-10594. 
	REF: Allawi and SantaLucia (1998). Biochemistry 37: 2170-2179.
	REF: Allawi and SantaLucia (1998). Nuc Acids Res 26: 2694-2701. 
	REF: Allawi and SantaLucia (1998). Biochemistry 37: 9435-9444.
	REF: Peyret et al. (1999). Biochemistry 38: 3468-3477
    	/******************************************************************************/-->
			
		<data type="single_mismatch">
			<mismatch sequence="AA/AT">
               	<enthalpy>4700.0</enthalpy>
              	<entropy>12.9</entropy>
	    	</mismatch>
	    	<mismatch sequence="AC/AG">
	       		<enthalpy>-2900.0</enthalpy>
               	<entropy>-9.8</entropy>
	   		</mismatch>
	   		<mismatch sequence="AG/AC">
        		<enthalpy>-900.0</enthalpy>
                <entropy>-4.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="AT/AA">
	       		<enthalpy>1200.0</enthalpy>
               	<entropy>1.7</entropy>
	   		</mismatch>
    	   	<mismatch sequence="AA/CT">
	       		<enthalpy>7600.0</enthalpy>
             	<entropy>20.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="AC/CG">
	       		<enthalpy>-700.0</enthalpy>
               	<entropy>-3.8</entropy>
	   		</mismatch>
	   		<mismatch sequence="AG/CC">
        		<enthalpy>600.0</enthalpy>
                <entropy>-0.6</entropy>
	    	</mismatch>
	    	<mismatch sequence="AT/CA">
	       		<enthalpy>5300.0</enthalpy>
               	<entropy>14.6</entropy>
	   		</mismatch>            
    	   	<mismatch sequence="AA/GT">
	       		<enthalpy>3000.0</enthalpy>
               	<entropy>7.4</entropy>
	   		</mismatch> 
	    	<mismatch sequence="AC/GG">
	       		<enthalpy>500.0</enthalpy>
               	<entropy>3.2</entropy>
	   		</mismatch> 
	    	<mismatch sequence="AG/GC">
	       		<enthalpy>-4000.0</enthalpy>
               	<entropy>-13.2</entropy>
	    	</mismatch> 
	   		<mismatch sequence="AT/GA">
	       		<enthalpy>-700.0</enthalpy>
               	<entropy>-2.3</entropy>
	   		</mismatch>            
        	<mismatch sequence="TA/TT">
	       		<enthalpy>200.0</enthalpy>
               	<entropy>-1.5</entropy>
	    	</mismatch> 
	   		<mismatch sequence="TC/TG">
	       		<enthalpy>-2200.0</enthalpy>
               	<entropy>-8.4</entropy>
	   		</mismatch> 
    		<mismatch sequence="TG/TC">
	       		<enthalpy>-5000.0</enthalpy>
               	<entropy>-15.8</entropy>
	    	</mismatch> 
	   		<mismatch sequence="TT/TA">
	       		<enthalpy>-2700.0</enthalpy>
             	<entropy>-10.8</entropy>
	    	</mismatch>
	    	<mismatch sequence="TA/CT">
	       		<enthalpy>1200.0</enthalpy>
               	<entropy>0.7</entropy>
	    	</mismatch> 
	    	<mismatch sequence="TC/CG">
	       		<enthalpy>2300.0</enthalpy>
               	<entropy>5.4</entropy>
	   		</mismatch> 
	    	<mismatch sequence="TG/CC">
	       		<enthalpy>-800.0</enthalpy>
               	<entropy>-4.5</entropy>
	   		</mismatch> 
	   		<mismatch sequence="TT/CA">
        		<enthalpy>700.0</enthalpy>
               	<entropy>0.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="TA/GT">
	       		<enthalpy>-100.0</enthalpy>
               	<entropy>-1.7</entropy>
	    	</mismatch> 
	    	<mismatch sequence="TC/GG">
	       		<enthalpy>3300.0</enthalpy>
               	<entropy>10.4</entropy>
	    	</mismatch> 
	   		<mismatch sequence="TG/GC">
	       		<enthalpy>-4100.0</enthalpy>
               	<entropy>-11.7</entropy>
	   		</mismatch> 
    		<mismatch sequence="TT/GA">
	        	<enthalpy>1000.0</enthalpy>
              	<entropy>0.9</entropy>
	    	</mismatch>
	   		<mismatch sequence="CA/CT">
	       		<enthalpy>6100.0</enthalpy>
               	<entropy>16.4</entropy>
	    	</mismatch> 
	    	<mismatch sequence="CC/CG">
	       		<enthalpy>3600.0</enthalpy>
               	<entropy>8.9</entropy>
	   		</mismatch> 
	   		<mismatch sequence="CG/CC">
        		<enthalpy>-1500.0</enthalpy>
                <entropy>-7.2</entropy>
	    	</mismatch> 
	    	<mismatch sequence="CT/CA">
	       		<enthalpy>0.0</enthalpy>
              	<entropy>-4.4</entropy>
	    	</mismatch>
	    	<mismatch sequence="CA/AT">
	        	<enthalpy>3400.0</enthalpy>
               	<entropy>8.0</entropy>
	    	</mismatch> 
	    	<mismatch sequence="CC/AG">
	       		<enthalpy>5200.0</enthalpy>
               	<entropy>14.2</entropy>
	   		</mismatch> 
	    	<mismatch sequence="CG/AC">
	       		<enthalpy>1900.0</enthalpy>
               	<entropy>3.7</entropy>
	    	</mismatch> 
	   		<mismatch sequence="CT/AA">
	       		<enthalpy>2300.0</enthalpy>
              	<entropy>4.6</entropy>
	    	</mismatch>
	    	<mismatch sequence="CA/TT">
	       		<enthalpy>1000.0</enthalpy>
               	<entropy>0.7</entropy>
	    	</mismatch> 
	   		<mismatch sequence="CC/TG">
	       		<enthalpy>5200.0</enthalpy>
               	<entropy>13.5</entropy>
	   		</mismatch> 
	    	<mismatch sequence="CG/TC">
	       		<enthalpy>-1500.0</enthalpy>
               	<entropy>-6.1</entropy>
	   		</mismatch> 
	    	<mismatch sequence="CT/TA">
	       		<enthalpy>-1200.0</enthalpy>
             	<entropy>-6.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="GA/GT">
	        	<enthalpy>1600.0</enthalpy>
                <entropy>3.6</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GC/GG">
	       		<enthalpy>-6000.0</enthalpy>
               	<entropy>-15.8</entropy>
	    	</mismatch> 
	   		<mismatch sequence="GG/GC">
	       		<enthalpy>-4900.0</enthalpy>
               	<entropy>-15.3</entropy>
	   		</mismatch> 
	    	<mismatch sequence="GT/GA">
	       		<enthalpy>-3100.0</enthalpy>
             	<entropy>-9.5</entropy>
	    	</mismatch>
	    	<mismatch sequence="GA/AT">
	       		<enthalpy>700.0</enthalpy>
               	<entropy>0.7</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GC/AG">
	       		<enthalpy>-600.0</enthalpy>
               	<entropy>-1.0</entropy>
	    	</mismatch> 
	   		<mismatch sequence="GG/AC">
	       		<enthalpy>-700.0</enthalpy>
               	<entropy>-2.3</entropy>
	    	</mismatch> 
	   		<mismatch sequence="GT/AA">
	       		<enthalpy>-600.0</enthalpy>
             	<entropy>-2.3</entropy>
	    	</mismatch>
	    	<mismatch sequence="GA/TT">
	       		<enthalpy>-1300.0</enthalpy>
                <entropy>-5.3</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GC/TG">
	       		<enthalpy>-4400.0</enthalpy>
               	<entropy>-12.3</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GG/TC">
	       		<enthalpy>-2800.0</enthalpy>
               	<entropy>-8.0</entropy>
	   		</mismatch> 
	   		<mismatch sequence="GT/TA">
        		<enthalpy>-2500.0</enthalpy>
               	<entropy>-8.3</entropy>
	    	</mismatch>
	    </data>