<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
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/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
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/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<!--/******************************************************************************/
    	/* contains the parameters for RNA/RNA internal loop of ;
	REF: Douglas M Turner et al (2006). Nucleic Acids Research 34: 4912-4924. 
    REF: Douglas M Turner et al (1999). J.Mol.Biol.  288: 911_940 
    	/******************************************************************************/-->
 			
 		<data type="long_mismatch">
 			<mismatch size="2" type="initiation">
 				<enthalpy>-10500.0</enthalpy>
 				<entropy>-35.4</entropy>
 			</mismatch>
 			<mismatch size="3" type="initiation">
 				<enthalpy>300.0</enthalpy>
 				<entropy>-4.5</entropy>
 			</mismatch>
 			<mismatch size="4" type="initiation">
 				<enthalpy>-7200.0</enthalpy>
				<entropy>-26.8</entropy>
 			</mismatch>
 			<mismatch size="5" type="initiation">
 				<enthalpy>-6800.0</enthalpy>
 				<entropy>-28.4</entropy>
 			</mismatch>
 			<mismatch size="6" type="initiation">
 				<enthalpy>-1300.0</enthalpy>
 				<entropy>-10.6</entropy>
 			</mismatch>
 			<mismatch size=">6" type="initiation">
 				<enthalpy>-1300.0</enthalpy>
 				<entropy>-10.6</entropy>
 			</mismatch>
 			
 			<closure type="per_A/U">
 				<enthalpy>5000.0</enthalpy>
 				<entropy>13.9</entropy>
 			</closure>
 			
 			<closure type="per_G/U">
 				<enthalpy>5000.0</enthalpy>
 				<entropy>13.9</entropy>
 			</closure>
 			
 			<asymetry>
 				<enthalpy>3200.0</enthalpy>
 				<entropy>8.4</entropy>
 			</asymetry>
 			
 			<mismatch sequence="RA/YG" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RA/YG" loop="1xn_n>2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RA/YG" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RA/YG" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-3400.0</enthalpy>
 				<entropy>-8.4</entropy>
 			</mismatch>

 			<mismatch sequence="YA/RG" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.8</entropy>
 			</mismatch>
 			<mismatch sequence="YA/RG" loop="1xn_n>2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="YA/RG" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-5700.0</enthalpy>
 				<entropy>-4.1</entropy>
 			</mismatch>
 			<mismatch sequence="YA/RG" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-3400</enthalpy>
 				<entropy>-8.4</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.8</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="1xn_n>2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-10900.0</enthalpy>
 				<entropy>-31.3</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-7600.0</enthalpy>
 				<entropy>-21.3</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.8</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="1xn_n>2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-8600.0</enthalpy>
 				<entropy>-24.2</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-7600.0</enthalpy>
 				<entropy>-21.3</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1x1" type="first_non_canonical_pair">
 				<enthalpy>-7900.0</enthalpy>
 				<entropy>-17.1</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.8</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1xn_n>2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-9000.0</enthalpy>
 				<entropy>-26.8</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>2800.0</enthalpy>
 				<entropy>12.3</entropy>
 			</mismatch> 			
 			<mismatch sequence="U/U" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-10100.0</enthalpy>
 				<entropy>-30.0</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="1xn_n>2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-6400.0</enthalpy>
 				<entropy>-19.4</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-16.8</entropy>
 			</mismatch>
 			<mismatch sequence="RU/YU" loop="1x1" type="first_non_canonical_pair">
 				<enthalpy>-3400.0</enthalpy>
 				<entropy>-9.7</entropy>
 			</mismatch>
 		</data>
