<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
/*       it under the terms of the GNU General Public License as published by */
/*       the Free Software Foundation; either version 2 of the License, or    */
/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
/*       MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU    */
/*       General Public License for more details.                             */

/*       You should have received a copy of the GNU General Public License    */
/*       along with this program; if not, write to the Free Software          */
/*       Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307 */
/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<hybridization type="dnadna">
  <modified_nucleotid type="inosine">
    <origine article="Santalucia_2005">
    <!--/******************************************************************************/
    /* contains the parameters for DNA/DNA hybridisation with inosine pairs of Santalucia et al.      */
    /* (2005). Nucleic acids research 33 : 6258-6267                              */
    /******************************************************************************/-->
        <modified sequence="AA/IT">
            <enthalpy>-3400.0</enthalpy>
            <entropy>-11.2</entropy>
	    </modified>
	    <modified sequence="AC/IG">
	        <enthalpy>-7800.0</enthalpy>
            <entropy>-21.1</entropy>
	    </modified>
	    <modified sequence="AG/IC">
	        <enthalpy>2600.0</enthalpy>
            <entropy>8.9</entropy>
	    </modified>
	    <modified sequence="AT/IA">
	        <enthalpy>-8300.0</enthalpy>
            <entropy>-25.0</entropy>
	    </modified>
	    <modified sequence="AI/IA">
            <enthalpy>-9500.0</enthalpy>
            <entropy>-29.1</entropy>
       	</modified>           
        <modified sequence="CA/IT">
            <enthalpy>-5900.0</enthalpy>
            <entropy>-17.4</entropy>
	    </modified>
	    <modified sequence="CC/IG">
	        <enthalpy>-6800.0</enthalpy>
            <entropy>-19.1</entropy>
	    </modified>
	    <modified sequence="CG/IC">
	        <enthalpy>-5400.0</enthalpy>
            <entropy>-13.7</entropy>
	    </modified>
	    <modified sequence="CT/IA">
	        <enthalpy>-8900.0</enthalpy>
            <entropy>-25.5</entropy>
	    </modified>
	    <modified sequence="CI/IC">
	         <enthalpy>-1800.0</enthalpy>
             <entropy>-6.4</entropy> 
        </modified>	
        <modified sequence="GA/IT">
            <enthalpy>-1900.0</enthalpy>
            <entropy>-8.5</entropy>
	    </modified>
	    <modified sequence="GC/IG">
	         <enthalpy>-1100.0</enthalpy>
             <entropy>-3.2</entropy>
	    </modified>
	    <modified sequence="GG/IC">
	        <enthalpy>7100.0</enthalpy>
            <entropy>21.3</entropy>
	    </modified>
	    <modified sequence="GT/IA">
	        <enthalpy>-4900.0</enthalpy>
            <entropy>-15.8</entropy>
	    </modified>
	    <modified sequence="GI/IG">
	       	<enthalpy>-4200.0</enthalpy>
            <entropy>-39.8</entropy>  
        </modified>
        <modified sequence="TA/IT">
            <enthalpy>-6500.0</enthalpy>
            <entropy>-22.0</entropy>
	    </modified>
	    <modified sequence="TC/IG">
	        <enthalpy>-3500.0</enthalpy>
            <entropy>-10.6</entropy>
	    </modified>
	    <modified sequence="TG/IC">
	        <enthalpy>-1000.0</enthalpy>
            <entropy>-2.4</entropy>
	    </modified>
	    <modified sequence="TT/IA">
	        <enthalpy>490.0</enthalpy>
            <entropy>-0.7</entropy>
	    </modified>
	    <modified sequence="TI/IT">
	        <enthalpy>-14700.0</enthalpy>
            <entropy>-49.4</entropy>
		</modified>	        
	    <modified sequence="IA/AT">
            <enthalpy>-1300.0</enthalpy>
            <entropy>-4.6</entropy>
	    </modified>
	    <modified sequence="IC/AG">
	        <enthalpy>-7600.0</enthalpy>
            <entropy>-20.2</entropy>
	    </modified>
	    <modified sequence="IG/AC">
	        <enthalpy>-7000.0</enthalpy>
            <entropy>-20.0</entropy>
	    </modified>
	    <modified sequence="IT/AA">
	        <enthalpy>-700.0</enthalpy>
            <entropy>-2.6</entropy>
	    </modified>
	    <modified sequence="IA/AI">
	        <enthalpy>-13900.0</enthalpy>
            <entropy>-40.5</entropy>
        </modified>            
        <modified sequence="IA/CT">
            <enthalpy>-4900.0</enthalpy>
            <entropy>-13.9</entropy>
	    </modified>
	    <modified sequence="IC/CG">
	         <enthalpy>-5000.0</enthalpy>
             <entropy>-12.6</entropy>
	    </modified>
	    <modified sequence="IG/CC">
	        <enthalpy>-8300.0</enthalpy>
            <entropy>-23.8</entropy>
	    </modified>
	    <modified sequence="IT/CA">
	        <enthalpy>-8800.0</enthalpy>
            <entropy>-25.4</entropy>
	    </modified>
	    <modified sequence="IC/CI">
	        <enthalpy>-12100.0</enthalpy>
            <entropy>-36.3</entropy>
        </modified>	
        <modified sequence="IA/GT">
            <enthalpy>1000.0</enthalpy>
            <entropy>1.0</entropy>
	    </modified>
	    <modified sequence="IC/GG">
	        <enthalpy>-7600.0</enthalpy>
            <entropy>-22.0</entropy>
	    </modified>
	    <modified sequence="IG/GC">
	        <enthalpy>5800.0</enthalpy>
            <entropy>16.9</entropy>
	    </modified>
	    <modified sequence="IT/GA">
	        <enthalpy>100.0</enthalpy>
            <entropy>-1.0</entropy>
	    </modified>
	    <modified sequence="IG/GI">
	        <enthalpy>3200.0</enthalpy>
            <entropy>6.1</entropy>
        </modified>        
        <modified sequence="IA/TT">
            <enthalpy>-800.0</enthalpy>
            <entropy>-4.3</entropy>
	    </modified>
	    <modified sequence="IC/TG">
	        <enthalpy>-4300.0</enthalpy>
            <entropy>-12.1</entropy>
	    </modified>
	    <modified sequence="IG/TC">
	        <enthalpy>100.0</enthalpy>
            <entropy>-1.0</entropy>
	    </modified>
	    <modified sequence="IT/TA">
	        <enthalpy>-6000.0</enthalpy>
            <entropy>-18.7</entropy>
	    </modified>
	    <modified sequence="IT/TI">
	        <enthalpy>-7600.0</enthalpy>
            <entropy>-31.1</entropy>
	    </modified>
	    <modified sequence="IC/IG">
	         <enthalpy>-12100.0</enthalpy>
             <entropy>-36.3</entropy>
	    </modified>
	    <modified sequence="IG/IC">
	        <enthalpy>1300.0</enthalpy>
            <entropy>3.0</entropy>
	    </modified>
	    <modified sequence="IT/IA">
	        <enthalpy>-3300.0</enthalpy>
            <entropy>-11.9</entropy>
	    </modified>
	    <modified sequence="IA/IT">
	        <enthalpy>100.0</enthalpy>
            <entropy>-2.3</entropy>
        </modified>    
    </origine>
  </modified_nucleotid>
  
  <modified_nucleotid type="2_hydroxyadenine">
  	<origine article="Sugimoto_2001">
  	 <!--/******************************************************************************/
    /* contains the parameters for DNA/DNA hybridisation with 2_hydroxyadenine pairs of Sugimoto et al.      */
    /* (2001). Nucleic acids research 29 : 3289-3296                              */
    /******************************************************************************/-->
  		<modified sequence="TAA/AA*T">
  			<enthalpy>26500.0</enthalpy>
  			<entropy>71.0</entropy>
  		</modified>
  		<modified sequence="TGA/AA*T">
  			<enthalpy><21000.0/enthalpy>
  			<entropy>61.0</entropy>
  		</modified>
  		<modified sequence="TCA/AA*T">
  			<enthalpy>9000.0</enthalpy>
  			<entropy>27.0</entropy>
  		</modified>
  		<modified sequence="TTA/AA*T">
  			<enthalpy>14000.0</enthalpy>
  			<entropy>38.0</entropy>
  		</modified>
  		<modified sequence="GAC/CA*G">
  			<enthalpy>70800.0</enthalpy>
  			<entropy>203.0</entropy>
  		</modified>
  		<modified sequence="GGC/CA*G">
  			<enthalpy>25600.0</enthalpy>
  			<entropy>76.0</entropy>
  		</modified>
  		<modified sequence="GCC/CA*G">
  			<enthalpy>19000.0</enthalpy>
  			<entropy>54.0</entropy>
  		</modified>
  		<modified sequence="GTC/CA*G">
  			<enthalpy>9000.0</enthalpy>
  			<entropy>29.0</entropy>
  		</modified>  		
  		<modified sequence="CTA*A/AT" sens="5">
  			<enthalpy>6.0</enthalpy>
  			<entropy>18.0</entropy>
  		</modified>				
  		<modified sequence="TGA*C/AG" sens="5">
  			<enthalpy>76600.0</enthalpy>
  			<entropy>227.0</entropy>
  		</modified>
  		<modified sequence="CTA*A/GT" sens="5">
  			<enthalpy>48.3</enthalpy>
  			<entropy>144.0</entropy>
  		</modified>	
  		<modified sequence="TGA*C/GG" sens="5">
  			<enthalpy>21000.0</enthalpy>
  			<entropy>63.0</entropy>
  		</modified>
  		<modified sequence="CTA*A/CT" sens="5">
  			<enthalpy>15600.0</enthalpy>
  			<entropy>45.0</entropy>
  		</modified>	
  		<modified sequence="TGA*C/CG" sens="5">
  			<enthalpy>37000.0</enthalpy>
  			<entropy>110.0</entropy>
  		</modified>
  		<modified sequence="CTA*A/TT" sens="5">
  			<enthalpy>-4000.0</enthalpy>
  			<entropy>-13.0</entropy>
  		</modified>
  		<modified sequence="TGA*C/TG" sens="5">
  			<enthalpy>15000.0</enthalpy>
  			<entropy>47.0</entropy>
  		</modified>
  	</origine>	
  </modified_nucleotid>
  
  <modified_nucleotid type="azobenzene">
  	<origine article="Asanuma_2005">
  	 <!--/******************************************************************************/
    /* contains the parameters for DNA/DNA hybridisation with azobenzenes of Asanuma et al.      */
    /* (2005). Nucleic acids Symposium Series 49 : 35-36                              */
    /******************************************************************************/-->
  		<modified sequence="AxA/TT_trans">
  			<enthalpy>-13000.0</enthalpy>
  			<entropy>-35.4</entropy>
  		</modified>
  		<modified sequence="TxA/AT_trans">
  			<enthalpy>-7500.0</enthalpy>
  			<entropy>-19.0</entropy>
  		</modified>
  		<modified sequence="GxA/CT_trans">
  			<enthalpy><-10400.0/enthalpy>
  			<entropy>-27.1</entropy>
  		</modified>
  		<modified sequence="CxA/GT_trans">
  			<enthalpy><-10300.0/enthalpy>
  			<entropy>-25.9</entropy>
  		</modified>
  		<modified sequence="AxA/TT_cis">
  			<enthalpy>4800.0</enthalpy>
  			<entropy>13.5</entropy>
  		</modified>
  		<modified sequence="TxA/AT_cis">
  			<enthalpy>-4200.0</enthalpy>
  			<entropy>-14.8</entropy>
  		</modified>
  		<modified sequence="GxA/CT_cis">
  			<enthalpy><300.0/enthalpy>
  			<entropy>0.2</entropy>
  		</modified>
  		<modified sequence="CxA/GT_cis">
  			<enthalpy><-1700.0/enthalpy>
  			<entropy>-5.1</entropy>
  		</modified> 		
  		<modified sequence="AxT/TA_trans">
  			<enthalpy>-5000.0</enthalpy>
  			<entropy>13.2</entropy>
  		</modified>
  		<modified sequence="TxT/AA_trans">
  			<enthalpy>600.0</enthalpy>
  			<entropy>3.8</entropy>
  		</modified>
  		<modified sequence="GxT/CA_trans">
  			<enthalpy><1500.0/enthalpy>
  			<entropy>7.6</entropy>
  		</modified>
  		<modified sequence="CxT/GA_trans">
  			<enthalpy><-4300.0/enthalpy>
  			<entropy>-9.6</entropy>
  		</modified>
  		<modified sequence="AxT/TA_cis">
  			<enthalpy>21500.0</enthalpy>
  			<entropy>63.7</entropy>
  		</modified>
  		<modified sequence="TxT/AA_cis">
  			<enthalpy>25800.0</enthalpy>
  			<entropy>78</entropy>
  		</modified>
  		<modified sequence="GxT/CA_cis">
  			<enthalpy><22700.0/enthalpy>
  			<entropy>67.6</entropy>
  		</modified>
  		<modified sequence="CxT/GA_cis">
  			<enthalpy><20100.0/enthalpy>
  			<entropy>60.0</entropy>
  		</modified>
  		<modified sequence="AxG/TC_trans">
  			<enthalpy>-10200.0</enthalpy>
  			<entropy>-25.7</entropy>
  		</modified>
  		<modified sequence="TxG/AC_trans">
  			<enthalpy>-2800.0</enthalpy>
  			<entropy>-3.0</entropy>
  		</modified>
  		<modified sequence="GxG/CC_trans">
  			<enthalpy><-5500.0/enthalpy>
  			<entropy>-10.8</entropy>
  		</modified>
  		<modified sequence="CxG/GC_trans">
  			<enthalpy><-10300.0/enthalpy>
  			<entropy>-24.8</entropy>
  		</modified>
  		<modified sequence="AxG/TC_cis">
  			<enthalpy>-8900.0</enthalpy>
  			<entropy>-29.4</entropy>
  		</modified>
  		<modified sequence="TxG/AC_cis">
  			<enthalpy>10700.0</enthalpy>
  			<entropy>33.5</entropy>
  		</modified>
  		<modified sequence="GxG/CC_cis">
  			<enthalpy><11900.0/enthalpy>
  			<entropy>36.5</entropy>
  		</modified>
  		<modified sequence="CxG/GC_cis">
  			<enthalpy><2700.0/enthalpy>
  			<entropy>9.2</entropy>
  		</modified>  		
  		<modified sequence="AxC/GG_trans">
  			<enthalpy>-900.0</enthalpy>
  			<entropy>0.1</entropy>
  		</modified>
  		<modified sequence="TxC/AG_trans">
  			<enthalpy>-2700.0</enthalpy>
  			<entropy>-4.7</entropy>
  		</modified>
  		<modified sequence="GxC/CG_trans">
  			<enthalpy><-2900.0/enthalpy>
  			<entropy>-4.3</entropy>
  			</modified>
  		<modified sequence="CxC/GG_trans">
  			<enthalpy><-6600.0/enthalpy>
  			<entropy>-15.0</entropy>
  		</modified>
  		<modified sequence="AxC/TG_cis">
  			<enthalpy>1700.0</enthalpy>
  			<entropy>2.9</entropy>
  		</modified>
  		<modified sequence="TxC/AG_cis">
  			<enthalpy>1500.0</enthalpy>
  			<entropy>2.9</entropy>
  		</modified>
  		<modified sequence="GxC/CG_cis">
  			<enthalpy><11400.0/enthalpy>
  			<entropy>34.6</entropy>
  		</modified>
  		<modified sequence="CxC/GG_cis">
  			<enthalpy><18300.0/enthalpy>
  			<entropy>56.0</entropy>
  		</modified>
  	</origine>	
  </modified_nucleotid>
  
  <modified_nucleotid type="locked_acid_nucleic">
  	<origine article="McTigue_2004">
  	 <!--/******************************************************************************/
    /* contains the parameters for DNA/DNA hybridisation with locked acid nucleic of McTigue et al.      */
    /* (2004). Biochemistry 43 : 5388-5405                              */
    /******************************************************************************/-->
  		<modified type="increment" sequence="AlA/TT">
  			<enthalpy>707.0</enthalpy>
  			<entropy>2.5</entropy>
  		</modified>
  		<modified type="increment" sequence="AlT/TA">
  			<enthalpy>2282.0</enthalpy>
  			<entropy>7.5</entropy>
  		</modified>
  		<modified type="increment" sequence="AlG/TC">
  			<enthalpy><264.0/enthalpy>
  			<entropy>2.6</entropy>
  		</modified>
  		<modified type="increment" sequence="AlC/TG">
  			<enthalpy><1131.0/enthalpy>
  			<entropy>4.1</entropy>
  		</modified>  		
  		<modified type="increment" sequence="TlA/AT">
  			<enthalpy>-46.0</enthalpy>
  			<entropy>1.6</entropy>
  		</modified>
  		<modified type="increment" sequence="TlT/AA">
  			<enthalpy>1528.0</enthalpy>
  			<entropy>5.3</entropy>
  		</modified>
  		<modified type="increment" sequence="TlG/AC">
  			<enthalpy><-1540.0/enthalpy>
  			<entropy>-3.0</entropy>
  		</modified>
  		<modified type="increment" sequence="TlC/AG">
  			<enthalpy><1893.0/enthalpy>
  			<entropy>6.7s</entropy>
  		</modified> 		
  		<modified type="increment" sequence="GlA/CT">
  			<enthalpy>3162.0</enthalpy>
  			<entropy>10.5</entropy>
  		</modified>
  		<modified type="increment" sequence="GlT/CA">
  			<enthalpy>-212.0</enthalpy>
  			<entropy>0.1</entropy>
  		</modified>
  		<modified type="increment" sequence="GlG/CC">
  			<enthalpy><-2844.0/enthalpy>
  			<entropy>-6.7</entropy>
  		</modified>
  		<modified type="increment" sequence="GlC/CG">
  			<enthalpy><-360.0/enthalpy>
  			<entropy>-0.3</entropy>
  		</modified> 		
  		<modified type="increment" sequence="ClA/GT">
  			<enthalpy>1049.0</enthalpy>
  			<entropy>4.3</entropy>
  		</modified>
  		<modified type="increment" sequence="ClT/GA">
  			<enthalpy>708.0</enthalpy>
  			<entropy>4.2</entropy>
  		</modified>
  		<modified type="increment" sequence="ClG/GC">
  			<enthalpy><785.0/enthalpy>
  			<entropy>3.7</entropy>
  		</modified>
  		<modified type="increment" sequence="Cl/GG">
  			<enthalpy><2096.0/enthalpy>
  			<entropy>8.0</entropy>
  		</modified>  		
  		<modified type="increment" sequence="AAl/TT">
  			<enthalpy>992.0</enthalpy>
  			<entropy>74.1</entropy>
  		</modified>
  		<modified type="increment" sequence="ATl/TA">
  			<enthalpy>1816.0</enthalpy>
  			<entropy>6.9</entropy>
  		</modified>
  		<modified type="increment" sequence="AGl/TC">
  			<enthalpy><-1200.0/enthalpy>
  			<entropy>-1.8</entropy>
  		</modified>
  		<modified type="increment" sequence="ACl/TG">
  			<enthalpy><2890.0/enthalpy>
  			<entropy>10.6</entropy>
  		</modified>  		
  		<modified type="increment" sequence="TAl/AT">
  			<enthalpy>1591.0</enthalpy>
  			<entropy>5.3</entropy>
  		</modified>
  		<modified type="increment" sequence="TTl/AA">
  			<enthalpy>2326.0</enthalpy>
  			<entropy>8.1</entropy>
  		</modified>
  		<modified type="increment" sequence="TGl/AC">
  			<enthalpy><2165.0/enthalpy>
  			<entropy>7.2</entropy>
  		</modified>
  		<modified type="increment" sequence="TCl/AG">
  			<enthalpy><609.0/enthalpy>
  			<entropy>3.2</entropy>
  		</modified> 		
  		<modified type="increment" sequence="GAl/CT">
  			<enthalpy>444.0</enthalpy>
  			<entropy>2.9</entropy>
  		</modified>
  		<modified type="increment" sequence="GTl/CA">
  			<enthalpy>-635.0</enthalpy>
  			<entropy>-0.3</entropy>
  		</modified>
  		<modified type="increment" sequence="GGl/CC">
  			<enthalpy><-943.0/enthalpy>
  			<entropy>-0.9</entropy>
  		</modified>
  		<modified type="increment" sequence="GCl/CG">
  			<enthalpy><-925.0/enthalpy>
  			<entropy>-1.1</entropy>
  		</modified> 		
  		<modified type="increment" sequence="CAl/GT">
  			<enthalpy>1358.0</enthalpy>
  			<entropy>4.4</entropy>
  		</modified>
  		<modified type="increment" sequence="CTl/GA">
  			<enthalpy>-1671.0</enthalpy>
  			<entropy>-4.1</entropy>
  		</modified>
  		<modified type="increment" sequence="CGl/GC">
  			<enthalpy><-276.0/enthalpy>
  			<entropy>-0.7</entropy>
  		</modified>
  		<modified type="increment" sequence="CCl/GG">
  			<enthalpy><2063.0/enthalpy>
  			<entropy>7.6</entropy>
  		</modified>
  	</origine>
  </modified_nucleotid>
  
  <modified_nucleotid type="L_deoxyadenosine">
  	<origine article="Sugimoto_2005">
  	 <!--/******************************************************************************/
    /* contains the parameters for DNA/DNA hybridisation with L_deoxyadenosine of Sugimoto et al.      */
    /* (2005). Analytical sciences 21 : 77-82                              */
    /******************************************************************************/-->
  		<modified sequence="C-AA/GTT">
  			<enthalpy>20400.0</enthalpy>
  			<entropy>57.0</entropy>
  		</modified>
  		<modified sequence="CAA/G-XT">
  			<enthalpy>40300.0</enthalpy>
  			<entropy>114.0</entropy>
  		</modified>
  		<modified sequence="C-AA/G-XT">
  			<enthalpy>25200.0</enthalpy>
  			<entropy>68.0</entropy>
  		</modified> 		
  		<modified sequence="A-AG/TTC">
  			<enthalpy>29600.0.0</enthalpy>
  			<entropy>86.0</entropy>
  		</modified>
  		<modified sequence="AAG/T-XC">
  			<enthalpy>49600.0.0</enthalpy>
  			<entropy>140.7</entropy>
  		</modified>
  		<modified sequence="A-AG/T-XC">
  			<enthalpy>40200.0</enthalpy>
  			<entropy>111.0</entropy>
  		</modified>
  	</origine>
  </modified_nucleotid>
</hybridisation>

<hybridization type="rnarna">
  <modified_nucleotid type="inosine">
    <origine article="Znosco_2007">
    <!--/******************************************************************************/
    /* contains the parameters for RNA/RNA hybridisation with inosine pairs of Brent M Znosko et al.      */
    /* (2005). Biochemistry 46 : 4625-4634                              */
    /******************************************************************************/-->
        <modified sequence="UA/IU">
            <enthalpy>-10080.0</enthalpy>
            <entropy>-33.8</entropy>
	    </modified>
	    <modified sequence="UU/IA">
	        <enthalpy>-11680.0</enthalpy>
            <entropy>-36.3</entropy>
	    </modified>
	    <modified sequence="UG/IC">
	        <enthalpy>-11990.0</enthalpy>
            <entropy>-36.2</entropy>
	    </modified>
	    <modified sequence="UC/IG">
	        <enthalpy>-9810.0</enthalpy>
            <entropy>-27.4</entropy>
	    </modified>
	    <modified sequence="UU/II">
	        <enthalpy>9530.0</enthalpy>
            <entropy>8.8</entropy>
	    </modified>
	    <modified sequence="UI/IU">
	        <enthalpy>8410.0</enthalpy>
            <entropy>19.9</entropy>
	    </modified> 	        
	    <modified sequence="IA/UU">
            <enthalpy>-8220.0</enthalpy>
            <entropy>-27.9</entropy>
	    </modified>
	    <modified sequence="IU/UA">
	        <enthalpy>-15830.0</enthalpy>
            <entropy>-49.4</entropy>
	    </modified>
	    <modified sequence="IG/UC">
	        <enthalpy>-13380.0</enthalpy>
            <entropy>-39.3</entropy>
	    	</modified>
	    <modified sequence="IC/UG">
	        <enthalpy>-11560.0</enthalpy>
            <entropy>-34.0</entropy>
	    </modified>
	    <modified sequence="IU/UI">
	         <enthalpy>17000.0</enthalpy>
             <entropy>43.3</entropy>
        </modified>    
	    
		<terminal type="per_I/U">
    		<enthalpy>-80.0</enthalpy>
        	<entropy>4.0</entropy>
    	</terminal>
    </origine>
  </modified_nucleotid>
</hybridisation>