<?xml version="1.0" encoding="ISO-8859-1"?>
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/*      USA                                                                  */

/*      Marine Dumousseau                                                    */
/*      EMBL-EBI, neurobiology computational group,                          */
/*      Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->
<!--
    /*************************************************************************/ 
    /* Contains the parameters for single mismatches in DNA/RNA duplexes     */
    /* from Watkins et al. (2010). Nucl. Acids Res. 39, 1894-1902.           */ 
    /*************************************************************************/
    -->

    <data type="single_mismatch">
        <mismatch sequence="dAT/rAA">
                <enthalpy>-4300.0</enthalpy>
                <entropy>-17.3</entropy>
        </mismatch>
        <mismatch sequence="dAA/rAU">
                <enthalpy>-1700.0</enthalpy>
                <entropy>-9.1</entropy>
        </mismatch>
        <mismatch sequence="dAC/rAG">
                <enthalpy>-1900.0</enthalpy>
                <entropy>-7.8</entropy>
        </mismatch>
        <mismatch sequence="dAG/rAC">
                <enthalpy>5500.0</enthalpy>
                <entropy>14.8</entropy>
        </mismatch>
        <mismatch sequence="dTA/rAA">
                <enthalpy>3000.0</enthalpy>
                <entropy>5.3</entropy>
        </mismatch>
        <mismatch sequence="dAA/rUA">
                <enthalpy>5600.0</enthalpy>
                <entropy>12.1</entropy>
        </mismatch>
        <mismatch sequence="dCA/rGA">
                <enthalpy>-10500.0</enthalpy>
                <entropy>-34.5</entropy>
        </mismatch>
        <mismatch sequence="dGA/rCA">
                <enthalpy>-600.0</enthalpy>
                <entropy>-2.5</entropy>
        </mismatch>
        <mismatch sequence="dCT/rCA">
                <enthalpy>-8800.0</enthalpy>
                <entropy>-33.7</entropy>
        </mismatch>
        <mismatch sequence="dCA/rCU">
                <enthalpy>-3300.0</enthalpy>
                <entropy>-14.3</entropy>
        </mismatch>
        <mismatch sequence="dCC/rCG">
                <enthalpy>-100.0</enthalpy>
                <entropy>-3.4</entropy>
        </mismatch>
        <mismatch sequence="dCG/rCC">
                <enthalpy>10500.0</enthalpy>
                <entropy>30.5</entropy>
        </mismatch>
        <mismatch sequence="dTC/rAC">
                <enthalpy>-300.0</enthalpy>
                <entropy>-6.4</entropy>
        </mismatch>
        <mismatch sequence="dAC/rUC">
                <enthalpy>800.0</enthalpy>
                <entropy>-3.5</entropy>
        </mismatch>
        <mismatch sequence="dCC/rGC">
                <enthalpy>-11500.0</enthalpy>
                <entropy>-38.6</entropy>
        </mismatch>
        <mismatch sequence="dGC/rCC">
                <enthalpy>9300.0</enthalpy>
                <entropy>27.6</entropy>
        </mismatch>
        <mismatch sequence="dGT/rGA">
                <enthalpy>-3300.0</enthalpy>
                <entropy>-11.6</entropy>
        </mismatch>
        <mismatch sequence="dGA/rGU">
                <enthalpy>-5800.0</enthalpy>
                <entropy>-20.1</entropy>
        </mismatch>
        <mismatch sequence="dGC/rGG">
                <enthalpy>-8000.0</enthalpy>
                <entropy>-23.9</entropy>
        </mismatch>
        <mismatch sequence="dGG/rGC">
                <enthalpy>-8900.0</enthalpy>
                <entropy>-29.1</entropy>
        </mismatch>
        <mismatch sequence="dTG/rAG">
                <enthalpy>1100.0</enthalpy>
                <entropy>1.9</entropy>
        </mismatch>
        <mismatch sequence="dAG/rUG">
                <enthalpy>-3700.0</enthalpy>
                <entropy>-15.1</entropy>
        </mismatch>
        <mismatch sequence="dCG/rGG">
                <enthalpy>-16500.0</enthalpy>
                <entropy>-52.1</entropy>
        </mismatch>
        <mismatch sequence="dGG/rCG">
                <enthalpy>-7000.0</enthalpy>
                <entropy>-19.9</entropy>
        </mismatch>
        <mismatch sequence="dTT/rUA">
                <enthalpy>600.0</enthalpy>
                <entropy>-0.1</entropy>
        </mismatch>
        <mismatch sequence="dTA/rUU">
                <enthalpy>-2200.0</enthalpy>
                <entropy>-10.5</entropy>
        </mismatch>
        <mismatch sequence="dTC/rUG">
                <enthalpy>-11600.0</enthalpy>
                <entropy>-38.0</entropy>
        </mismatch>
        <mismatch sequence="dTG/rUC">
                <enthalpy>-400.0</enthalpy>
                <entropy>-2.9</entropy>
        </mismatch>
        <mismatch sequence="dTT/rAU">
                <enthalpy>-3300.0</enthalpy>
                <entropy>-14.5</entropy>
        </mismatch>
        <mismatch sequence="dAT/rUU">
                <enthalpy>3000.0</enthalpy>
                <entropy>6.4</entropy>
        </mismatch>
        <mismatch sequence="dCT/rGU">
                <enthalpy>-13400.0</enthalpy>
                <entropy>-43.7</entropy>
        </mismatch>
        <mismatch sequence="dGT/rCU">
                <enthalpy>100.0</enthalpy>
                <entropy>0.4</entropy>
        </mismatch>
    </data>
