<?xml version="1.0" encoding="ISO-8859-1"?>
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/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
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/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

 <!--/******************************************************************************/
    /* contains the parameters for DNA/DNA hybridisation of Breslauer et al.      */
    /* (1986). Proc Natl Acad Sci USA 83 : 3746-3750 
    /******************************************************************************/-->
    
    <data type="crick">
    	<neighbor sequence="AA/TT">
           <enthalpy>-9100.0</enthalpy>
           <entropy>-24.0</entropy>
	    </neighbor>
	    <neighbor sequence="AC/TG">
	         <enthalpy>-6500.0</enthalpy>
             <entropy>-17.3</entropy>
	    </neighbor>
	    <neighbor sequence="AG/TC">
	        <enthalpy>-7800.0</enthalpy>
            <entropy>-20.8</entropy>
	    </neighbor>
	    <neighbor sequence="AT/TA">
	        <enthalpy>-8600.0</enthalpy>
            <entropy>-23.9</entropy>
	    </neighbor>    
        <neighbor sequence="CA/GT">
	        <enthalpy>-5800.0</enthalpy>
            <entropy>-12.9</entropy>
	    </neighbor>
	    <neighbor sequence="CC/GG">
	        <enthalpy>-11000.0</enthalpy>
            <entropy>-26.6</entropy>
	    </neighbor>
	    <neighbor sequence="CG/GC">
	        <enthalpy>-11900.0</enthalpy>
            <entropy>-27.8</entropy>
	    </neighbor>           
        <neighbor sequence="GA/CT">
	        <enthalpy>-5600.0</enthalpy>
            <entropy>-13.5</entropy>
	    </neighbor> 
	    <neighbor sequence="GC/CG">
	        <enthalpy>-11100.0</enthalpy>
            <entropy>-26.7</entropy>
	    </neighbor>                    
        <neighbor sequence="TA/AT">
	        <enthalpy>-6000.0</enthalpy>
            <entropy>-16.9</entropy>
	    </neighbor> 

	    <initiation type="one_GC_Pair">
            <enthalpy>0.0</enthalpy>
            <entropy>-16.8</entropy>
        </initiation>  
        <initiation type="all_AT_pairs">
            <enthalpy>0.0</enthalpy>
            <entropy>-20.1</entropy>
        </initiation> 

        <symmetry>
            <enthalpy>0.0</enthalpy>
            <entropy>-1.3</entropy>
        </symmetry>
      </data> 