<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
/*       it under the terms of the GNU General Public License as published by */
/*       the Free Software Foundation; either version 2 of the License, or    */
/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
/*       MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU    */
/*       General Public License for more details.                             */

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/*       along with this program; if not, write to the Free Software          */
/*       Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307 */
/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->
<!--/******************************************************************************/
    /* contains the parameters for DNA/DNA inosine pairs of Santalucia et al.      */
    /* (2005). Nucleic acids research 33 : 6258-6267                              */
    /******************************************************************************/-->
        
       <data type="modified_nucleotides">
        <modified sequence="AA/IT">
            <enthalpy>-3400.0</enthalpy>
            <entropy>-11.2</entropy>
	    </modified>
	    <modified sequence="AC/IG">
	        <enthalpy>-7800.0</enthalpy>
            <entropy>-21.1</entropy>
	    </modified>
	    <modified sequence="AG/IC">
	        <enthalpy>2600.0</enthalpy>
            <entropy>8.9</entropy>
	    </modified>
	    <modified sequence="AT/IA">
	        <enthalpy>-8300.0</enthalpy>
            <entropy>-25.0</entropy>
	    </modified>
	    <modified sequence="AI/IA">
            <enthalpy>-9500.0</enthalpy>
            <entropy>-29.1</entropy>
       	</modified>           
        <modified sequence="CA/IT">
            <enthalpy>-5900.0</enthalpy>
            <entropy>-17.4</entropy>
	    </modified>
	    <modified sequence="CC/IG">
	        <enthalpy>-6800.0</enthalpy>
            <entropy>-19.1</entropy>
	    </modified>
	    <modified sequence="CG/IC">
	        <enthalpy>-5400.0</enthalpy>
            <entropy>-13.7</entropy>
	    </modified>
	    <modified sequence="CT/IA">
	        <enthalpy>-8900.0</enthalpy>
            <entropy>-25.5</entropy>
	    </modified>
	    <modified sequence="CI/IC">
	         <enthalpy>-1800.0</enthalpy>
             <entropy>-6.4</entropy> 
        </modified>	
        <modified sequence="GA/IT">
            <enthalpy>-1900.0</enthalpy>
            <entropy>-8.5</entropy>
	    </modified>
	    <modified sequence="GC/IG">
	         <enthalpy>-1100.0</enthalpy>
             <entropy>-3.2</entropy>
	    </modified>
	    <modified sequence="GG/IC">
	        <enthalpy>7100.0</enthalpy>
            <entropy>21.3</entropy>
	    </modified>
	    <modified sequence="GT/IA">
	        <enthalpy>-4900.0</enthalpy>
            <entropy>-15.8</entropy>
	    </modified>
	    <modified sequence="GI/IG">
	       	<enthalpy>-4200.0</enthalpy>
            <entropy>-39.8</entropy>  
        </modified>
        <modified sequence="TA/IT">
            <enthalpy>-6500.0</enthalpy>
            <entropy>-22.0</entropy>
	    </modified>
	    <modified sequence="TC/IG">
	        <enthalpy>-3500.0</enthalpy>
            <entropy>-10.6</entropy>
	    </modified>
	    <modified sequence="TG/IC">
	        <enthalpy>-1000.0</enthalpy>
            <entropy>-2.4</entropy>
	    </modified>
	    <modified sequence="TT/IA">
	        <enthalpy>490.0</enthalpy>
            <entropy>-0.7</entropy>
	    </modified>
	    <modified sequence="TI/IT">
	        <enthalpy>-14700.0</enthalpy>
            <entropy>-49.4</entropy>
		</modified>	        
	    <modified sequence="IA/AT">
            <enthalpy>-1300.0</enthalpy>
            <entropy>-4.6</entropy>
	    </modified>
	    <modified sequence="IC/AG">
	        <enthalpy>-7600.0</enthalpy>
            <entropy>-20.2</entropy>
	    </modified>
	    <modified sequence="IG/AC">
	        <enthalpy>-7000.0</enthalpy>
            <entropy>-20.0</entropy>
	    </modified>
	    <modified sequence="IT/AA">
	        <enthalpy>-700.0</enthalpy>
            <entropy>-2.6</entropy>
	    </modified>
	    <modified sequence="IA/AI">
	        <enthalpy>-13900.0</enthalpy>
            <entropy>-40.5</entropy>
        </modified>            
        <modified sequence="IA/CT">
            <enthalpy>-4900.0</enthalpy>
            <entropy>-13.9</entropy>
	    </modified>
	    <modified sequence="IC/CG">
	         <enthalpy>-5000.0</enthalpy>
             <entropy>-12.6</entropy>
	    </modified>
	    <modified sequence="IG/CC">
	        <enthalpy>-8300.0</enthalpy>
            <entropy>-23.8</entropy>
	    </modified>
	    <modified sequence="IT/CA">
	        <enthalpy>-8800.0</enthalpy>
            <entropy>-25.4</entropy>
	    </modified>
	    <modified sequence="IC/CI">
	        <enthalpy>-12100.0</enthalpy>
            <entropy>-36.3</entropy>
        </modified>	
        <modified sequence="IA/GT">
            <enthalpy>1000.0</enthalpy>
            <entropy>1.0</entropy>
	    </modified>
	    <modified sequence="IC/GG">
	        <enthalpy>-7600.0</enthalpy>
            <entropy>-22.0</entropy>
	    </modified>
	    <modified sequence="IG/GC">
	        <enthalpy>5800.0</enthalpy>
            <entropy>16.9</entropy>
	    </modified>
	    <modified sequence="IT/GA">
	        <enthalpy>100.0</enthalpy>
            <entropy>-1.8</entropy>
	    </modified>
	    <modified sequence="IG/GI">
	        <enthalpy>3200.0</enthalpy>
            <entropy>6.1</entropy>
        </modified>        
        <modified sequence="IA/TT">
            <enthalpy>-800.0</enthalpy>
            <entropy>-4.3</entropy>
	    </modified>
	    <modified sequence="IC/TG">
	        <enthalpy>-4300.0</enthalpy>
            <entropy>-12.1</entropy>
	    </modified>
	    <modified sequence="IG/TC">
	        <enthalpy>100.0</enthalpy>
            <entropy>-1.0</entropy>
	    </modified>
	    <modified sequence="IT/TA">
	        <enthalpy>-5600.0</enthalpy>
            <entropy>-18.7</entropy>
	    </modified>
	    <modified sequence="IT/TI">
	        <enthalpy>-7600.0</enthalpy>
            <entropy>-31.1</entropy>
	    </modified>
	    <modified sequence="IC/IG">
	         <enthalpy>-500.0</enthalpy>
             <entropy>-1.3</entropy>
	    </modified>
	    <modified sequence="IG/IC">
	        <enthalpy>1300.0</enthalpy>
            <entropy>3.0</entropy>
	    </modified>
	    <modified sequence="IT/IA">
	        <enthalpy>-3300.0</enthalpy>
            <entropy>-11.9</entropy>
	    </modified>
	    <modified sequence="IA/IT">
	        <enthalpy>100.0</enthalpy>
            <entropy>-2.3</entropy>
        </modified>
      </data>
