<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
/*       it under the terms of the GNU General Public License as published by */
/*       the Free Software Foundation; either version 2 of the License, or    */
/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
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/*       General Public License for more details.                             */

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/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<!--/******************************************************************************/
    /* contains the parameters for DNA/DNA consecutive locked acid nucleic of
    /* - Owczarzy et al.(2011). Biochemistry 2011, 50, 9352-9367  */
    /******************************************************************************/-->

<data type="tandem_modified_nucleotides">
    <modified   sequence="ALAL/TT">
        <enthalpy>-9991.0</enthalpy>
        <entropy>-27.175</entropy>
    </modified>
    <modified   sequence="ALCL/TG">
        <enthalpy>-11389.0</enthalpy>
        <entropy>-28.963</entropy>
    </modified>
    <modified   sequence="ALGL/TC">
        <enthalpy>-12793.0</enthalpy>
        <entropy>-31.607</entropy>
    </modified>
    <modified   sequence="ALTL/TA">
        <enthalpy>-14703.0</enthalpy>
        <entropy>-40.750</entropy>
    </modified>
    <modified   sequence="CLAL/GT">
        <enthalpy>-14177.0</enthalpy>
        <entropy>-35.498</entropy>
    </modified>
    <modified   sequence="CLCL/GG">
        <enthalpy>-15399.0</enthalpy>
        <entropy>-36.375</entropy>
    </modified>
    <modified   sequence="CLGL/GC">
        <enthalpy>-14558.0</enthalpy>
        <entropy>-35.239</entropy>
    </modified>
    <modified   sequence="CLTL/GA">
        <enthalpy>-15737.0</enthalpy>
        <entropy>-41.218</entropy>
    </modified>
    <modified   sequence="GLAL/CT">
        <enthalpy>-13959.0</enthalpy>
        <entropy>-35.097</entropy>
    </modified>
    <modified   sequence="GLCL/CG">
        <enthalpy>-16109.0</enthalpy>
        <entropy>-40.738</entropy>
    </modified>
    <modified   sequence="GLGL/CC">
        <enthalpy>-13022.0</enthalpy>
        <entropy>-29.673</entropy>
    </modified>
    <modified   sequence="GLTL/CA">
        <enthalpy>-17361.0</enthalpy>
        <entropy>-45.858</entropy>
    </modified>
    <modified   sequence="TLAL/AT">
        <enthalpy>-10318.0</enthalpy>
        <entropy>-26.108</entropy>
    </modified>
    <modified   sequence="TLCL/AG">
        <enthalpy>-9166.0</enthalpy>
        <entropy>-21.735</entropy>
    </modified>
    <modified   sequence="TLGL/AC">
        <enthalpy>-10046.0</enthalpy>
        <entropy>-22.591</entropy>
    </modified>
    <modified   sequence="TLTL/AA">
        <enthalpy>-10419.0</enthalpy>
        <entropy>-27.683</entropy>
    </modified>
</data>
