<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
/*       it under the terms of the GNU General Public License as published by */
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/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
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/*       General Public License for more details.                             */

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/*       Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307 */
/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<hybridization type="dnadna">
	<mismatches type="single">
    	<origine article="Allawi_Santalucia_Peyret_1997_1998_1999">
    	<!--/******************************************************************************/
    	/* contains the parameters for DNA/DNA mismatcheses of ;
	REF: Allawi and SantaLucia (1997). Biochemistry 36: 10581-10594. 
	REF: Allawi and SantaLucia (1998). Biochemistry 37: 2170-2179.
	REF: Allawi and SantaLucia (1998). Nuc Acids Res 26: 2694-2701. 
	REF: Allawi and SantaLucia (1998). Biochemistry 37: 9435-9444.
	REF: Peyret et al. (1999). Biochemistry 38: 3468-3477
    	/******************************************************************************/-->
			<mismatch sequence="AA/AT">
               	<enthalpy>4700.0</enthalpy>
              	<entropy>12.9</entropy>
	    	</mismatch>
	    	<mismatch sequence="AC/AG">
	       		<enthalpy>-2900.0</enthalpy>
               	<entropy>-9.8</entropy>
	   		</mismatch>
	   		<mismatch sequence="AG/AC">
        		<enthalpy>-900.0</enthalpy>
                <entropy>-4.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="AT/AA">
	       		<enthalpy>1200.0</enthalpy>
               	<entropy>1.7</entropy>
	   		</mismatch>
    	   	<mismatch sequence="AA/CT">
	       		<enthalpy>7600.0</enthalpy>
             	<entropy>20.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="AC/CG">
	       		<enthalpy>-700.0</enthalpy>
               	<entropy>-3.8</entropy>
	   		</mismatch>
	   		<mismatch sequence="AG/CC">
        		<enthalpy>600.0</enthalpy>
                <entropy>-0.6</entropy>
	    	</mismatch>
	    	<mismatch sequence="AT/CA">
	       		<enthalpy>5300.0</enthalpy>
               	<entropy>14.6</entropy>
	   		</mismatch>            
    	   	<mismatch sequence="AA/GT">
	       		<enthalpy>3000.0</enthalpy>
               	<entropy>7.4</entropy>
	   		</mismatch> 
	    	<mismatch sequence="AC/GG">
	       		<enthalpy>500.0</enthalpy>
               	<entropy>3.2</entropy>
	   		</mismatch> 
	    	<mismatch sequence="AG/GC">
	       		<enthalpy>-4000.0</enthalpy>
               	<entropy>-13.2</entropy>
	    	</mismatch> 
	   		<mismatch sequence="AT/GA">
	       		<enthalpy>-700.0</enthalpy>
               	<entropy>-2.3</entropy>
	   		</mismatch>            
        	<mismatch sequence="TA/TT">
	       		<enthalpy>200.0</enthalpy>
               	<entropy>-1.5</entropy>
	    	</mismatch> 
	   		<mismatch sequence="TC/TG">
	       		<enthalpy>-2200.0</enthalpy>
               	<entropy>-8.4</entropy>
	   		</mismatch> 
    		<mismatch sequence="TG/TC">
	       		<enthalpy>-5000.0</enthalpy>
               	<entropy>-15.8</entropy>
	    	</mismatch> 
	   		<mismatch sequence="TT/TA">
	       		<enthalpy>-2700.0</enthalpy>
             	<entropy>-10.8</entropy>
	    	</mismatch>
	    	<mismatch sequence="TA/CT">
	       		<enthalpy>1200.0</enthalpy>
               	<entropy>0.7</entropy>
	    	</mismatch> 
	    	<mismatch sequence="TC/CG">
	       		<enthalpy>2300.0</enthalpy>
               	<entropy>5.4</entropy>
	   		</mismatch> 
	    	<mismatch sequence="TG/CC">
	       		<enthalpy>-800.0</enthalpy>
               	<entropy>-4.5</entropy>
	   		</mismatch> 
	   		<mismatch sequence="TT/CA">
        		<enthalpy>700.0</enthalpy>
               	<entropy>0.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="TA/GT">
	       		<enthalpy>-100.0</enthalpy>
               	<entropy>-1.7</entropy>
	    	</mismatch> 
	    	<mismatch sequence="TC/GG">
	       		<enthalpy>3300.0</enthalpy>
               	<entropy>10.4</entropy>
	    	</mismatch> 
	   		<mismatch sequence="TG/GC">
	       		<enthalpy>-4100.0</enthalpy>
               	<entropy>-11.7</entropy>
	   		</mismatch> 
    		<mismatch sequence="TT/GA">
	        	<enthalpy>1000.0</enthalpy>
              	<entropy>0.9</entropy>
	    	</mismatch>
	   		<mismatch sequence="CA/CT">
	       		<enthalpy>6100.0</enthalpy>
               	<entropy>16.4</entropy>
	    	</mismatch> 
	    	<mismatch sequence="CC/CG">
	       		<enthalpy>3600.0</enthalpy>
               	<entropy>8.9</entropy>
	   		</mismatch> 
	   		<mismatch sequence="CG/CC">
        		<enthalpy>-1500.0</enthalpy>
                <entropy>-7.2</entropy>
	    	</mismatch> 
	    	<mismatch sequence="CT/CA">
	       		<enthalpy>0.0</enthalpy>
              	<entropy>-4.4</entropy>
	    	</mismatch>
	    	<mismatch sequence="CA/AT">
	        	<enthalpy>3400.0</enthalpy>
               	<entropy>8.0</entropy>
	    	</mismatch> 
	    	<mismatch sequence="CC/AG">
	       		<enthalpy>5200.0</enthalpy>
               	<entropy>14.2</entropy>
	   		</mismatch> 
	    	<mismatch sequence="CG/AC">
	       		<enthalpy>1900.0</enthalpy>
               	<entropy>3.7</entropy>
	    	</mismatch> 
	   		<mismatch sequence="CT/AA">
	       		<enthalpy>-9100.0</enthalpy>
              	<entropy>-24.0</entropy>
	    	</mismatch>
	    	<mismatch sequence="CA/TT">
	       		<enthalpy>1000.0</enthalpy>
               	<entropy>0.7</entropy>
	    	</mismatch> 
	   		<mismatch sequence="CC/TG">
	       		<enthalpy>5200.0</enthalpy>
               	<entropy>13.5</entropy>
	   		</mismatch> 
	    	<mismatch sequence="CG/TC">
	       		<enthalpy>-1500.0</enthalpy>
               	<entropy>-6.1</entropy>
	   		</mismatch> 
	    	<mismatch sequence="CT/TA">
	       		<enthalpy>-1200.0</enthalpy>
             	<entropy>-6.2</entropy>
	    	</mismatch>
	    	<mismatch sequence="GA/GT">
	        	<enthalpy>1600.0</enthalpy>
                <entropy>3.6</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GC/GG">
	       		<enthalpy>-6000.0</enthalpy>
               	<entropy>-15.8</entropy>
	    	</mismatch> 
	   		<mismatch sequence="GG/GC">
	       		<enthalpy>-4900.0</enthalpy>
               	<entropy>-15.3</entropy>
	   		</mismatch> 
	    	<mismatch sequence="GT/GA">
	       		<enthalpy>-3100.0</enthalpy>
             	<entropy>-9.5</entropy>
	    	</mismatch>
	    	<mismatch sequence="GA/AT">
	       		<enthalpy>700.0</enthalpy>
               	<entropy>0.7</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GC/AG">
	       		<enthalpy>-600.0</enthalpy>
               	<entropy>-1.0</entropy>
	    	</mismatch> 
	   		<mismatch sequence="GG/AC">
	       		<enthalpy>-700.0</enthalpy>
               	<entropy>-2.3</entropy>
	    	</mismatch> 
	   		<mismatch sequence="GT/AA">
	       		<enthalpy>-600.0</enthalpy>
             	<entropy>-2.3</entropy>
	    	</mismatch>
	    	<mismatch sequence="GA/TT">
	       		<enthalpy>-1300.0</enthalpy>
                <entropy>-5.3</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GC/TG">
	       		<enthalpy>-4400.0</enthalpy>
               	<entropy>-12.3</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GG/TC">
	       		<enthalpy>-2800.0</enthalpy>
               	<entropy>-8.0</entropy>
	   		</mismatch> 
	   		<mismatch sequence="GT/TA">
        		<enthalpy>-2500.0</enthalpy>
               	<entropy>-8.3</entropy>
	    	</mismatch>
    	</origine>
    </mismatches>
    
    <mismatches type="tandem">
    	<origine article="Allawi_Santalucia_Peyret_1997_1998_1999">
    	<!--/******************************************************************************/
    	/* contains the parameters for DNA/DNA mismatches of ;
	REF: Allawi and SantaLucia (1997). Biochemistry 36: 10581-10594. 
	REF: Allawi and SantaLucia (1998). Biochemistry 37: 2170-2179.
	REF: Allawi and SantaLucia (1998). Nuc Acids Res 26: 2694-2701. 
	REF: Allawi and SantaLucia (1998). Biochemistry 37: 9435-9444.
	REF: Peyret et al. (1999). Biochemistry 38: 3468-3477
    	/******************************************************************************/-->
    		<mismatch sequence="GT/TT">
	        	<enthalpy>5800.0</enthalpy>
                <entropy>16.3</entropy>
	    	</mismatch> 
	    	<mismatch sequence="GT/TG">
	       		<enthalpy>4100.0</enthalpy>
               	<entropy>9.5</entropy>
	    	</mismatch> 
	    	<mismatch sequence="TA/TG">
	        	<enthalpy>-100.0</enthalpy>
               	<entropy>-1.7</entropy>
	    	</mismatch>
	        <mismatch sequence="TG/GT">
	        	<enthalpy>-1400.0</enthalpy>
               	<entropy>-6.2</entropy>
	    	</mismatch>
    	</origine>
     </mismatches>
     
     <mismatches type="long">
     	<origine article="Santalucia_2004">
 <!--/******************************************************************************/
    contains the parameters for DNA/DNA mismatch loops of Santalucia et al       */
/* (2004). Annu. Rev. Biophys. Biomol. Struct 33 : 415-440                                            */                                                    
/******************************************************************************/-->
  			<mismatch size="3">
  				<entropy>-10.3</entropy>
  			</mismatch>
  			<mismatch size="4">
  				<entropy>-11.6</entropy>
  			</mismatch>
  			<mismatch size="5">
  				<entropy>-12.9</entropy>
  			</mismatch>
  			<mismatch size="6">
  				<entropy>-14.2</entropy>
  			</mismatch>
  			<mismatch size="7">
  				<entropy>-14.8</entropy>
  			</mismatch>
  			<mismatch size="8">
  				<entropy>-15.5</entropy>
  			</mismatch>
  			<mismatch size="9">
  				<entropy>-15.8</entropy>
  			</mismatch>
  			<mismatch size="10">
  				<entropy>-15.8</entropy>
  			</mismatch>
 			<mismatch size="12">
  				<entropy>-16.7</entropy>
  			</mismatch>
 			<mismatch size="14">
  				<entropy>-17.4</entropy>
  			</mismatch>
 			<mismatch size="16">
  				<entropy>-18.1</entropy>
  			</mismatch>
 			<mismatch size="18">
  				<entropy>-18.7</entropy>
  			</mismatch>
 			<mismatch size="20">
  				<entropy>-19.0</entropy>
  			</mismatch>
 			<mismatch size="25">
  				<entropy>-20.3</entropy>
  			</mismatch>
 			<mismatch size="30">
  				<entropy>-21.3</entropy>
  			</mismatch>
  		</origine>
     </mismatches>
   </hybridization>
   
   <hybridization type="rnarna">
   	<mismatches type="single">
   		<origine article="Znosko_2007">
   		   	<!--/******************************************************************************/
    	/* contains the parameters for RNA/RNA mismatches of ;
	REF: Brent M Znosko et al (2007). Biochemistry 46: 13425-13436. 
    	/******************************************************************************/-->
   			<parameters pair="A/G">
	        	<enthalpy>-6900.0</enthalpy>
                <entropy>-21.0</entropy>
   			</parameters>	
   			<parameters pair="G/G">
	        	<enthalpy>-18200.0</enthalpy>
                <entropy>-51.8</entropy>
   			</parameters>			
   			<parameters pair="U/U">
	        	<enthalpy>-12600.0</enthalpy>
                <entropy>-39.6</entropy>
   			</parameters>
   			
   			<mismatch sequence="YRR/RRY">
	        	<enthalpy>200.0</enthalpy>
                <entropy>-1.4</entropy>
   			</mismatch>
  			<mismatch sequence="RYY/YYR">
	        	<enthalpy>-5500.0</enthalpy>
                <entropy>-16.2S</entropy>
   			</mismatch>
  			<mismatch sequence="YYR/RYY">
	        	<enthalpy>2200.0</enthalpy>
                <entropy>5.7</entropy>
   			</mismatch>
  			<mismatch sequence="YRY/RYR">
	        	<enthalpy>-7700.0</enthalpy>
                <entropy>-23.4</entropy>
   			</mismatch>
  			<mismatch sequence="RRY/YYR">
	        	<enthalpy>-19500.0</enthalpy>
                <entropy>-59.7</entropy>
   			</mismatch>
   			
  			<closure type="per_AU">
	        	<enthalpy>-1800.0</enthalpy>
                <entropy>-9.8</entropy>
   			</closure>
   			<closure type="per_GU">
	        	<enthalpy>-1800.0</enthalpy>
                <entropy>-9.8</entropy>
   			</closure>	
   		</origine>
   		
   		<origine article="Znosko_2008">
   		   	<!--/******************************************************************************/
    	/* contains the parameters for RNA/RNA mismatcheses of ;
	REF: Brent M Znosko et al (2008). Biochemistry 47: 10178-10187. 
    	/******************************************************************************/-->
   			<parameters pair="A/G">
	        	<enthalpy>-800.0</enthalpy>
                <entropy>-10.4</entropy>
   			</parameters>	
   			<parameters pair="G/G">
	        	<enthalpy>-17900.0</enthalpy>
                <entropy>-52.2</entropy>
   			</parameters>			
   			<parameters pair="U/U">
	        	<enthalpy>-14900.0</enthalpy>
                <entropy>-45.7</entropy>
   			</parameters>
   			
   			<mismatch sequence="YRR/RRY">
	        	<enthalpy>800.0</enthalpy>
                <entropy>6.2</entropy>
   			</mismatch>
  			<mismatch sequence="RYY/YYR">
	        	<enthalpy>-300.0</enthalpy>
                <entropy>-1.2</entropy>
   			</mismatch>
  			<mismatch sequence="YYR/RYY">
	        	<enthalpy>2600.0</enthalpy>
                <entropy>6.5</entropy>
   			</mismatch>
  			<mismatch sequence="YRY/RYR">
	        	<enthalpy>-7000.0</enthalpy>
                <entropy>-20.3</entropy>
   			</mismatch>
  			<mismatch sequence="RRY/YYR">
	        	<enthalpy>-17300.0</enthalpy>
                <entropy>-54.5</entropy>
   			</mismatch>
   			
  			<closure type="per_A/U">
	        	<enthalpy>-4000.0</enthalpy>
                <entropy>-15.0</entropy>
   			</closure>	
  			<closure type="per_G/U">
	        	<enthalpy>-4000.0</enthalpy>
                <entropy>-19.3</entropy>
   			</closure>	
   		</origine>
   	</mismatches>
   	
   	<mismatches type="woddle">
   		<origine article="Turner_1999">
    <!--/******************************************************************************/
    contains the parameters for RNA/RNA hybridisation with GU base pairs of Turner et al (1999)      */
/* J.Mol.Biol.  288: 911_940                                                                         
/******************************************************************************/-->
        <mismatch sequence="AG/UU">
	        <enthalpy>-3200.0</enthalpy>
            <entropy>-8.6</entropy>
	   	</mismatch> 
	   	<mismatch sequence="AU/UG">
	        <enthalpy>-8810.0</enthalpy>
            <entropy>-24.0</entropy>               
        </mismatch>
        <mismatch sequence="CG/GU">
	        <enthalpy>-5610.0</enthalpy>
            <entropy>-13.5</entropy>
	   	</mismatch> 
	   	<mismatch sequence="CU/GG">
	        <enthalpy>-12110.0</enthalpy>
            <entropy>-32.2</entropy>           
        </mismatch>
        <mismatch sequence="GG/CU">
	        <enthalpy>-8330.0</enthalpy>
            <entropy>-21.9</entropy>
	   	</mismatch> 
	   	<mismatch sequence="GU/CG">
	       	<enthalpy>-12590.0</enthalpy>
            <entropy>-32.5</entropy>              
        </mismatch>
        <mismatch sequence="UG/AU">
	       	<enthalpy>-6990.0</enthalpy>
            <entropy>-19.3 </entropy>
	   	</mismatch>
	   	<mismatch sequence="UU/AG">
	       	<enthalpy>-12830.0</enthalpy>
            <entropy>-37.3 </entropy>             
        </mismatch> 
        <mismatch sequence="GG/UU">
	       	<enthalpy>-13470.0</enthalpy>
            <entropy>-44.9</entropy>
	   	</mismatch>
	   	<mismatch sequence="GU/UG" closing="G/C">
	       	<enthalpy>-30800.0</enthalpy>
            <entropy>-86.0</entropy>
	   	</mismatch>
	   	<mismatch sequence="GU/UG" closing="not_G/C">                                                                                                                                                                                                                                                                                                                                        "">
        	<enthalpy>-14590.0</enthalpy>
			<entropy>-51.2</entropy>              
        </mismatch>
        <mismatch sequence="UG/GU">
	        <enthalpy>-9260.0</enthalpy>
            <entropy>-30.8</entropy>           
        </mismatch> 
        
        <terminal type="per_G/U">
            <enthalpy>3720.0</enthalpy>
            <entropy>10.5</entropy>
        </terminal>  
    </origine>
   	</mismatches>
   	
   	<mismatches type="tandem">
   	  <origine article="Turner_1999_2006">
       <!--/******************************************************************************/
    	/* contains the parameters for RNA/RNA tandem mismatcheses of ;
	REF: Douglas M Turner et al (2006). Nucleic Acids Research 34: 4912-4924.
	REF: Douglas M Turner et al (1999). J.Mol.Biol.  288: 911_940 
    	/******************************************************************************/-->
   		<mismatch sequence="GA/AG" closing="G/C">
   			<enthalpy>-25100.0</enthalpy>
  			<entropy>-72.5</entropy>
   		</mismatch>
   		<mismatch sequence="AG/GA" closing="G/C">
   			<enthalpy>-15600.0</enthalpy>
   			<entropy>-46.1</entropy>
   		</mismatch>
   		<mismatch sequence="UU/UU" closing="G/C">
   			<enthalpy>-14400.0</enthalpy>
   			<entropy>-44.8</entropy>
   		</mismatch>
   		<mismatch sequence="GG/GG" closing="G/C">
   			<enthalpy>-22800.0</enthalpy>
   			<entropy>-76.1</entropy>
   		</mismatch>
  		<mismatch sequence="CA/AC" closing="G/C">
   			<enthalpy>-10300.0</enthalpy>
  			<entropy>-36.4</entropy>
   		</mismatch>
   		<mismatch sequence="CU/UC" closing="G/C">
   			<enthalpy>-20900.0</enthalpy>
   			<entropy>-70.9</entropy>
   		</mismatch>
   		<mismatch sequence="UC/CU" closing="G/C">
   			<enthalpy>-14700.0</enthalpy>
   			<entropy>-50.6</entropy>
  		</mismatch>
   		<mismatch sequence="CC/CC" closing="G/C">
   			<enthalpy>-14700.0</enthalpy>
   			<entropy>-50.6</entropy>
   		</mismatch>
   		<mismatch sequence="AC/CA" closing="G/C">
   			<enthalpy>-8600.0</enthalpy>
   			<entropy>-30.6</entropy>
   		</mismatch>
   		<mismatch sequence="AA/AA" closing="G/C">
   			<enthalpy>-1300.0</enthalpy>
   			<entropy>-9.0</entropy>
   		</mismatch>
  		<mismatch sequence="GA/AG" closing="C/G">
   			<enthalpy>-14600.0</enthalpy>
   			<entropy>-44.8</entropy>
   		</mismatch>
   		<mismatch sequence="AG/GA" closing="C/G">
   			<enthalpy>-12700.0</enthalpy>
   			<entropy>-38.7</entropy>
   		</mismatch>
   		<mismatch sequence="UU/UU" closing="C/G">
  			<enthalpy>-17500.0</enthalpy>
   			<entropy>-55.1</entropy>
   		</mismatch>
   		<mismatch sequence="GG/GG" closing="C/G">
   			<enthalpy>-22800.0</enthalpy>
   			<entropy>-76.1</entropy>
   		</mismatch>
   		<mismatch sequence="CA/AC" closing="C/G">
   			<enthalpy>-10800.0</enthalpy>
   			<entropy>-38.4</entropy>
 		</mismatch>
   		<mismatch sequence="CU/UC" closing="C/G">
   			<enthalpy>-600.0</enthalpy>
   			<entropy>-6.4</entropy>
   		</mismatch>
   		<mismatch sequence="UC/CU" closing="C/G">
   			<enthalpy>-2800.0</enthalpy>
   			<entropy>-13.5</entropy>
   		</mismatch>
   		<mismatch sequence="CC/CC" closing="C/G">
   			<enthalpy>-1800.0</enthalpy>
   			<entropy>-11.3</entropy>
   		</mismatch>
   		<mismatch sequence="AC/CA" closing="C/G">
   			<enthalpy>-1700.0</enthalpy>
   			<entropy>-11.9</entropy>
   		</mismatch>
   		<mismatch sequence="AA/AA" closing="C/G">
   			<enthalpy>-4600.0</enthalpy>
   				<entropy>-19.0</entropy>
   		</mismatch>
  		<mismatch sequence="GA/AG" closing="U/A">
  			<enthalpy>-13400.0</enthalpy>
   			<entropy>-45.5</entropy>
   		</mismatch>
   		<mismatch sequence="AG/GA" closing="U/A">
   			<enthalpy>-19400.0</enthalpy>
   			<entropy>-64.8</entropy>
   		</mismatch>
   		<mismatch sequence="UU/UU" closing="U/A">
 			<enthalpy>-6700.0</enthalpy>
   			<entropy>-25.1</entropy>
   		</mismatch>
   		<mismatch sequence="GG/GG" closing="U/A"> 
   			<enthalpy>2700.0</enthalpy>
   			<entropy>3.9</entropy>
   		</mismatch>
   		<mismatch sequence="CA/AC" closing="U/A">
   			<enthalpy>9100.0</enthalpy>
   			<entropy>23.2</entropy>
   		</mismatch>
   		<mismatch sequence="CU/UC" closing="U/A">
   			<enthalpy>3300.0</enthalpy>
   			<entropy>3.5</entropy>
   		</mismatch>
   		<mismatch sequence="UC/CU" closing="U/A">
   			<enthalpy>9500.0</enthalpy>
  			<entropy>21.6</entropy>
   		</mismatch>
   		<mismatch sequence="CC/CC" closing="U/A">
   			<enthalpy>12100.0</enthalpy>
   			<entropy>30.0</entropy>
   		</mismatch>
   		<mismatch sequence="AC/CA" closing="U/A">
   			<enthalpy>12100.0</enthalpy>
   			<entropy>30.1</entropy>
   		</mismatch>
  		<mismatch sequence="AA/AA" closing="U/A">
  			<enthalpy>14700.0</enthalpy>
   			<entropy>38.4</entropy>
   		</mismatch>
  		<mismatch sequence="GA/AG" closing="A/U">
   			<enthalpy>-14400.0</enthalpy>
   			<entropy>-47.4</entropy>
   		</mismatch>
   		<mismatch sequence="AG/GA" closing="A/U">
   			<enthalpy>-10800.0</enthalpy>
   			<entropy>-35.8</entropy>
   		</mismatch>
   		<mismatch sequence="UU/UU" closing="A/U">
   			<enthalpy>-12200.0</enthalpy>
   			<entropy>-41.3</entropy>
   		</mismatch>
   		<mismatch sequence="GG/GG" closing="A/U">
   			<enthalpy>-1000.0</enthalpy>
   			<entropy>-7.7</entropy>
   		</mismatch>
   		<mismatch sequence="CA/AC" closing="A/U">
   			<enthalpy>7200.0</enthalpy>
   			<entropy>15.8</entropy>
   		</mismatch>
   		<mismatch sequence="CU/UC" closing="A/U">
   			<enthalpy>7400.0</enthalpy>
   			<entropy>-16.8</entropy>
   		</mismatch>
   		<mismatch sequence="UC/CU" closing="A/U">
   			<enthalpy>7400.0</enthalpy>
   			<entropy>-16.8</entropy>
   		</mismatch>
   		<mismatch sequence="CC/CC" closing="A/U">
   			<enthalpy>7400.0</enthalpy>
   			<entropy>-16.8</entropy>
   		</mismatch>
   		<mismatch sequence="AC/CA" closing="A/U">
   			<enthalpy>7500.0</enthalpy>
   			<entropy>16.1</entropy>
   		</mismatch>
   		<mismatch sequence="AA/AA" closing="A/U">
   			<enthalpy>13400.0</enthalpy>
   			<entropy>34.2</entropy>
   		</mismatch>
  		<mismatch sequence="GA/AG" closing="U/G">
   			<enthalpy>-15300.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="AG/GA" closing="U/G">
   			<enthalpy>-18700.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="UU/UU" closing="U/G">
 			<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="GG/GG" closing="U/G">
   			<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="CA/AC" closing="U/G">
   			<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="CU/UC" closing="U/G">
   				<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="UC/CU" closing="U/G">
  			<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="CC/CC" closing="U/G">
   			<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="AC/CA" closing="U/G">
   			<enthalpy>-8500.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="AA/AA" closing="U/G">
   			<enthalpy>1700.0</enthalpy>
   		</mismatch>
  		<mismatch sequence="GA/AG"  closing="G/U">
   			<enthalpy>-19900.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="AG/GA" closing="U/G">
   			<enthalpy>-16100.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="UU/UU" closing="U/G">
  			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="GG/GG" closing="U/G">
  			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="CA/AC" closing="U/G">
   			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="CU/UC" closing="U/G">
   			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="UC/CU" closing="U/G">
   			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="CC/CC" closing="U/G">
   			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="AC/CA" closing="U/G">
   			<enthalpy>-19600.0</enthalpy>
   		</mismatch>
   		<mismatch sequence="AA/AA" closing="U/G">
   			<enthalpy>-23200.0</enthalpy>
   		</mismatch>
   	  </origine>
   	</mismatches>
   	
   	<mismatches type="long">
   		<origine article="Turner_1999_2006">
       <!--/******************************************************************************/
    	/* contains the parameters for RNA/RNA mismatch loop of ;
	REF: Douglas M Turner et al (2006). Nucleic Acids Research 34: 4912-4924. 
    REF: Douglas M Turner et al (1999). J.Mol.Biol.  288: 911_940 
    	/******************************************************************************/-->
 			<mismatch size="2" type="initiation">
 				<enthalpy>-10500.0<enthalpy>
 				<entropy>-35.46</entropy>
 			</mismatch>
 			<mismatch size="3" type="initiation">
 				<enthalpy>300.0<enthalpy>
 				<entropy>-4.51</entropy>
 			</mismatch>
 			<mismatch size="4" type="initiation">
 				<enthalpy>-7200.0<enthalpy>
				<entropy>-26.73</entropy>
 			</mismatch>
 			<mismatch size="5" type="initiation">
 				<enthalpy>-6800.0<enthalpy>
 				<entropy>-28.37</entropy>
 			</mismatch>
 			<mismatch size="6" type="initiation">
 				<enthalpy>-1300.0<enthalpy>
 				<entropy>-10.64</entropy>
 			</mismatch>
 			<mismatch size=">6" type="initiation">
 				<enthalpy>-1300.0<enthalpy>
 				<entropy formule="-3.3 - 1.08ln(n/6)">-3.3</entropy>
 			</mismatch>
 			
 			<penalty type="per_AU_GU_closure">
 				<enthalpy>5000.0<enthalpy>
 				<entropy>13.86</entropy>
 			</penalty>
 			
 			<penalty type="G/G_adjacent_AA_or_nonCanonicalPyrimidine">
 				<enthalpy>12500.0</enthalpy>
 				<entropy>0.0</entropy>
 			</penalty>
 			
 			<penalty type="AG_GA_UU_adjacent_UU_CU_CC_AA">
 				<enthalpy>2400.0</enthalpy>
 				<entropy>0.0</entropy>
 			</penalty>
 			
 			<asymmetry>
 				<enthalpy>3200.0<enthalpy>
 				<entropy>8.38</entropy>
 			</asymmetry>
 			
 			<mismatch sequence="RA/YG" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RA/YG" loop="1xn_n>3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RA/YG" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RA/YG" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-3400.0</enthalpy>
 				<entropy>-8.38</entropy>
 			</mismatch>

 			<mismatch sequence="YA/RG loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.83</entropy>
 			</mismatch>
 			<mismatch sequence="YA/RG loop="1xn_n>3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="YA/RG loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-5700.0</enthalpy>
 				<entropy>-4.09.0</entropy>
 			</mismatch>
 			<mismatch sequence="YA/RG loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-3400</enthalpy>
 				<entropy>-8.38</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.83</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="1xn_n>3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-10900.0</enthalpy>
 				<entropy>-31.26</entropy>
 			</mismatch>
 			<mismatch sequence="RG/YA" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-7600.0</enthalpy>
 				<entropy>-21.28</entropy>
 			</mismatch>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.83</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="1xn_n>3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-8600.0</enthalpy>
 				<entropy>-24.18</entropy>
 			</mismatch>
 			<mismatch sequence="YG/RA" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-7600.0</enthalpy>
 				<entropy>-21.28</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1x1" type="first_non_canonical_pair">
 				<enthalpy>-7900.0</enthalpy>
 				<entropy>-17.09</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-14.83</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1xn_n>3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-9000.0</enthalpy>
 				<entropy>-26.76</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>2800.0</enthalpy>
 				<entropy>12.25</entropy>
 			</mismatch> 			
 			<mismatch sequence="U/U" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-10100.0</enthalpy>
 				<entropy>-29.99</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="1xn_n>3" type="first_non_canonical_pair">
 				<enthalpy>0.0</enthalpy>
 				<entropy>0.0</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="2x3" type="first_non_canonical_pair">
 				<enthalpy>-6400.0</enthalpy>
 				<entropy>-19.35</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="others_non_2x2" type="first_non_canonical_pair">
 				<enthalpy>-5800.0</enthalpy>
 				<entropy>-16.77</entropy>
 			</mismatch>
 			<mismatch sequence="RU/YU" loop="1x1" type="first_non_canonical_pair">
 				<enthalpy>-3400.0</enthalpy>
 				<entropy>-9.67</entropy>
 			</mismatch>
 		</origine>
 		
   		<origine article="Znosko_2007">
       <!--/******************************************************************************/
    	/* contains the parameters for RNA/RNA 1x2 inetrnal loop of ;
	REF: Brent M Znosko et al (2007). Biochemistry 46: 14715-14724. 
    	/******************************************************************************/-->
   			 <mismatch type="initiation">
 				<enthalpy>3200.0<enthalpy>
 				<entropy>3.1</entropy>
 			</mismatch>
 			
 			<penalty type="per_AU_GU_closure">
 				<enthalpy>-3500.0<enthalpy>
 				<entropy>-13.6</entropy>
 			</penalty>
 			
 			<mismatch sequence="A/G_not_RA/YG" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-6300.0</enthalpy>
 				<entropy>-16.2</entropy>
 			</mismatch>
 			<mismatch sequence="G/G" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-6300.0</enthalpy>
 				<entropy>-16.2</entropy>
 			</mismatch>
 			<mismatch sequence="U/U" loop="1x2" type="first_non_canonical_pair">
 				<enthalpy>-11900.0</enthalpy>
 				<entropy>-35.5</entropy>
 			</mismatch>
   		</origine>
   	</mismatches>
   </hybridization>
     		