<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
/*       it under the terms of the GNU General Public License as published by */
/*       the Free Software Foundation; either version 2 of the License, or    */
/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
/*       MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU    */
/*       General Public License for more details.                             */

/*       You should have received a copy of the GNU General Public License    */
/*       along with this program; if not, write to the Free Software          */
/*       Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307 */
/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<!--/*******************************************************************************/
    contains the parameters for DNA/DNA hybridisation of SantaLucia et al.     */
/* (1996). Biochemistry 35 : 3555-3562                                        */
/******************************************************************************/-->

	<data type="crick">
		<neighbor sequence="AA/TT">
	        <enthalpy>-8400.0</enthalpy>
            <entropy>-23.6</entropy>
	    </neighbor> 
	    <neighbor sequence="AC/TG">
	        <enthalpy>-8600.0</enthalpy>
            <entropy>-23.0</entropy>
	    </neighbor> 
	    <neighbor sequence="AG/TC">
	        <enthalpy>-6100.0</enthalpy>
            <entropy>-16.1</entropy>
	    </neighbor> 
	    <neighbor sequence="AT/TA">
	        <enthalpy>-6500.0</enthalpy>
            <entropy>-18.8</entropy>
	    </neighbor>      
        <neighbor sequence="CA/GT">
	        <enthalpy>-7400.0</enthalpy>
            <entropy>-19.3</entropy>
	    </neighbor> 
	    <neighbor sequence="CC/GG">
	        <enthalpy>-6700.0</enthalpy>
            <entropy>-15.6</entropy>
	    </neighbor> 
	    <neighbor sequence="CG/GC">
	        <enthalpy>-10100.0</enthalpy>
            <entropy>-25.5</entropy>
	    </neighbor> 
	    <neighbor sequence="GA/CT">
	        <enthalpy>-7700.0</enthalpy>
            <entropy>-20.3</entropy>
	    </neighbor> 
	    <neighbor sequence="GC/CG">
	        <enthalpy>-11100.0</enthalpy>
            <entropy>-28.4</entropy>
	    </neighbor> 
	    <neighbor sequence="TA/AT">
	        <enthalpy>-6300.0</enthalpy>
            <entropy>-18.5</entropy>
	    </neighbor>
        
        <initiation type="one_GC_Pair">
            <enthalpy>0.0</enthalpy>
            <entropy>-5.9</entropy>
        </initiation>  
        <initiation type="all_AT_pairs">
            <enthalpy>0.0</enthalpy>
            <entropy>-9.0</entropy>
        </initiation> 
        
        <terminal type="5_T/A">
            <enthalpy>400.0</enthalpy>
            <entropy>0.0</entropy>
        </terminal> 
        
        <symmetry>
            <enthalpy>0.0</enthalpy>
            <entropy>-1.4</entropy>
        </symmetry> 
      </data> 