<?xml version="1.0" encoding="ISO-8859-1"?>
<!--
/*      This program is free software; you can redistribute it and/or modify  */
/*       it under the terms of the GNU General Public License as published by */
/*       the Free Software Foundation; either version 2 of the License, or    */
/*       (at your option) any later version.                                  */

/*       This program is distributed in the hope that it will be useful, but  */
/*       WITHOUT ANY WARRANTY; without even the implied warranty of           */
/*       MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU    */
/*       General Public License for more details.                             */

/*       You should have received a copy of the GNU General Public License    */
/*       along with this program; if not, write to the Free Software          */
/*       Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA  02111-1307 */
/*       USA                                                                  */

/*       Marine Dumousseau                                                    */
/*       EMBL-EBI, neurobiology computational group,                          */
/*       Cambridge, UK. e-mail: marine@ebi.ac.uk                   */
-->

<!--/******************************************************************************/
    /* contains the parameters for DNA/DNA single mismatches with locked acid nucleic of
    /* - Owczarzy et al.(2011). Biochemistry 2011, 50, 9352-9367  */
    /******************************************************************************/-->

<data type="mismatch_modified_nucleotides">
    <modified   sequence="ALAL/AT">
        <enthalpy>-3826.0</enthalpy>
        <entropy>-13.109</entropy>
    </modified>
    <modified   sequence="ALCL/AG">
        <enthalpy>-2367.0</enthalpy>
        <entropy>-7.322</entropy>
    </modified>
    <modified   sequence="ALGL/AC">
        <enthalpy>-4849.0</enthalpy>
        <entropy>-13.007</entropy>
    </modified>
    <modified   sequence="ALTL/AA">
        <enthalpy>-5049.0</enthalpy>
        <entropy>-17.514</entropy>
    </modified>
    <modified   sequence="ALAL/TA">
        <enthalpy>-4229.0</enthalpy>
        <entropy>-15.160</entropy>
    </modified>
    <modified   sequence="CLAL/GA">
        <enthalpy>-5878.0</enthalpy>
        <entropy>-17.663</entropy>
    </modified>
    <modified   sequence="CLAL/CA">
        <enthalpy>-8558.0</enthalpy>
        <entropy>-23.976</entropy>
    </modified>
    <modified   sequence="TLAL/AA">
        <enthalpy>2074.0</enthalpy>
        <entropy>3.446</entropy>
    </modified>
    <modified   sequence="CLAL/CT">
        <enthalpy>2218.0</enthalpy>
        <entropy>4.750</entropy>
    </modified>
    <modified   sequence="CLCL/CG">
        <enthalpy>1127.0</enthalpy>
        <entropy>1.826</entropy>
    </modified>
    <modified   sequence="CLGL/CC">
        <enthalpy>-10903.0</enthalpy>
        <entropy>-32.025</entropy>
    </modified>
    <modified   sequence="CLTL/CA">
        <enthalpy>-2053.0</enthalpy>
        <entropy>-10.517</entropy>
    </modified>
    <modified   sequence="ALCL/TC">
        <enthalpy>1065.0</enthalpy>
        <entropy>-1.403</entropy>
    </modified>
    <modified   sequence="CLCL/GC">
        <enthalpy>-9522.0</enthalpy>
        <entropy>-27.024</entropy>
    </modified>
    <modified   sequence="GLCL/CC">
        <enthalpy>-4767.0</enthalpy>
        <entropy>-14.897</entropy>
    </modified>
    <modified   sequence="TLCL/AC">
        <enthalpy>4114.0</enthalpy>
        <entropy>9.258</entropy>
    </modified>
    <modified   sequence="GLAL/GT">
        <enthalpy>-2920.0</enthalpy>
        <entropy>-9.387</entropy>
    </modified>
    <modified   sequence="GLCL/GG">
        <enthalpy>-8139.0</enthalpy>
        <entropy>-21.784</entropy>
    </modified>
    <modified   sequence="GLGL/GC">
        <enthalpy>-5149.0</enthalpy>
        <entropy>-12.508</entropy>
    </modified>
    <modified   sequence="GLTL/GA">
        <enthalpy>-8991.0</enthalpy>
        <entropy>-27.311</entropy>
    </modified>
    <modified   sequence="ALGL/TG">
        <enthalpy>-4980.0</enthalpy>
        <entropy>-15.426</entropy>
    </modified>
    <modified   sequence="CLGL/GG">
        <enthalpy>-4441.0</enthalpy>
        <entropy>-12.158</entropy>
    </modified>
    <modified   sequence="GLGL/CG">
        <enthalpy>-13505.0</enthalpy>
        <entropy>-36.021</entropy>
    </modified>
    <modified   sequence="TLGL/AG">
        <enthalpy>-2775.0</enthalpy>
        <entropy>-9.286</entropy>
    </modified>
    <modified   sequence="TLAL/TT">
        <enthalpy>-3744.0</enthalpy>
        <entropy>-12.149</entropy>
    </modified>
    <modified   sequence="TLCL/TG">
        <enthalpy>-4387.0</enthalpy>
        <entropy>-13.520</entropy>
    </modified>
    <modified   sequence="TLGL/TC">
        <enthalpy>-6346.0</enthalpy>
        <entropy>-16.629</entropy>
    </modified>
    <modified   sequence="TLTL/TA">
        <enthalpy>-7697.0</enthalpy>
        <entropy>-25.049</entropy>
    </modified>
    <modified   sequence="ALTL/TT">
        <enthalpy>-4207.0</enthalpy>
        <entropy>-14.307</entropy>
    </modified>
    <modified   sequence="CLTL/GT">
        <enthalpy>-8176.0</enthalpy>
        <entropy>-22.962</entropy>
    </modified>
    <modified   sequence="GLTL/CT">
        <enthalpy>-7241.0</enthalpy>
        <entropy>-20.622</entropy>
    </modified>
    <modified   sequence="TLTL/AT">
        <enthalpy>-2051.0</enthalpy>
        <entropy>-7.055</entropy>
    </modified>
    <modified   sequence="ALAL/CT">
        <enthalpy>-1362.0</enthalpy>
        <entropy>-5.551</entropy>
    </modified>
    <modified   sequence="ALCL/CG">
        <enthalpy>-1759.0</enthalpy>
        <entropy>-6.511</entropy>
    </modified>
    <modified   sequence="ALGL/CC">
        <enthalpy>-6549.0</enthalpy>
        <entropy>-18.073</entropy>
    </modified>
    <modified   sequence="ALTL/CA">
        <enthalpy>-3563.0</enthalpy>
        <entropy>-14.105</entropy>
    </modified>
    <modified   sequence="ALAL/TC">
        <enthalpy>-2078.0</enthalpy>
        <entropy>-10.088</entropy>
    </modified>
    <modified   sequence="CLAL/GC">
        <enthalpy>-5868.0</enthalpy>
        <entropy>-16.952</entropy>
    </modified>
    <modified   sequence="GLAL/CC">
        <enthalpy>-8477.0</enthalpy>
        <entropy>-24.565</entropy>
    </modified>
    <modified   sequence="TLAL/AC">
        <enthalpy>2690.0</enthalpy>
        <entropy>4.965</entropy>
    </modified>
    <modified   sequence="CLAL/AT">
        <enthalpy>-9844.0</enthalpy>
        <entropy>-29.673</entropy>
    </modified>
    <modified   sequence="CLCL/AG">
        <enthalpy>-3761.0</enthalpy>
        <entropy>-11.204</entropy>
    </modified>
    <modified   sequence="CLGL/AC">
        <enthalpy>-9845.0</enthalpy>
        <entropy>-27.316</entropy>
    </modified>
    <modified   sequence="CLTL/AA">
        <enthalpy>-3389.0</enthalpy>
        <entropy>-12.517</entropy>
    </modified>
    <modified   sequence="ALCL/TA">
        <enthalpy>753.0</enthalpy>
        <entropy>-0.503</entropy>
    </modified>
    <modified   sequence="CLCL/GA">
        <enthalpy>-12714.0</enthalpy>
        <entropy>-35.555</entropy>
    </modified>
    <modified   sequence="GLCL/CA">
        <enthalpy>-12658.0</enthalpy>
        <entropy>-35.729</entropy>
    </modified>
    <modified   sequence="TLCL/AA">
        <enthalpy>-1719.0</enthalpy>
        <entropy>-7.023</entropy>
    </modified>
    <modified   sequence="ALAL/GT">
        <enthalpy>2193.0</enthalpy>
        <entropy>4.374</entropy>
    </modified>
    <modified   sequence="ALCL/GG">
        <enthalpy>-8453.0</enthalpy>
        <entropy>-22.672</entropy>
    </modified>
    <modified   sequence="ALGL/GC">
        <enthalpy>-1164.0</enthalpy>
        <entropy>-2.532</entropy>
    </modified>
    <modified   sequence="ALTL/GA">
        <enthalpy>-7418.0</enthalpy>
        <entropy>-24.066</entropy>
    </modified>
    <modified   sequence="ALAL/TG">
        <enthalpy>-1963.0</enthalpy>
        <entropy>-9.013</entropy>
    </modified>
    <modified   sequence="CLAL/GG">
        <enthalpy>-8712.0</enthalpy>
        <entropy>-23.779</entropy>
    </modified>
    <modified   sequence="GLAL/CG">
        <enthalpy>-7875.0</enthalpy>
        <entropy>-21.661</entropy>
    </modified>
    <modified   sequence="TLAL/AG">
        <enthalpy>3207.0</enthalpy>
        <entropy>7.156</entropy>
    </modified>
    <modified   sequence="GLAL/AT">
        <enthalpy>-2914.0</enthalpy>
        <entropy>-9.402</entropy>
    </modified>
    <modified   sequence="GLCL/AG">
        <enthalpy>-9131.0</enthalpy>
        <entropy>-25.347</entropy>
    </modified>
    <modified   sequence="GLGL/AC">
        <enthalpy>-2154.0</enthalpy>
        <entropy>-3.871</entropy>
    </modified>
    <modified   sequence="GLTL/AA">
        <enthalpy>-8515.0</enthalpy>
        <entropy>-26.313</entropy>
    </modified>
    <modified   sequence="ALGL/TA">
        <enthalpy>-6691.0</enthalpy>
        <entropy>-21.148</entropy>
    </modified>
    <modified   sequence="CLGL/GA">
        <enthalpy>-3960.0</enthalpy>
        <entropy>-10.588</entropy>
    </modified>
    <modified   sequence="GLGL/CA">
        <enthalpy>-12898.0</enthalpy>
        <entropy>-34.656</entropy>
    </modified>
    <modified   sequence="TLGL/AA">
        <enthalpy>334.0</enthalpy>
        <entropy>-0.440</entropy>
    </modified>
    <modified   sequence="CLAL/TT">
        <enthalpy>382.0</enthalpy>
        <entropy>-0.579</entropy>
    </modified>
    <modified   sequence="CLCL/TG">
        <enthalpy>-2716.0</enthalpy>
        <entropy>-8.000</entropy>
    </modified>
    <modified   sequence="CLGL/TC">
        <enthalpy>-10363.0</enthalpy>
        <entropy>-29.315</entropy>
    </modified>
    <modified   sequence="CLTL/TA">
        <enthalpy>-5783.0</enthalpy>
        <entropy>-20.173</entropy>
    </modified>
    <modified   sequence="ALCL/TT">
        <enthalpy>-692.0</enthalpy>
        <entropy>-5.278</entropy>
    </modified>
    <modified   sequence="CLCL/GT">
        <enthalpy>-10288.0</enthalpy>
        <entropy>-28.503</entropy>
    </modified>
    <modified   sequence="GLCL/CT">
        <enthalpy>-9062.0</enthalpy>
        <entropy>-26.356</entropy>
    </modified>
    <modified   sequence="TLCL/AT">
        <enthalpy>2073.0</enthalpy>
        <entropy>3.968</entropy>
    </modified>
    <modified   sequence="TLAL/CT">
        <enthalpy>-5485.0</enthalpy>
        <entropy>-17.347</entropy>
    </modified>
    <modified   sequence="TLCL/CG">
        <enthalpy>1451.0</enthalpy>
        <entropy>1.556</entropy>
    </modified>
    <modified   sequence="TLGL/CC">
        <enthalpy>-7213.0</enthalpy>
        <entropy>-20.128</entropy>
    </modified>
    <modified   sequence="TLTL/CA">
        <enthalpy>-2397.0</enthalpy>
        <entropy>-11.371</entropy>
    </modified>
    <modified   sequence="ALTL/TC">
        <enthalpy>-633.0</enthalpy>
        <entropy>-5.801</entropy>
    </modified>
    <modified   sequence="CLTL/GC">
        <enthalpy>-6868.0</enthalpy>
        <entropy>-21.000</entropy>
    </modified>
    <modified   sequence="GLTL/CC">
        <enthalpy>-5853.0</enthalpy>
        <entropy>-16.643</entropy>
    </modified>
    <modified   sequence="TLTL/AC">
        <enthalpy>211.0</enthalpy>
        <entropy>-1.446</entropy>
    </modified>
    <modified   sequence="GLAL/TT">
        <enthalpy>-5551.0</enthalpy>
        <entropy>-15.398</entropy>
    </modified>
    <modified   sequence="GLCL/TG">
        <enthalpy>-14943.0</enthalpy>
        <entropy>-40.148</entropy>
    </modified>
    <modified   sequence="GLGL/TC">
        <enthalpy>-8110.0</enthalpy>
        <entropy>-18.349</entropy>
    </modified>
    <modified   sequence="GLTL/TA">
        <enthalpy>-14293.0</enthalpy>
        <entropy>-40.148</entropy>
    </modified>
    <modified   sequence="GLGL/TC">
        <enthalpy>-8110.0</enthalpy>
        <entropy>-18.349</entropy>
    </modified>
    <modified   sequence="GLTL/TA">
        <enthalpy>-14213.0</enthalpy>
        <entropy>-40.041</entropy>
    </modified>
    <modified   sequence="ALGL/TT">
        <enthalpy>-7130.0</enthalpy>
        <entropy>-20.786</entropy>
    </modified>
    <modified   sequence="CLGL/GT">
        <enthalpy>-14862.0</enthalpy>
        <entropy>-39.430</entropy>
    </modified>
    <modified   sequence="GLGL/CT">
        <enthalpy>-14622.0</enthalpy>
        <entropy>-37.510</entropy>
    </modified>
    <modified   sequence="TLGL/AT">
        <enthalpy>-6703.0</enthalpy>
        <entropy>-18.111</entropy>
    </modified>
    <modified   sequence="TLAL/GT">
        <enthalpy>-4612.0</enthalpy>
        <entropy>-14.039</entropy>
    </modified>
    <modified   sequence="TLCL/GG">
        <enthalpy>-9798.0</enthalpy>
        <entropy>-26.406</entropy>
    </modified>
    <modified   sequence="TLGL/GC">
        <enthalpy>-4519.0</enthalpy>
        <entropy>-11.065</entropy>
    </modified>
    <modified   sequence="TLTL/GA">
        <enthalpy>-4523.0</enthalpy>
        <entropy>-15.693</entropy>
    </modified>
    <modified   sequence="ALTL/TG">
        <enthalpy>-2364.0</enthalpy>
        <entropy>-8.834</entropy>
    </modified>
    <modified   sequence="CLTL/GG">
        <enthalpy>-11396.0</enthalpy>
        <entropy>-30.732</entropy>
    </modified>
    <modified   sequence="GLTL/CG">
        <enthalpy>-6233.0</enthalpy>
        <entropy>-15.933</entropy>
    </modified>
    <modified   sequence="TLTL/AG">
        <enthalpy>-2960.0</enthalpy>
        <entropy>-9.305</entropy>
    </modified>
</data>
