# STOCKHOLM 1.0
#=GF ID   SMC_N
#=GF AC   PF02463.10
#=GF DE   RecF/RecN/SMC N terminal domain
#=GF AU   Bateman A
#=GF SE   [1]
#=GF GA   -95.80 -95.80; 24.40 24.40;
#=GF TC   -95.80 -95.80; 24.40 24.40;
#=GF NC   -95.90 -95.90; 24.30 24.30;
#=GF TP   Family
#=GF BM   hmmbuild -F --hand HMM_ls SEED
#=GF BM   hmmcalibrate --seed 0 HMM_ls
#=GF BM   hmmbuild -f -F --hand HMM_fs SEED
#=GF BM   hmmcalibrate --seed 0 HMM_fs
#=GF AM   globalfirst
#=GF NE   PF04423;
#=GF NL   Q12267/295-1321;
#=GF NE   PF06470;
#=GF NL   Q12267/295-1321;
#=GF RN   [1]
#=GF RM   10429180
#=GF RT   Structural maintenance of chromosomes (SMC) proteins:
#=GF RT   conserved molecular properties for multiple biological
#=GF RT   functions. 
#=GF RA   Strunnikov AV, Jessberger R; 
#=GF RL   Eur J Biochem 1999;263:6-13.
#=GF RN   [2]
#=GF RM   9640531
#=GF RT   SMC protein complexes and higher-order chromosome dynamics. 
#=GF RA   Hirano T; 
#=GF RL   Curr Opin Cell Biol 1998;10:317-322.
#=GF DR   PROSITE; PDOC00539;
#=GF DR   HOMSTRAD; ABC_tran;
#=GF DR   SCOP; 1f2t; fa;
#=GF DC   The following Pfam-B families contain sequences that according to Prodom
#=GF DC   are members of this Pfam-A family.
#=GF DR   PFAMB; PB001893;
#=GF DR   PFAMB; PB003601;
#=GF DR   PFAMB; PB004206;
#=GF DR   PFAMB; PB006729;
#=GF DR   PFAMB; PB007921;
#=GF DR   PFAMB; PB010201;
#=GF DR   PFAMB; PB010634;
#=GF DR   PFAMB; PB011218;
#=GF DR   PFAMB; PB013203;
#=GF DR   PFAMB; PB014228;
#=GF DR   PFAMB; PB017035;
#=GF DR   PFAMB; PB018409;
#=GF DR   PFAMB; PB020745;
#=GF DR   PFAMB; PB031758;
#=GF DR   PFAMB; PB033991;
#=GF DR   PFAMB; PB034984;
#=GF DR   PFAMB; PB035877;
#=GF DR   PFAMB; PB035900;
#=GF DR   PFAMB; PB037220;
#=GF DR   PFAMB; PB037301;
#=GF DR   PFAMB; PB052451;
#=GF DR   PFAMB; PB056231;
#=GF DR   PFAMB; PB064277;
#=GF DR   PFAMB; PB069590;
#=GF DR   PFAMB; PB075176;
#=GF DR   PFAMB; PB087283;
#=GF DR   PFAMB; PB089380;
#=GF DR   PFAMB; PB093956;
#=GF DR   PFAMB; PB094898;
#=GF DR   PFAMB; PB106945;
#=GF DR   PFAMB; PB111651;
#=GF DR   PFAMB; PB119733;
#=GF DR   PFAMB; PB119735;
#=GF DR   PFAMB; PB120277;
#=GF DR   PFAMB; PB125166;
#=GF DR   PFAMB; PB126624;
#=GF DR   PFAMB; PB128189;
#=GF DR   PFAMB; PB133582;
#=GF DR   PFAMB; PB142666;
#=GF DR   PFAMB; PB152346;
#=GF DR   PFAMB; PB152493;
#=GF DR   PFAMB; PB153693;
#=GF DR   PFAMB; PB156411;
#=GF DR   PFAMB; PB156457;
#=GF DR   PFAMB; PB168691;
#=GF DR   PFAMB; PB169449;
#=GF DR   PFAMB; PB169485;
#=GF DR   PFAMB; PB169520;
#=GF DR   PFAMB; PB169867;
#=GF DR   PFAMB; PB169874;
#=GF DR   PFAMB; PB170016;
#=GF DR   PFAMB; PB170063;
#=GF DR   PFAMB; PB170128;
#=GF DR   PFAMB; PB170619;
#=GF DR   PFAMB; PB170867;
#=GF DR   PFAMB; PB171494;
#=GF DR   PFAMB; PB171917;
#=GF DR   PFAMB; PB172115;
#=GF DR   PFAMB; PB172415;
#=GF DR   PFAMB; PB172563;
#=GF DR   PFAMB; PB172567;
#=GF DR   PFAMB; PB172923;
#=GF DR   PFAMB; PB173552;
#=GF DR   PFAMB; PB173779;
#=GF DR   PFAMB; PB173783;
#=GF DR   PFAMB; PB173881;
#=GF DR   PFAMB; PB174322;
#=GF DR   PFAMB; PB175475;
#=GF DR   PFAMB; PB175696;
#=GF DR   PFAMB; PB175744;
#=GF DR   PFAMB; PB176033;
#=GF DR   PFAMB; PB176065;
#=GF DR   PFAMB; PB176151;
#=GF DR   PFAMB; PB176204;
#=GF DR   PFAMB; PB176886;
#=GF DR   PFAMB; PB176948;
#=GF DR   PFAMB; PB177206;
#=GF DR   PFAMB; PB177262;
#=GF DR   PFAMB; PB177311;
#=GF DR   PFAMB; PB177501;
#=GF DR   PFAMB; PB177602;
#=GF DR   PFAMB; PB178745;
#=GF DR   PFAMB; PB179645;
#=GF DR   PFAMB; PB179788;
#=GF DR   PFAMB; PB180891;
#=GF DR   PFAMB; PB180976;
#=GF DR   PFAMB; PB181268;
#=GF DR   PFAMB; PB181451;
#=GF DR   PFAMB; PB181494;
#=GF DR   PFAMB; PB181922;
#=GF DR   PFAMB; PB182299;
#=GF DR   PFAMB; PB182468;
#=GF DR   PFAMB; PB182487;
#=GF DR   INTERPRO; IPR003395;
#=GF CC   This domain is found at the N terminus of SMC proteins.
#=GF CC   The SMC (structural maintenance of chromosomes) superfamily
#=GF CC   proteins have ATP-binding domains at the N- and
#=GF CC   C-termini, and two extended coiled-coil domains separated by
#=GF CC   a hinge in the middle.  The eukaryotic SMC proteins form two
#=GF CC   kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types.
#=GF CC   These heterodimers constitute an essential part of higher
#=GF CC   order complexes, which are involved in chromatin and DNA
#=GF CC   dynamics [1]. 
#=GF CC   This family also includes the RecF and RecN proteins that
#=GF CC   are involved in DNA metabolism and recombination.
#=GF SQ   29
#=GS RECF_PSEPU/2-358      AC P13456.2
#=GS RECF_ECOLI/2-356      AC P0A7H0.2
#=GS RECF_PROMI/2-359      AC P22839.1
#=GS RECF_ACTPL/2-359      AC P24718.1
#=GS RECF_HAEIN/2-356      AC P43767.1
#=GS P115_MYCHR/3-961      AC P41508.2
#=GS SMC_BACSU/2-1172      AC P51834.2
#=GS P115_MYCPN/3-963      AC P75361.1
#=GS O83382_TREPA/3-919    AC O83382.1
#=GS SMC_MYCTU/2-1186      AC Q10970.2
#=GS O28714_ARCFU/2-1148   AC O28714.1
#=GS SMC_METJA/3-1163      AC Q59037.2
#=GS O59462_PYRHO/3-1151   AC O59462.1
#=GS O66878_AQUAE/6-1140   AC O66878.1
#=GS P73340_SYNY3/3-1194   AC P73340.1
#=GS O51074_BORBU/6-815    AC O51074.1
#=GS SMC2_YEAST/2-1166     AC P38989.1
#=GS SMC2_CHICK/2-1167     AC Q90988.1
#=GS SUDA_EMENI/2-1193     AC Q00737.1
#=GS Q24098_DROME/33-1211  AC Q24098.1
#=GS SMC3_YEAST/2-1208     AC P47037.1
#=GS SMC4_YEAST/155-1406   AC Q12267.1
#=GS SMC4_SCHPO/125-1313   AC P41004.2
#=GS SMC4_XENLA/77-1268    AC P50532.1
#=GS DPY27_CAEEL/92-1330   AC P48996.1
#=GS SMC4_CAEEL/91-1361    AC Q20060.1
#=GS SMC1A_HUMAN/3-1212    AC Q14683.2
#=GS O01789_CAEEL/15-1251  AC O01789.3
#=GS SMC1_YEAST/3-1212     AC P32908.1
#=GS SMC1_YEAST/3-1212     DR PDB; 1w1w A; 3-1198;
#=GS SMC1_YEAST/3-1212     DR PDB; 1w1w B; 3-1198;
#=GS SMC1_YEAST/3-1212     DR PDB; 1w1w D; 3-1198;
#=GS SMC1_YEAST/3-1212     DR PDB; 1w1w C; 3-1198;
RECF_PSEPU/2-358                 SLRRIMVTAVRNL..HPVTLLPSPRINILYGANGSGKTSVLEAV.HLLG...LARSFRSTRLNPVIQY...............EQAACTVFGEVQLT...........EGGT................SNLGVSRERQGE...FTIRI........DGQNARQ.AQLAELLPLQLINPDs..........frllegapkirr.......qfld..wgvfhveprflpawqrlqk......................................................................................................................................................................................................................................................................................................................................................................................................................................................alrqrns..................................................................................wlrhgtld.................................................................................................................................................................................................................................................pasqaawdrelclrsaeideyrrnyikal........................................................................................................................................................................................................kpvfertlselvel.dgltlsyyrgwdkdrelqevlassllrdqqmghtq............................................agpqradlrlrlagnnaa.................................................dILSRGQQKLVGMRII.AQGHLVSQARRGHCIYLVDDLPSELDDQHRRALCRLLE..ELR...CQVFITCVDHELLREGW.QTETPVALFHVEQGRIT
RECF_ECOLI/2-356                 SLTRLLIRDFRNI..ETADLALSPGFNFLVGANGSGKTSVLEAI.YTLG...HGRAFRSLQIGRVIRH...............EQEAFVLHGRLQG............EERE................TAIGLTKDKQGD...SKVRI........DGTDGHKVAELAHLMPMQLITPEg..........ftllnggpkyrr.......afld..wgcfhnepgfftawsnlkr......................................................................................................................................................................................................................................................................................................................................................................................................................................................llkqrna..................................................................................alrqvtr..................................................................................................................................................................................................................................................yeqlrpwdkeliplaeqistwraeysagia.......................................................................................................................................................................................................admadtckqflpef..sltfsfqrgweketeyaevlernferdrqltyta............................................hgphkadlriradgapve.................................................dTLSRGQLKLLMCALRLAQGEFLTRESGRRCLYLIDDFASELDDERRGLLASRLK..ATQ...SQVFVSAISAEHVIDM...SDENSKMFTVEKGKIT
RECF_PROMI/2-359                 ILSRLLIRHFRNI..EQADLPLADGFNFLVGPNGSGKTSILEAI.YTLG...HGRAFRSAQANRVIQH...............DENAFILHGRLSGL.........DEESRG................YSIGLSKDREGN...STVRI........DGSDGHKIAELAKLLPMQLITPEg..........ftllnggpkyrr.......afid..wgcfhneprffaawsdlkr......................................................................................................................................................................................................................................................................................................................................................................................................................................................vlkqrna..................................................................................alrqass..................................................................................................................................................................................................................................................yrqllpwdkelillteqisqwraeytedia.......................................................................................................................................................................................................kdieetcqlflpef..tlkvsfqrgwdketdyaqllerqferdkvlsyts............................................lgahkadlrirangtpve.................................................dMLSRGQLKLLMCALRLAQGEYFTRKNGQRCLYLLDDFASELDANRRQLLAERLK..STQ...AQVFVSAITSGQVKDM...LDVNSRLFSVEHGKIE
RECF_ACTPL/2-359                 PLSRLIINNFRNL..QSLDLELSPNFNFIVGHNGSGKTSLLEAI.FYLG...HGRSFKSHISNRIIHY...............QAEDFVLHARIDE............GQHQ................WSVGIQKKRSGD...TLLKI........NGEDGNKISDLAHLLPMQVITPEg..........ltllnggptfrr.......afld..wglfhqytefyscwanlkr......................................................................................................................................................................................................................................................................................................................................................................................................................................................llkqrna..................................................................................alhqvrs..................................................................................................................................................................................................................................................yaelkpwdielaklaeivsqmrasyaeglr.......................................................................................................................................................................................................peiektcqfflpel..eigvsfhqgwekgtdyaeilaqgferdkamgytm............................................igpqkadfrfranglpve.................................................dVLSRGQLKLLMCALRLAQGEYLVAQKERQCLFLIDDFASELDPIKRELLAHRLR..ESG...SQVFVTAITKDQLNQMQWQESEQDSLFQVQQGMLT
RECF_HAEIN/2-356                 AISRLLVEKFRNL..TAVDLDFDPCFNFLIGNNGSGKTSLLEAI.FYLG...HGRSFKSAVTNRIISY...............DEPHFTLFGQIQE............SQHQ................WSIGLQKLRQGN...TLVKI........NGEDGNKISDLAHLLPMQLITPEg..........ltllnggpsyrr.......afld..wglfhhqtsfysawsnlnr......................................................................................................................................................................................................................................................................................................................................................................................................................................................llkqrna..................................................................................alaqnqp..................................................................................................................................................................................................................................................ysaikiwdvelaklahqvsewraeyaeals.......................................................................................................................................................................................................peieqtcqlflpel..einvsfhqgweknadyyeilqqnferdralnytf............................................sgpqkadfrfkaqglpve.................................................dVLSRGQLKLLMCALRLAQGEHLMKEKQRHCIFLIDDFASELDQYKRALLAERLQ..QSG...SQVFVTAITQRQLKEM...QVENKKMFSVHNGIIN
P115_MYCHR/3-961                 KLIKIEIEGFKSFA.DPISINFDGSVVGIVGPNGSGKSNINDAIRWVLGEQ.SAKQLRGLNMDDVIFAG.............SKTVKPQEKAMVKLTF........KNEDAI..........EETKQIFTISRLLKRGQGT..NEYFY........NDQPVRY.KDIKNLAVESGISKSs.laiisqgtiseiaeatpeqrk.......avieeaagtskykldkeeaqkklirtndaidklqgai.kelerqvnsldkqaskakiylekskalesvevglivndlnffneklnnlntslle..............veqqrndlelniqtyessisqtvhfktevessiqei.tsk..ldnlknalse.inlqearieerrkliisg.....eivvdqktkieeikkqveslkiq............................................................................................inaskqre..ieldqqltrlna.kanslklqendinkeig......vllekksaaaaninilkqqfenksflskgiktik...............................dnsflfdgyiglaselfkv...esefslaietvlgaalnqivmktsedvlqaidflkknls.gkatfipltsikerevredhllv.lk..gqkgflgv.akelief.dtqfnklfgfllgnilvvdnvdnanriakildh...kytivsle..gdlfrpggtitggsklertsi.............lnydikikehtntlkfaedqihdlkikqqtiyneietvnstiqqvkieansin.......................................skl........nilneelnnlklnaseifkeqqedq............eslnlsfdseklniekqistltielnskkdrlt..................nliseqgkg.....etkkqeldaklrklntqhsdsiteqnrakflveqnqkrlsehykltleaaseqy.......sldldieqa...............................................................................................................................................................rhfvdslkkelkel.gnvnleaitefeevnqryqekkqyieelttakskieeaisdldkiiinktteivnlvnnefnmvfqkmfg.........gg..kaeihftd...knd.............................ilnsgveisaqppgktiknlrLFSGGEKAIIAISLLFA.....ILKARPIPLCILDEVEAALDESNVIRYVEFLK..LLKEN.TQFLIITHRSGTMSRV....DQLLGVTMQKRGVTS
SMC_BACSU/2-1172                 FLKRLDVIGFKSFA.ERISVDFVKGVTAVVGPNGSGKSNITDAIRWVLGEQ.SARSLRGGKMEDIIFAG.............SDSRKRLNLAEVTLTL........DNDDHF.......LPIDFHE..VSVTRRVYRSGE...SEFLI........NNQPCRL.KDIIDLFMDSGLGKEa.fsiisqgkveeilsskaedrr.......sifeeaagvlkyktrkkkaenklfetqdnlnrvedil.helegqveplkiqasiakdylekkkelehveialtaydieklhgkwstlkekvqm..............akeeelaessaisakeakiedtrdkiqaldesvnel.qqv..llvtseelek.legrkevlkerkknavqnqeqleeaivqfqqketvlkeelskqeav....fetlqaevkqlraqvkekqqalslhnenveekieqlksdyfellnsqasirnelqllddqmsqsavtlqrladnnekhlqerhdisarkaacetef..arieqeihsqvg.ayrdmqtkyeqkkrqye......knesalyqayqyvqqarskkdmletmqgdfsgfyqgvkevl........................kakerlggirgavlelist...eqkyetaieialgasaqhvvtddeqsarkaiqylkqnsf.gratflplsvirdrqlqsrdaet.aa..rhssflgv.aselvtf.dpayrsviqnllgtvlitedlkganelakllgh...ryrivtle..gdvvnpggsmtggavkkknnsllgrsrel.....edvtkrlaemeektalleqevktlkhsiqdmekkladlretgeglrlkqqdvkgqlyelqvaekninthlelydqeksals...........esdeerkvrk.rkleeelsavse.kmkqleedidrl............tkqkqtqsstkeslsneltelkiaaakkeqack........geed...nlarlkkeltet.....elalkeakedlsfltsemssstsgeekleeaakhklndktktielialrrdqri.......klqhgldtyerelkemkrlykqkt.tllkdeevklgrmeveldn.llqy.........................lreeysl....................................................sfegakekyqletdpeea.................rkrvkliklaieel.gtvnlgsidefervnerykflseqkedlteakntlfqvieemdeemtkrfndtfvqirshfdqvfrslfg.........gg..raelrltd...pnd.............................llhsgveiiaqppgkklqnlnLLSGGERALTAIALLFS.....ILKVRPVPFCVLDEVEAALDEANVFRFAQYLK..KYSSD.TQFIVITHRKGTMEEA....DVLYGVTMQESGVSK
P115_MYCPN/3-963                 FLKRFRAYGFKSYA.DEITINFTHSMTGIVGPNGSGKSNVVDALKWVLGER.SMKHLRSKSGDDMIFFG.............SKDKPASKLAEVELTF........DNSQKL.......LHDPRPE..ISVMRRIYRGSGQ..SEYYI........NGELVTL.KEISGIFADIGLEKGs.lgiisqgsvswfveakpeerr.......kifedasgigrytkrkeevtnqlartvqnlkqvsivl.nelkkdlkkltiqadkaqrfvklkeelkelelsvlvadylksqgeldrfnhqigy..............ieqdfklhepqlqlledqlnifnqrfrdadeqsikl.qqe..lqavyqtine.leqrkavidvqlknelsk........kdekhkiqalkklirvdqaq...................................................................................................l..eslqaqvlktts.eitlltnelstvqteld......ttklnlnqnsaalvyqqaqqeflkaqneewvktnpah............................vlvknvkaltgllntlntflkfekqyekallkalgksigylvvnnnlaalkaidflltnqi.gqvtflpiddiafd.tkiapehm.eilqqldgflgv.gsdhvsc.deslqpivnallgqviiasdlqaalklssytyk...lyrvvtln..getvyaggiiqggy....................vkdnlslynlqeklasseanitqlehnekqlrtnltsletklnelnkklkyeeillekfnervnhtnkailsykieyeqltn.....................esfdgtphsfde...trlveslnra.............................................................................waerdelnsqlklnqelketlaksiklaeaktadlralldeqrsqlvlaregki.......rfentihnitdkinggykltmefa.ianynkpiklstmqa................................................................................................................................qnkiarmqsqldem.gpinlesiaeiadkqkrfddingeyeslqtaikdlqtaigeidelackefdeliqkvnaelpktfnylfg.........gg..scqirytd...tdn.............................vllsgievfanppgknvanlmLLSGGEKTLVALSVLFS.....ILRVSAFPLVILDEAESALDPANVERFANIIG..NSSNN.TQFLIITHRQGTMMKC....DMLLGAAMQTKGVTK
O83382_TREPA/3-919               FLKTLEVFGFKSFA.DRVRVEFADGVTALLGPNGCGKSNVVDAIKWVLGEQ.SSRALRADRMEDVIFNG.............TESRRSLNVAEASLTV........CDEAGI.......LSLDVPE..ILIKRRLYRSGE...SEYFL........NGNAVRL.KEIRELFWDTGIGKVa.ysvmeqgkidqilsnkpeerr.......ylfeeaagvtrfkvrgaeaarklektaenlrhlevil.qeveksyessklqaaqtqryrmlkeeifardrdlgllrlrgflenqaradgalqr..............nrarrdalqtqveeaqqtlsarigeindmekrvdal.qke..iyglaieqka.kqneaslhrkhlselkesigqiemrkigvesrvqnleeevaeqdah............................................................................................vyqlgsal..ssveehiesfar.slhvasehvsendqtlr......diqgqmqeisaacveleaslrdva...ediaa.........................................................eldtrlsaagysarnr..aeaertlvagvqrlrtfve.grari................................vsdflvv.dthtegelcrml..ttvvdafneavkivhcvesdiaeyarvsarfidefvapqgimtkk.....................referqleqhraqlerhaarqrtlqeenkllvgkieacrktleslrvdqarlraeaeagqkqaagtrgevarqr..................avikelegel.ftegervaalee.rllevegeigql............eqrgvlltkslencegeirvrnaavtseehalq..................earvelaqv.....grqleqahrelmqceteirnlrehfreqhtr......dlsefedlipgiektas.......dl......................................................................................................................................................................rqergelqarvkei.gavnfmaveefqevkeryeflvaqvadlekaradlqrvtdkikaesaelflatyrrirknfhevfrrlfg.........gg..raeirlsd...paa.............................vlscgieilaqppgkklehigLLSGGEKAMTAVALLFA.....TYMVKPAPFCLLDEIDAALDEHNVARFVGMLD..EFSDV.SQYIVITHNRRTVLGA....RTMLGVTMEEPGVSK
SMC_MYCTU/2-1186                 YLKSLTLKGFKSFA.APTTLRFEPGITAVVGPNGSGKSNVVDALAWVMGEQ.GAKTLRGGKMEDVIFAG.............TSSRAPLGRAEVTVSI........DNSDNA.......LPIEYTE..VSITRRMFRDGA...SEYEI........NGSSCRL.MDVQELLSDSGIGREm.hvivgqgkleeilqsrpedrr.......afieeaagvlkhrkrkekalrkldtmaanlarltdlt.telrrqlkplgrqaeaaqraaaiqadlrdarlrlaaddlvsrraereavfqaeaa..............mrrehdeaaarlavaseelaahesavaelstraesi.qht..wfglsalaer.vdatvriaserahhldiepvavsdtdprkpeeleaeaqqvavaeqq.......llaeldaararldaaraeladrerraaeadrahlaavreeadrregl.arlagqvetmrarvesidesva..........rlseriedaamra..qqtraefetvqg.rigeldqgevgldehhe......rtvaalrladervaelqsaeraae...rqvaslraridalavglqrkdgaawl............ahnrsgaglfgsiaqlvkv...rsgyeaalaaalgpaadalavdgltaagsavsalkqadg.gravlvlsdwpapqapqsasgem.lpsgaqw......aldlves.ppqlvgamiamlsgvavvndlteamglveirp....elravtvd..gdlv.gagwvsggsdrklst..............levtseidkarselaaaealaaqlnaalagalteqsarqdaaeqalaalnesdtaisamyeqlgrlgqearaaeeewnrllqqrteqeavrtqtlddv.....iqletqlrkaqetqrvqvaqpidrqaisaaadra...rgvevearlavrtaeeranavrgradslrraaa.......aerea...rvraqqaraarlhaaavaaavadcgrllagrlhravdgasqlrdasaa......qrqqrlaamaavrdevn.......tlsarvgeltdslhrdelanaqaa...lrieqleqmvleqfgma.padl.........................iteygph...............................................v....alpptelemaefeqarergeqviapapmpfdrvtqerrakraeralael.grvnplaleefaaleerynflstqledvkaarkdllgvvadvdarilqvfndafvdverefrgvftalfp.........gg..egrlrlte...pdd.............................mlttgievearppgkkitrlsLLSGGEKALTAVAMLVA.....IFRARPSPFYIMDEVEAALDDVNLRRLLSLFE..QLREQ.SQIIIITHQKPTMEVA....DALYGVTMQNDGITA
O28714_ARCFU/2-1148              HIEKIRLKNFKSFG.KKAEIPFFKGFTVITGPNGSGKSNIIDSILFCLGLSTSTKQLRAERLTDLVHNG.............R......SEAEVAILF........SENGKK................YEIARKVKITEKGYYSYYYL........NGKSVSL.SEIHSFLSQFGIYSDa.ynvvmqgdvtriiemspfqrr.......kiiddvagisefdekkekaleelervresiekleavi.aevndrlqtlerdrneairykeilskkeeyegylrahnyltavkskekvereler..............lerqkdeltskipeinariaelnekinelaakiselgder..saeiqsrile.lsseleslrraerfyldeakrleeesvkiiseiskikeemesldge...............leeyaikriqvgeivdelaakmellrqrleevdkkhrelrdrlvsrkeelemykerrgeilrerdkliellrridmdvediknei..asiesklkefet.ekkakqeevwkqeeelm......sakkmlssadkklfdirakisdve...delkkaelelakvkatlstlrtyskpveillda.....rnrrelpgifgtvaqlgev...deeyvaaieaaagnalqfvvveteddavsainflkavrg.gratfiplrriksfklsldksil.....kedgvidf.avnlvrc.dkkfqpvfrfilrdtvvvdrietakrlmdr......gfrfvtld..gdiveksglmtggsaekrgilvsrellek....ermlsdkiyelqrekeglfaelnraeslrkqykdevdrltgmiselrnrislldekirtesgrieelrekisqksrekenyi...........sslkdynskl.aemeeaigelea.eieeiermlrgsevpkiveeldkikeehqrnreilisiekkieslefkreqlessmq........ekqv...yldeikdridei.....rrtieegkarveeinseleelrkeerelgkelkglrkerdelikqlrnaeeekr.......kieaeidrleeriklqkerleiae.seiaeigevevpenlpple.kv.........................................................................................................................ekvldevlvelstf.gdvnlkaiqeyeevkarrdelvekkmvlekeradildriekyermkreiffevftainrnfaeiirelan.........g...egelyld....sdd.............................pfnsglyikvkpnnkpvqkleSMSGGEKSLVALALIFA.....IQMYKPAPFYAFDEVDMFLDGVNVGRVAKMIK..KRSKD.AQFIVVSLRKPMLEQA....DAIVGITLGRDNVSQ
SMC_METJA/3-1163                 TLEKIELKNFKSF..KKLSLDIPKGFTAIVGPNGSGKSNIVDAILFVLGKT.SAKKLRANRFSGLITY...............HNGKRADFAEVCLYF........TNENNA.......FNVNADK..VGILRRIKSSGE...TDYYLVWKENDKEKRKKMTK.HEIIDLFRRLGLLGDn...visqgdllkiinispierr.......kiideisgiaefdekkkkaeeelkkareliemidiri.sevennlkklkkekedaekyiklneelkaakyalilkkvsylnvlleniqndikn..............leelkneflskvreidveienlklrlnniinelnekgnee..vlelhksike.leveiendkkvldssinelkkveveienkkkeiketqkkiienrdsi.iekeqqikeieekiknlnyekerlkeaiaesesiikhlkesemeiadeiaknqnelyrlkkelndldnlinrknf..............eieknnemi..kklkeeletvedvdtkplylelenlnveie......fskrgikeleekkkelqakldelh...aeyvkenarikalkemeelsmdraire...........ilnanlpgiidivgnlgkt...kieyktaievaagnrlnhivvkrmddavraikylkerkl.gratflpldriegreayyi.........dedgvigr.aidlvef.dekyrrvfeyvfgntvvvenidiakelakkyr....kvrfvtld..gdviepsgamiggtfk..................skakikvdvdlsklnkiadeiiaieselrkikeeierlskivkrssakkmeientleiikknemrkreiaekntikikelelknkdil....eeleelnlkr.eeilnrineies.kinelierrekiinelkeyesdenlkrmneiegelkilekekaklkneidkgltlvkeilipkieelnk...kvselinkkvil.....eknisfykesieknlsileekrkryeelaknlkeltekkeqlekeietlererr.......eilrkvrdienrinelmvekakye.skleeeerklylcekvdvs.kele.........................kkdieel.......................................................................................eiyigeleneiksl.epvnmraiedynyvaerykeliekrkeyerdekkylqlmeelenkkkevfmevfnkvaknfeevykei...........gg..igklslen...ekn.............................pfeggilidasprgkkllsldAMSGGEKSLTALAFLFA.....IQRLNPSPFYVLDEVDAALDVKNVSLIADMIK..NASKD.SQFIVISHREQMVSKA....DVVYGVYM.ENGLSK
O59462_PYRHO/3-1151              YIERLELKGFKSYGNKKVVILFSRGFTAIVGANGSGKSNIGDAILFVLGGL.SAKAMRASRISDLIFAG.............SKREPPAKYAEVTIYF........NNEDRG.......FPIDEDE..VIIKRRVYPDGR...SHYWL........NGRRATR.SEILDLLSAAMISPEg.yniilqgditkfikmsplerr.......liiddisgiaeydakkeralqelkqaeenlakvdili.gevkkqldklekerndalryldlkeklekarvglvlgeirkieseirnnderign..............iereiermekrleeiakeivekenelrrieemieressse..alrltreige.vnskinlarrnieiarreldesqlrlakvkdelkkvmseiekskga...............iirwgrrrealikqisekeeernhlvvrlgeidrtfavareefdsvvkelenarrlmyegeaeikrldaekeklrsriavlkakl..pgirdeilklrd.tldekkaelseienkls......svsnkrmkveeevekktlelqkvs...keledaerelirieaqnetksnravee...........lkrsgipgiygtllelirv..rdekysiavevalgnradnvvvedeivaekaieflkrnkl.grltflplnkikar..............hvngdvgipvvsviey.dpkienavsfalgdtvivssmeearsyig.......kvrmvtlk..gelyersgaitgghyrprgllldt..........kelkekvenlrimkeslegevnslrvklkalenqsfelrirmsdvekeisliskdleklikeeeslrseiedserkiaeid...........etiskkkdev.aklkgrierlek.rrdklkkalenpearevtekirevereiaklreelsrvegkleslnsrlndeliprk.......aslee...eieglvnkinal.....kanineneealksltekleklkkeegeiysrieeqkkkkeelerkvaelreeke.......kisrriqelrievntlkvrnsqlk.sllmeknsqlkhfskevik.sird.........................ipsdlegl......................................................................................kkeiekmeeeikal.epvnmkaiedfevverrylelkskrerleaekdsiiefineiekekknvfmktfdaiaknfselfarlsp.........gg..sarlilen...pdd.............................pfsggleieakpagkdvkrieAMSGGEKALTALAFIFA.....IQKFKPAPFYLFDEIDAHLDDANVKRVADLIK..ESSKE.SQFIVITLRDVMMANA....EKIIGVSM.RDGVSK
O66878_AQUAE/6-1140              YIEKIVVEGFKSYGTKRKEIPLGEGFIAVVGPNGAGKSNIGDAISFALGLS.SAKALRAKNLSYLIFS...............KNGQKADHAYVEVHF........KNLGA........FPVEDEE..VVISRKVSKDGR...SIFKI........NGQVVRE.RDLKDFLAKAGIYETa.ynvvyqgdivkflkmtpverr.......kiieeisgigeyerkkekaleelaevelkikeidlil.eeisnqlkrlkeekeklekfkelqrikreteakillkekekllkererilnelss..............lresleditfqiqenekelnererllkevnek..........impfkekvgk.ftaeienaersikekerelkesenrvknleelinnllsdkenlere....vgtlqleleklkeeykslkevereklreleeeeerlkitfdev........kkleeekeklteklnslnkekq..........eleiqranlknki..erikedinklis.ereekikeikekeqeik......rlkaikkkeeeelrnltqelniye...krlsevrkkleevlkekgaierevrsfsdvs.......dvfkdikgvygsvselirv..knpehitaievagggrlkfivvedeevakeciqlakrmnl.grfsfiplnrvrveerplryp.......rtkgavdf.avnlvey.dpkfekvvkfvfgdtlivenfesakaigig......nyrmvtle..gelfeksgvitggavkpsgelnk...........ryyeeelqrlnaeeeklkneesiiqkkireirnlisektallkvserkieelss..egleqyeekfkeklenskeylkile...........ekllnvedkl.kelaeeieyyee.klnnlklkegdikrhysregveekrreyskvrkqvseiekslneierelnkktyele........ylek...eiqekerereyl.....terikslkkeienlilfkektlqevkeaevkvydyikqkeelekeilnlksklg.......klkikeeelkekifekeknlkvle.ekienlneelkeyedlklg.adee.........................sipkl.........................................................................................keklkrvteeiqkl.gsvnfraeedyaeelkrfndykekqqklkeeskaikklieetenkkrkvfleafnqinkslkrifsflsp.........gg..kaqmfldn...ped.............................pfsggvqltvkprgkdvqyleAMSGGEKTLAALSLIFA.....LQEYKPSPFYYFDEVDAHLDEVNAKKVGELIR..EKSKE.AQFIVVTLREVVTSFA....DKIVGVSA.RGGISE
P73340_SYNY3/3-1194              YVKRIELSHFKSFG.GTTAIPFLPGFTVVSGPNGSGKSNILDALLFCLGLA.TSKGMRAERLPDLVNNT.............FKGNRGSSEASVSVTFELHDGENLSEPGANHNGNGNGAKISKEW..TVTRRLKVTKGGNYSSNYYI........NGETATV.TELHEQLNELRIYPEg.ynivlqgdvtriitmnskerr.......eiidelagvaefdrkivktketltevqdreercqiia.telertlerlaadrqkaekyqalrqqvqekqgwakviqykaveqqrqklwgqler..............dreqsqqiqqaldqrsqaiqtqqteleklnaqvkalgeee..qlavaaqlat.qkaqrdqlqqryndgdrqitnhqqqvgqiqaeisqsqqqflhiqqeksfhntqtlpqleaavqtsqqqleqlrhqaqaiasaseawvqeqtqlsrtvnqlqdelipqrsqlaqleerqqqllt..............nlaeltpll..tkvsveleekqf.aqgqfnfqgealtsqiq......tlasdlaqleqersllqetqtrll...keqqekqrqldkleaasqaqqevqgtyatkv.......ilqsdlpgvcglvaqlgqv...epqyqlaleiaaggrlgflvveddgvaaagieilkqaka.gratflplnkirppkgqnpnls......yahgyidl.avnlidg.drryadifafifgntivfdtlvnarnhlg.......khrivtle..gdlleasgamsggsrnqrsglrfgtmvsedtaevkqlrqrlqdiqqvqgrneelllertvrsrqltqqlmemrqqqreaqlhgeqterdiarlsqqqtqinqqqinqqqklaelq...........qnlallqqsl.ppleqqlasaqq.qltaletsqthqqwqtiqiqirtveaeyqrqlqalrqgedhlkdlqnssqrleekia........qaqe...kiaqhqaqdltl.....aqeqeqlkialaemngaiqtteaqlaklseklgstkqerdrletqlnqlrsqqqeqqwqweklqtnqqeyqenltqlqtqleale.qdlpdpwpeipllqdrdea.nldf.........................anileel.......................................................................................ersirngqkrleam.epvnmlalqeyektearlgelseklqtiagertelllrienfttlrrrsfqdafdavnknfqiifaelsd.........g...dgylqldd...aed.............................pfngglnlvahpkgkpvrrlsSMSGGEKSLTALSFIFA.....LQRYRPSPFYGFDEVDMFLDGANVEKLSKMVR..KQAQQ.AQFIVVSLRRPMIEAA....ERTIGVTQARGAHTQ
O51074_BORBU/6-815               VLKKIVLLGFKSFL.NRQEFEIGENLSFIVGPNGCGKSNLIDAVRFCMGED.NLKFLRVEDISDLISV...............SKSGKSNFAEITLFF........SNINSE......KSTLKEFNEDFYIRRRLYKDGS...SEYYF........NNKILNF.QDYNRLLNSFKFKKSp.ymfitqgrvedislernvnlk.......slieqasgidilkmeeeealknfkqssqnlssllslq.enlrqkydniknvfllrkkhqdlsqklealektitlkklfninfdlnvlkseln.........................................................ldglskflssgfkeklefysfreknvinniqelekdlelmkskilgleikiqkleqe......................................................................................................ktlkmnledkfvkskseseekknsinnnly......qlnsllkekkndffslsdeinryt...................................................ksffelvdl................................ilsvlrsaks...eefvllkeh..........................ildslkl.....................feeslsikyikeirvnlikyiskd..enll..............................allrdkiepifdqnvnlkkflleknalksnlakeitnierlieektlqlndvlgeleyielskfknl.........................deiklidgnl.eflfesknslde...........................elkdlylklenlnleksdiqlnlsnligask................................fssesfkekdfnslvflndfkktnyyeyikkqteyefllnsnv..................sikseienf..nvsnemsdkfele.edla...........................................................................................................................................trellrkeidaiklgdyvffnidkefdetkerfekvslqvedlklskyslqklqkkikneiykkfresfdeinknfsfffkkifk.........g...taslfyne...ntd.................................nveirinfsnkfvknnnMLSGGESTLVSMAFLFA.....LYYYSPACFCMLDEIDAALDFENSKKLSLLLR..ELGKK.FQLLVITHNAYVSEGG....ENLIGITL.DNGESR
SMC2_YEAST/2-1166                KVEELIIDGFKSYATRTVITDWDPQFNAITGLNGSGKSNILDAICFVLGIA.SMSTVRASSLQDLIY...............KRGQAGVTKASVTIVF........DNTDKS...NSPIGFTNSPQ..ISVTRQVVLGGT...SKYLI........NGHRAPQ.QSVLQLFQSVQLNINnpnflimqgkitkvlnmkpseil.......slieeaagtkmfedrrekaertmskketklqenrtllteeiepkleklrnekrmflefqstqtdlekterivvsyeyynikhkhtsiretlen..............getrmkmlnefvkktseeidslnedveeiklqkekelhkegtisklenkeng.llneisrlktslsikvenlndttekskaleseiasssakliekksa...........yantekdykmvqeqlskqrdlykrkeelvstlttgisstgaad.ggynaqlakaktelnevslaik..........kssmkmellkkel..ltiepklkeatk.dnelnvkhvkqcqetcd......klrarlveygfdpsri...........kdlkqredklkshyyqtcknseylkrrvtnlefnytkpypnfeasfvhgvvgqlfqidndniryatalqtcaggrlfnvvvqdsqtatq...llergrlrkrvtiipldkiytrpissqvldl.akkiapgkvel..ainlirf.desitkamefifgnslicedpetakkitfhpki...rarsitlq..gdvydpegtlsggsrntsesllvdiqky......nqiqkqietiqadlnhvteelqtqyatsqktktiqsdlnlslhkldlakrnldanpssqiiarneeilrdigeceneiktkqmslkkcqeevstiekdmkeydsdkgsklnelkk.elkllakeleeq............eseserkydlfqnleleteqlsseldsnktllh..................nhlksiesl.....klensdlegkirgveddlvtvqtelneekkrlmdiddelneletlikkkqdekk.......sselelqklvhdlnkyksntnnme.kiiedlrqkhefledfdlv.rniv.........................kqnegidldty...................................................................................rerskqlnekfqelrkkvnpnimnmienvekkeaalktmiktiekdkmkiqetisklneykretlvktwekvtldfgnifadllp.........ns..faklvpce...gkd..............................vtqglevkvklgniwkesliELSGGQRSLIALSLIMA.....LLQFRPAPMYILDEVDAALDLSHTQNIGHLIK..TRFKG.SQFIVVSLKEGMFANA....NRVFRTRF.QDGTSV
SMC2_CHICK/2-1167                YIKSIVLEGFKSYAQRTEIRDFDPLFNAITGLNGSGKSNILDSICFLLGIS.NLSQVRASSLQDLVY...............KNGQAGVNKATVSITF........DNSDKK...NSPLGFENNDE..ITITRQVIVGGR...NKYLI........NGMNASN.NRVQDLFGSVGLNVNnphflimqgqitkvlnmkpteil.......amieeaagtrmyeckkitahktiekkeskldeirriiteeisptleklkearasyleyqkmtrevenlrriyvafqyvraeeikdrstnalke..............aqankkkifesmaenekkvkelaqqieetekknneefgak..lhsleaafse.lqrvdakvrsdldhrkqnlnseenrlkelikimqeefkaftskeke...........ikkikeglnglqeeskkdaealasaqqhfnavsaglssndsgqgtsladqmmtckneiskaateak..........qaqmklkyaqqel..ktkqaevkkmdg.sykedqeafeairktke......klqdemkklkyeeaeqeahlakk....kqlsseisslrelcesieakhpylrfeyknp.......eknwnpncvkglvvtlitv..kdistskaleavaggklynivvdteatgkk...ilekgqlkhrytiiplskisansigheiisl.aknlighrevhi.aislidy.nselqkameyvfgttlvcssmdnakkvtfdkri...mrktvtlq..gdifdpqgtlsggasshvtpilsklktm......rdaedelkiktsqleatekelanlknmaekyqhlkqqwemkseeaellqtkiqqsayhkqqedllalkktiaeceetlkkteesqrkaeeeykalenkmknaeaergkeiknaqq.klnsakkkadds............srkmkekqqevealvleleqlkqeqasykqqse..................aaqqaiasl.....keqvsaleaeavktreslknaenelssekglmeertkdikaksakiekyreqnn.......elqlsinalehdinkyqqetadas.stldkllkeykwiasekel.fgqa.........................dttydfeannpket................................................................................gqklqklltkkeklekslnmramnllseaeeryndlmkkkrmvendkikilatieeldrkknkalhiawekvnkdfgsifsmllp.........ga..kamlvpsk...kqn..............................ildglefrvglgdiwkenltELSGGQRSLAALSLILA.....ILLFKPAPIYILDEVDAALDLSHTQNIGQMLH..AHFKQ.SQFLVVSLKDGMFNNA....NVLYRTKF.VDGIST
SUDA_EMENI/2-1193                YVKQIIIQGFKSYKDQTVIEPFSPKHNVIVGRNGSGKSNFFAAIRFVLSD..AYTHLGREERQALLHE...............GSGSAVMSAYVEIIF........DNSDER.......FPTGKPE..LVLRRTIGLKKD....EYTL........DRKNATK.NDVMNLLESAGFSRSnpyyivpqgrvtaltnmkdserl.......nllkevagtqvyearraeslkimhetnskrekidell.dfinerlaeleeekdelrnfqekdkerrcleytiysreqqeiasfldsleeqrqtgvedt...dinfiqgekemaqvdaeiaeckqqieflkvdkaqlederrea.ska..laqvelqaks.lsdnqaaaqeskarhdeslkavqsaieerqtelkelvprfisakda.....edaaraklteaetarqrlyakqgrnsrfknkserdkwlqaeiknnnasi.ssvqsvlsqtqedindiendia..........llepeterlrqidgrgdtiqsveqqvq.aakderdrlmdqrkyvdwprtscatltihrelwreeakldsilinas...nevdraernlsqmmdhntsrgiaavrri..........krqhnlegvygtlaelfev...ndryrtavevtagqslfhyvvdtddtatkvleilqheka.grvtfmplnrlrtkpln.....m.pkasdtip.....mieklqy.drayekafqhvfgktiicpnlqvasqyarsh.....gvnattpe..gdrsdkrgaltggfhds.rqsrldavknl.....akwrdeyetkksrgseirkeleeldqlitravgelqkleqqrhqvqnssgplrqelrskrdllqkqndnldakrralrniegnlaalk....dqvdafeaelsspfhkaltdeeearleslnsnvqey............rreyqelsgkrseletrksvlevelrenlnprl..............dqllaqdadi...adedgqgniketqreqkrltkvldklaqrlaqvdesmeqansrvteltqrnaesrrele.......elaksiekhqrrmeksmqkkaalt.kqaaecaanirdlgvlpde.aft..........................kykntdsntv....................................................................................vkklhkvnealkky.ahvnkkafeqynnftkqretltsrreeldasqksiddlisvldhrkdeaiertfkqvsrefatifeklvp.........ag..rgrliiqr...ktdrtqraeddles.......edeeakhsvenyvgvgisvsfnskhddqqriqQLSGGQKSLCALALVFA.....IQACDPAPFYLFDEIDANLDAQYRTAVAQMLKTISDSTN.GQFICTTFRPEMLHVA....EKCYGVSF.RQKAST
Q24098_DROME/33-1211             HIKQIIIQGFKSYKDQTVVEPFDKRHNVVVGRNGSGKSNFFYAIQFVLSD..EFTHLRPEQRQSLLHE...............GTGARVISAYVEIIF........DNSDNR.......VPIDKEE..IFLRRVIGAKKD....QYFL........NKKVVPR.NEVVNLLESAGFSSSnpyyivkqgkinqmataadsyrl.......kllrevagtrvyderkeeslnllretdskvekiseyl.ktiedrlqtleeekeelkeyqkwdktrrtleyiryetelkdtkkaldelqlqrksssdkkkiynieiqkaqekikdvqknlkeakkkvqstkeersvlmteqqql.lre..ktkldltivd.lndevqgdnkskeradqelknlkvtiaerekelddvkpkyeamkrk.....eedcsrelqlkeqkrkelyakqgrgsqfssredrdkwitnelksiskqtrdkiahhaklvedlkkdatsekd..................lgqki..eehsseleqlrl.qidehnkkyyelkktkd......qhqsmrnelwrketqmtqqlqthk...eelsradqalrsmagkpilngcdsvrkvldsfverg.gqsaeiarayygpvienfsc...dktiytavevtaanrlfhhiveseyegtqilkemnklklpgevtfmplnrlqvkihd.....y.pddpdsip.....misklky.deqhdkalryifgktlicrnleratelakst.....gldcvtld..gdqvsskgsltggyfnt.srsrlemqkkr.....teytsqiaefekklsklrnelkstenninsivsemqktetkqgkskdvfekvqgeirlmkeelvrieqyrapkerslaqckaslesmt....stkssleaelkqelmstlssqdqreidqlnddirrl............nqenkeaftqrmqfevrknkldnllinnlfrrr..............deliqalqei...svedrkrklnncktelvsaekrikkvnsdleeiekrvmeavqlqkelqqelethvrkek.......eaeenlnkdskqlekwstkenmln.ekidectekiaslgavplv.dps...........................ytrmslkni....................................................................................fkelekanqhlkky.nhvnkkaldqflsfseqkeklyrrkeeldigdqkihmliqslemqkveaiqftfrqvaqnftkvfkklvp.........mg..agflilkt...kdnegdemek...............evensdaftgigirvsftgveaemremnQLSGGQKSLVALALIFS.....IQKCDPAPFYLFDEIDQALDAMHRKAVANMIH..ELSDT.AQFITTTFRPELLENA....HKFYGVRF.RNKVSH
SMC3_YEAST/2-1208                YIKRVIIKGFKTYRNETIIDNFSPHQNVIIGSNGSGKSNFFAAIRFVLSD..DYSNLKREERQGLIHQ...............GSGGSVMSASVEIVF........HDPDHSMILPSGVLSRGDDE..VTIRRTVGLKKD....DYQL........NDRNVTK.GDIVRMLETAGFSMNnpynivpqgkivaltnakdkerl.......qlledvvgaksfevklkaslkkmeeteqkkiqinkem.gelnsklsemeqerkelekynelernrkiyqftlydrelnevinqmerldgdynntvysseqyiqeldkredmidqvskklssieaslkiknatdlqqaklreseisqk..ltnvnvkikd.vqqqiesneeqrnldsatlkeiksiieqrkqklskilpryqeltke.....eamyklqlaslqqkqrdlilkkgeyarfkskderdtwihseieelkssi.qnlnelesqlqmdrtslrkqys..........aideeieelidsingpdtkgqledfds........elihlkqkls......esldtrkelwrkeqklqtvletll...sdvnqnqrnvnetmsrslangiinvkeite........klkispesvfgtlgelikv...ndkyktcaeviggnslfhivvdteetatlimnelyrmkg.grvtfiplnrlsldsdvkfpsnt.ttqiqftp.....likkiky.eprfekavkhvfgktivvkdlgqglklakkh.....klnaitld..gdradkrgvltggyldqhkrtrleslknl.....nesrsqhkkileeldfvrnelndidtkidqvngnirkvsndresvltnievyrtslntkkneklileeslnaiilkleklntnrtfaq....eklntfendllqefdselskeekerlesltkeisaa............hnklnitsdalegitttidslnaelesklipqe..............ndleskmsevgdafifglqdelkelqlekesvekqhenavlelgtvqreiesliaeetnnkkllekannqqr.......lllkkldnfqksvektmikkttlv.trreelqqrireigllped.alvn.........................dfsditsdql....................................................................................lqrlndmnteisgl.knvnkrafenfkkfnerrkdlaeraseldeskdsiqdlivklkqqkvnavdstfqkvsenfeavferlvp.........rg..takliihr...kndnandhdesidvdmdaesnesqngkdseimytgvsisvsfnskqneqlhveQLSGGQKTVCAIALILA.....IQMVDPASFYLFDEIDAALDKQYRTAVATLLK..ELSKN.AQFICTTFRTDMLQVA....DKFFRVKY.ENKIST
SMC4_YEAST/155-1406              FINELVLENFKSYAGKQVVGPFHTSFSAVVGPNGSGKSNVIDSMLFVFGFR.AN.KMRQDRLSDLIHK..............SEAFPSLQSCSVAVHF....QYVIDESSGT.......SRIDEEKPGLIITRKAFKNNS...SKYYI........NEKESSY.TEVTKLLKNEGIDLDhkrflilqgeveniaqmkpkaekesddglleylediigtanykplieermgqienlnevclekenrf.eivdreknslesgketaleflekekqltllrsklfqfkllqsnsklastlekiss..............snkdledekmkfqeslkkvdeikaqrkeikdrissc.ssk..ektlvlerre.legtrvsleertknlvskmekaektlkstkhsiseaenmleelrgq....qteheteikdltqllekersilddiklslkdktknisaeiirhekelepwdlqlqekesqiqlaeselsllee..............tqaklkknv..etleekilakkt.hkqelqdlildlkkkln......slkdersqgeknftsahlklkemq...kvlnahrqramearsslskaqnkskvltalsrl.....qksgringfhgrlgdlgvi...ddsfdvaistacp.rlddvvvdtvecaqhcidylrknkl.gyarfilldrlr..qfnlqpist.penvpr.......lfdlvkpknpkfsnafysvlrdtlvaqnlkqannvaygkk....rfrvvtvd..gklidisgtmsgggnhv.akglmklgtnqsdkvddytpeevdkierelserennfrvasdtvhemeeelkklrdhepdlesqiskaemeadslaseltlaeqqvkeaemayvkavsdkaqlnvvm.knlerlrgey.ndlqsetktkke.kikglqdeimkiggiklqmq....nskvesvcqkldilvaklkkvksaskksggdvv........kfqk...llqnserdvels.....sdelkvieeqlkhtklalaendtnmnetlnlkvelkeqseqlkeqmedmeesin.......efksieiemknkleklnslltyik.seitqqekglnelsirdvt.htlg.........................mlddnkmdsvkedvknnqeldqeyrscetqdeseikdaetscdnyhpmnidetsdevsrgiprlsedelreldveli.................eskinelsyyveet..nvdigvleeyarrlaefkrrkldlnnavqkrdevkeqlgilkkkrfdefmagfniismtlkemyqmitm.........gg..naelelvd...sld.............................pfsegvtfsvmppkkswrnitNLSGGEKTLSSLALVFA.....LHKYKPTPLYVMDEIDAALDFRNVSIVANYIK..ERTKN.AQFIVISLRNNMFELA....QQLVGVYKRDNRTKS
SMC4_SCHPO/125-1313              VVYELRLTNFKSYAGTQIVGPFHPSFSSIVGPNGSGKSNVIDALLFVFGFR.AS.KLRQSKASALIHK..............SATHPSLDSCDVEITF........KEVNSD......FTYVDGSE..LTVRRTAYKNNT...SKYFV........NGVESSF.SAVSNLLKEKGIDLNhkrflilqgevesiaqmkpraisegddglleylediigtskykpiieenmqelsnsddicaekesrl.klvlsekakledsknsvlsflkdenelfmkqnqlyrtilyetrnkktlvqnllns..............legklqahlekfeqterdisekneevkslrekaakv.knd..ctsekktrqs.yeqqtvkieeqlkfllnkekklkksiealsfekseaenslsshdid....sqklnseiadlslrlqqeelslddirkslqgktegisnaieekqkamapalekinqltsekqilqveldmlln..............kendlindv..essqssldklrn.daeenrnilssklkvls......dlkgekkdvsknierkketvhnty...rnlmsnrtkleemkaslsssrsrgnvleslqrl.....hesdnlngffgrlgdlati...deaydvaistacp.alnhivvdnietgqkcvaflrsnnl.grasfiilkela..qknlariqt.penvpr.......lfdllrfndqkfapafynvlqntlvaknleqanriaygkt....rwrvvtls..gqlidksgtmtgggtrvkkggmssaits......dvspasvetcdkqvqledtryrqhlseleslnqrfteiseripsaeleisklqldvsacdrlvageerrilqlksdlksirnnnerkrnlq.nkisnmdkev.eaininneglvt.eiktlqdkimeiggiryriq....kskvddlheqlkfvkdklnkmsfkkkkneqrsq........sfqv...elsnltseydtt.....tesiatlktelqslnkyvdehksrlrefenalwdinssidelvkfiefeskqmn.......svkaerielenqiqeqrtalsevg.nnenkylklmsnlklhnlt.efcd.........................qttmds.....................................................tfpeysedelssvdksel.................vsnisvlkkktedr..evdinvlseyrrcnkeaekrdsdyqselqkrtdlkkvvtdlqsqrldefmygfgiismklkemyqiitm.........gg..naelelvd...sld.............................pfsegvlfsvmppkkswknisNLSGGEKTLSSLALVFA.....LHNYKPTPLYVMDEIDAALDFKNVSIVANYIK..ERTKN.AQFIVISLRSNMFELS....SRLVGIYKTANMTKS
SMC4_XENLA/77-1268               MITHIVNQNFKSYAGERILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYR.AQ.KIRSKKLSVLIHN..............SDEHKDVQSCTVEVHF....QKIIDKEGDD......FEVIPNSN..FYVSRTAYKDNS...SVYHI........SGKKATF.KDVGLLLRSHGIDLDhnrflilqgeveqiammkpkgqtehdegmleylediigserlkepiqilcrrvellneqrgeklnrv.kmvekekdalegeknkaiefltvenetfkkknqlcqyyihdlqkrsrdkeaqkek..............iqedtkdiseksntlletmkeknkalkdvekqlnki.tkf..ieenrekftq.ldlqdvdtreklkhskskvkklqkqlqkdkekvdelknvpansqki....iaeetnkkdllekqkekeeeklknvmdslkketqglqeekevkekelmeisktvnearskmdvaqseldiyls..............rhnsalsql..nkakealntasa.tlkerraaikeletklp......kdegdlkkrekeleslvseegnik...nqvrelrqkveearsslsanrsrgkvldaliqq.....kksgkipgifgrlgdlgai...dekydvaissscg.aldhivvdtidtaqecvnflkkqnv.gvatfigldkmkvwekglnkiqt.penipr.......lfdmvkvkdeqikpafyfalrdtivannldqatrvafqkdk...rwrvvtlq..gqiieqsgtmtggggkvmkgrmgssvmv......eisddqlqkmenklktdttrateiqdrkahleeevaklrqatremkntfekytaslqslseqevhlkaqvkelevnvaaaapdknqqkqme.knletlkkey.ekvaekagkvea.evkrlhklivdinnhklkaq....qdkldkvtkeidecasaitkaqvsiktadrnlk........ksee...avartekeivan.....dksieeltedlkkleekattvmneckeaecslpevqeqhrsllqeikaiqekeh.......alqkealnirlnieqidshiaehq.skikywqkeitkislhkie.dipe.........................e..........................................................vlpglaqeeleaikdpdqi................inqialleakshem..kpnlgaiaeykkkeelylqrvaeldeitnerdsfrrayedlrkqrlnefmagfniitnklkenyqmltl.........gg..daelelvd...sld.............................pfsegimfsvrppkkswkkifNLSGGEKTLSSLALVFA.....LHHYKPTPLYFMDEIDAALDFKNVSIVAFYIY..EQTKN.AQFIIISLRNNMFEIA....DRLIGIYKTHNTTKS
DPY27_CAEEL/92-1330              IILNIYVENFKSYAGKHILGPFHKNLTMILGPNGSGKSNVIDALLFVFGFK.AG.KIRTKKLSALI.................NSGGNYESCSVTIMFQMVKDMPVENYDKY.......EVLTDNC..VCITRTINRENN...SKYRI........DDKDASQ.KDVQELLLRAGIDMThnrflilqgeveaialmkptsknpneegmleyiedivgtnrfvapisklmhrvsllehkssqygasv.rrheghlkvfekamvigmaylntfnnlnylrgirvkhnlcryaetmrdakmslvt..............rtgeleenkdimleakdevrkketherslnsivtel.enk..ridwqskknd.whardakrkqglksctqdlgklmkerdearrekfeietapenaris....kqnmqlewdqlkeqenvcqrtatenlikydqkssadrakhddlekklsdellqsmrakaeldvseselkdmti..............mmeqgqkrv..delkgtlqtmma.enirdntelnavttelq......drklkfdkaveklphlksteqllrskkyeldqevieasntqevtyrhqataklhel.........keaglfpgfkgrlgdlasi...pikfdtaistvffaqldyhvvqtsdecrigigfcheykl.prttfvfldhlkdtdtsgmdstm.kfpaer.......lfdkihcvnpeirrefyflihdilvvdsleeatridkkypg...rhryctln..gsilnrsgaltgggkpttgrirndnnpnm....sgvkkvdlsklraaqekhnhaleahlklqlkqeeiradngpiikqleirkrelimstkeqktriaelkssiaaherrmvnyrevtvedldekraqiadlkrqv.eesqkssakikq.qieqykrkmdrmfmelvqkn....kdsieqakdrmgqleqdiarqtaiiennpshle.qaekklselehmclekrseadalaqlevgedvkgidiinaqlqtstasidaqraryteavaarreadaayqttvdnynmvkqtyd.......elmriiddlenktmadnaeldiie.sawmqpeklyppgkfvryn.dpdi.........................aakmtdghvvlpyeci...........................................smiephreayeehearmleddvfedt.........ankicklekdvdkfrrefdnkgvrdyamivsllmnevtsakkfsdklkahreklnelrmarfnefsealaflgtttqmlyqlitn.........gg..daslkfveegkstd.............................pfdggikfsvrpakkswklieNLSGGEKTLASLCFVFA.....MHHYRPTPLYVMDEIDAALDLNNVSLIANYIKHSERTRN.AQFIIISLRNQMFEVG....NRLLGIYKIDGKTYN
SMC4_CAEEL/91-1361               MIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFR.AS.KIRSAKVSNLIHK...............SAGRNPDKCTVTIHF....QRIVDIPGHY.......EVVKDSE..FTISRTAFQNNS...SSYAI........DGRPATK.NEVEARLRRVDIDIEhnrflilqgeveqiammkpvkttksetgmveylediigtnrlepfvklfqrrvnrltcdlsqqriar.dharnskvamenpvraaieflmkeneattihmkleqrrrqryldkiapkqaeldk..............mkeemksiaetldtnkneykqseeaqkvmieerskl.dkn..fdslskelsd.lgteetrrkealkrhqaniskaeaekekevkkrsnleaapekaerk....iakcqeeveqlleiektaneeadknldefekrseapkeeqkkiqetwaqksnefnkvrgeariaredfedlkk..............lansgtdkl..ielkkrlessee.syakekdeldklkpefd......swndklkqlstelptlrntarqkn...qdlaktrdrletlrqqnsscsssnkviqalmke.....keagriksfhgrlgdlgvi...dpkyegaictnfgarlnylivgkeedaknvinflvankl.prqtvqpldkikcdkrdlapnptnplpapr.......lidlidc.dpvlkpafydmvrsaivgdstqeaqrmhrmpacr..gvtvctle..gsmihpsgsftgggktvkgliltdknkmakq.vtpedkaaerdlaeklgklrdeadelkgqehemdgqliearrkvaemsnrlsivtssvqsaapaietlkktianqekeaakvkvdaktledkq.kiveelekkr.delgeeaakvka.rqaeiqskldgifkelvqch....rdeakeslqkrqklekdiaketanisnsgrnia.kcdenisrhdkdiekmkkkceelmekaid..deevkskketverfekqikklqtkgeemtkkqselsaaetklegelkkcsegik.......elkesmladrlkvediekklaalkvnriprfqfliessrpedlemqidd.........................kmpvvdenqspeeverqkkhmacvmsdaayalefemrqkvlentesyenvdgedrvpvellsdekineissrdaeem.................qmklkvceqqvealkakvdissikayvdkvkqyneqvikltiatevhrkhnqelqrikqmrleefhsafefigkhlvavfkmltd.........gg..dakleyid...kdd.............................pfrqgisfmvrpakkawkqiqFLSGGEKTLSSLALIFA.....LHMFRPTPFYVMDEIDAALDYRNVSIIAQYVR..QKTEN.AQFIIISLRNNMFELA....NRLVGIYKVDGCTRN
SMC1A_HUMAN/3-1212               FLKLIEIENFKSYKGRQIIGPFQR.FTAIIGPNGSGKSNLMDAISFVLGEK.TS.NLRVKTLRDLIHGA.............PVGKPAANRAFVSMVY........SEEGAE................DRTFARVIVGGS...SEYKI........NNKVVQL.HEYSEELEKLGILIKarnflvfqgavesiamknpkert.......alfeeisrsgelaqeydkrkkemvkaeedtqfnyhrk.kniaaerkeakqekeeadryqrlkdevvraqvqlqlfklyhneveieklnkelas..............knkeiekdkkrmdkvedelkekkkelgkmmreqqqi.eke..ikekdselnq.krpqyikakentshkikkleaakkslqnaqkhykkrkgdmdeleke...............mlsvekarqefeermeeesqsqgrdltleenqvkkyhrlkeeaskraatlaqelekfnrdqk..........adqdrldleerkk..veteakikqklr.eieenqkriekleeyit......tskqsleeqkklegelteevemakrrideinkelnqvmeqlgdaridrqessrqqrkaeime..sikrlypgsvygrlidlcqp..tqkkyqiavtkvlgknmdaiivdsektgrdciqyikeqrg.epetflpldylevkptdeklrelkgakl.........vidviryepphikkalqyacgnalvcdnvedarriafgghq...rhktvald..gtlfqksgvisggasdlkakar............rwdekavdklkekkerlteelkeqmkakrk.eaelrqvqsqahglqmrlkysqsdleqtktrhlalnlqekskleselanfgprindik...riiqsrerem.kdlkekmnqvedevfeefcreigvrnirefeeek...vkrqneiakkrlefenqktrlgiqldfeknqlk....edqdkvhmweqtvkkdeneiekl.....kkeeqrhmkiidetmaqlqdlknqhlakksevndknhemeeirkklggankemt.......hlqkevtaietkleqkrsdrhnll.qackmqdiklplskgtmddisqee.........................gssqgedsvsgsqrissiyarealie.................................idygdlcedlkdaqaeeeikqemntl.........qqklneqqsvlqri.aapnmkameklesvrdkfqetsdefeaarkrakkakqafeqikkerfdrfnacfesvatnideiykalsr.........nssaqaflgpen...pee.............................pyldginyncvapgkrfrpmdNLSGGEKTVAALALLFA.....IHSYKPAPFFVLDEIDAALDNTNIGKVANYIK..EQSTCNFQAIVISLKEEFYTKA....ESLIGVYPEQGDCVI
O01789_CAEEL/15-1251             TLHTLEIENFKSYKGKHTIGPFTR.FTAIIGPNGSGKSNLMDAISFVLGEK.PS.SLRVRKYADLIHGA.............PINKPVAKKCRVTMNY........KYSDGK................VKAFTRGVNNGT...SEHLL........DGQTVTS.AAYSQEMESINIFIKarnflvyqgaieniamktpkert.......qlfeelsrshefqaeyerlkvemtkaeddtqhnmnkr.rgiaqekreakmekdeaekyqtmknelaakstmlflhqlfhcertideskeeina..............qkktiasleatrskeeakiaavhqehrkalrevqkm.trk..ldqketdlae.kqqnmltlkvsvahehkkleiakkmlaaaeskaennstqladlkks...............kkelekkkaayeaeiqdmmqrge..lnlsdeqvreygqlkdqaqresamvqrellmaeqvfe..........gdksslnhelrrq..kehqervkakeg.dvrrietqiatlaqrik......eteeetkilkadlkkiendvvidksaaaeynkelvavvrqlseasgdsaegernqrrteale..glkknfpesvygrlvdlcqp..shkrfniattkilqkhmnsivcdteetaakaivylkdhry.ppetflpndalvvnplneklreikkpagvkl......vfdvinpqhqaarkalqfvcgnalvcesqedakqlaygggelkdrfkavsmd..gtlfqqsgvmsggsadlrqksk............kwdekvvkqlrekrnqlnekiadlqkhrrr.elevesvrskingneqrlammkrdlknmremqlerlqnelegmtaemnmlpprisncq...eklersestl.kslqtksnevadrifadfctrvgiasirdyenre...mrikqemedklrsfdddiqklayeidfvteqdg......nrkvevekekvsqidrqykdm.....kkkektaaaalkehtesmeqdkevleekkalshkletewnevkkiaqvamkdft.......kaekellrleslltkkqyerhsll.hsvklgqialplksgsmadveyeeddgdiyfiifvslfpfkfqlisddtasqssqsatdgpsvseeqiqreqhik.................................inydslpreykdvddddgvrqmsnrl.........nveidelqknvskm.napnlkanqrmaevkereaesteelenarkkakrirqqfekvktdryrrfqdffdpvantiddiykqlsr.........ntsaqaflgadn...mee.............................pyldgiqyncvapgkrfrpmdNLSGGEKTIAALALLFA.....VHGRNPAPFFVLDEIDAALDNTNIGKVASYIC..ESAREHMQIIVISLKEEFYNKA....DSLIGIFPYPAACTT
SMC1_YEAST/3-1212                RLVGLELSNFKSYRGVTKVGFGESNFTSIIGPNGSGKSNMMDAISFVLGVR.SN.HLRSNILKDLIYRGVLNDENSDDYDNEGAASSNPQSAYVKAFY........QKGNKL................VELMRIISRNGD...TSYKI........DGKTVSY.KDYSIFLENENILIKaknflvfqgdveqiaaqspvels.......rmfeevsgsiqykkeyeelkekieklsksatesiknr.rrihgelktykeginkneeyrkqldkknelqkfqalwqlyhleqqkeeltdklsa..............lnseisslkgkinnemkslqrskssfvkesaviskq.ksk..ldyifkdkek.lvsdlrlikvpqqaagkrishiekrieslqkdlqrqktyverfetq...............lkvvtrskeafeeeikqsarnydkfklnendlktynclhekylteggsileekiavlnndkr..........eiqeelerfnkra..diskrriteelsitgekldtqlndlrvsln......eknalhterlhelkklqsdiesannqeydlnfklretlvkiddlsanqretmkerklrenia...mlkrffpgvkglvhdlchp..kkekyglavstilgknfdsvivenltvaqeciaflkkqra.gtasfipldtietelptlslpds.qdyil........sinaidy.epeyekamqyvcgdsiicntlniakdlkwkkgi...rgklvtie..galihkaglmtggisgdann..............rwdkeeyqslmslkdklliqidelsngqrsnsirarevensvsllnsdianlrtqvtqqkrsldenrleikyhndliekeiqpkitelk...kklddlentk.dnlvkekealqnnifkeftskigftikeyenhsgelmrqqskelqqlqkqiltvenklqfetdrlsttqr........ryekaqkdlenaqvemksl.....eeqeyaiemkigsieskleehknhldelqkkfvtkqselnssediledmnsnlq.......vlkrerdgikediekfdlervtal.knckisninipissettid.dlpi.........................sstdneaitisnsid............................................inykglpkkykenntdsarkel.............eqkiheveeilnel..qpnaralerydeaegrfevinneteqlkaeekkilnqflkikkkrkelfektfdyvsdhldaiyreltknpnsnvelagg..nasltied...ede.............................pfnagikyhatpplkrfkdmeYLSGGEKTVAALALLFA.....INSYQPSPFFVLDEVDAALDITNVQRIAAYIR..RHRNPDLQFIVISLKNTMFEKS....DALVGVYR.QQQENS
#=GR SMC1_YEAST/3-1212     SS    -EEEEEEES-SS--SEEEEE-TT-SEEEEE-STTSSHHHHHHHHHHHTT--.--.-------TTSS------------------------EEEEEEEE........EETTEE................EEEEEEEETTS-...EEEEE........TTEEE-H.HHHHHHHHCTT--TTT-TTEE-TT-TTHHHHS-HHHHH.......HHHHHHHSTTTTHHHHHHHHHH---------------.------------------------------------------------TTHHHHH..............HHHHHHHHHHHHHHHHHHHHHHHHHHT---------.---..-EEEEEESSS.SSGGGS-EEEEEE-TT----SGGGS-HHHHHHHHHHHHHHHHTSS-...............-SEEEESSTTTT--HHHHHHHHHHHHHH-BTTBEEEEE-S-HHHHTT-XXXXXXXXXXXXXX..........XXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXX.XXXXX........XXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXX..XXXXXXXXXXXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX........XXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......XXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXX.XXXX.........................XXXXXXXXXXXXXXX............................................XXXXXXXXXXXXXXXXXXXXXX.............XXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXX...XXX.............................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXX....XXXXXXXX.XXXXXX
#=GC SS_cons                     -EEEEEEES-SS--SEEEEE-TT-SEEEEE-STTSSHHHHHHHHHHHTT--.--.-------TTSS------------------------EEEEEEEE........EETTEE................EEEEEEEETTS-...EEEEE........TTEEE-H.HHHHHHHHCTT--TTT-TTEE-TT-TTHHHHS-HHHHH.......HHHHHHHSTTTTHHHHHHHHHH---------------.------------------------------------------------TTHHHHH..............HHHHHHHHHHHHHHHHHHHHHHHHHHT---------.---..-EEEEEESSS.SSGGGS-EEEEEE-TT----SGGGS-HHHHHHHHHHHHHHHHTSS-...............-SEEEESSTTTT--HHHHHHHHHHHHHH-BTTBEEEEE-S-HHHHTT-XXXXXXXXXXXXXX..........XXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX......XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXX.XXXXX........XXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXX..XXXXXXXXXXXXXXXXXXXX..............XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX...XXXXXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX........XXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.......XXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXXXXXXXXXXXXX.XXXX.........................XXXXXXXXXXXXXXX............................................XXXXXXXXXXXXXXXXXXXXXX.............XXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXX...XXX.............................XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX.....XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXXXXXX....XXXXXXXX.XXXXXX
#=GC seq_cons                    hlcclhlpsFKSat.cplhhsFstsFssIlGPNGSGKSNllDAIhFVLG.p.supplRupphscLIat...............pstsssppApVplhF........sppspt..........t..p..hslpRphhpsGs...ScYhI........NGcsssh.p-ltcLLtptsIshps.h.ll.QGclpplhphpPppRp.......phlE-huGstcactchccuhpclpchppphpphp.hh.pplppphpphcpptpph.ca.phppphpthchhlh.hph.phtpphpphptplpp..............hppphpphptphpp.ppplpthppphpphtpphpp..ppp..h.thptphpp.hptpht.hcpphpth.pphpphppphtphppchpphptthtphctp...................p.....htt..tt.tpt.p.......t..p..t...tph.t..t.hp.....ht...t...............ht.htpph..tphptplpph.t.phpp.ppphtphppplp......phptthpphtpphtphptphp.hp...ppltp...th.th.......t...................t..h.uhhGhlhpLhph...p.paphAlpsshuttht.llVcs.psutpslphL+ppph.sphoFlsLsplt...ht....................hhshlch.c.phptsh.hhhtssllspshppApplshhh.....th+hVTLc..Gplhp.pGshoGG..p..t...............t..ppplpphppphpthppphpphptt.pphptphpphppthpphp.php.hptphpthppt..thptph.t.p.th.th............pplpphptph.pphtpphpphpp.phpphppphtt.............ppp.pphtpthpphptphpplp.phpp..tt.t................h.p..tph..h.....ppplpphcpcLpphppplpphcschpEhppth.phptphpph.p.htthppp.p.......plptphtphppplpp...tht.ht.pth......h...t.................................................................................................................................ppclpchppplpch.tplNhpuhccapchpcchpplspphcchcptcpsl.phhpclcpt+hc.F.tsFp.lspphptlap.Lh..........GG..pAcLplps...ss-..............................httGlphpspsstKphpplp.LSGGEKoLsALALlFA.....lpphcPsPhYlhDElDAALD.pNsptlAphl+..cpscp.uQFIVlol+pshhptA....-plhGlhh.csuhsp
//
