# STOCKHOLM 1.0
#=GF ID   RRM_1
#=GF AC   PF00076.13
#=GF DE   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
#=GF PI   rrm;
#=GF AU   Eddy SR, Birney E
#=GF SE   Published_alignment
#=GF GA   17.70 17.70; 17.80 17.80;
#=GF TC   17.70 17.70; 17.80 17.80;
#=GF NC   17.60 17.60; 17.70 17.70;
#=GF TP   Domain
#=GF BM   hmmbuild -F HMM_ls SEED
#=GF BM   hmmcalibrate --seed 0 HMM_ls
#=GF BM   hmmbuild -f -F HMM_fs SEED
#=GF BM   hmmcalibrate --seed 0 HMM_fs
#=GF AM   byscore
#=GF RN   [1]
#=GF RM   8290338
#=GF RT   Analysis of the RNA-recognition motif and RS and RGG
#=GF RT   domains: conservation in metazoan pre-mRNA splicing
#=GF RT   factors. 
#=GF RA   Birney E., Kumar S., Krainer A.R. 
#=GF RL   Nucleic Acid Res 1993;21:5803-5816.
#=GF DR   PROSITE; PDOC00030;
#=GF DR   SCOP; 1sxl; sf;
#=GF DR   MIM; 152700;
#=GF DR   MIM; 109090;
#=GF DR   HOMSTRAD; rrm;
#=GF DC   The following Pfam-B families contain sequences that according to Prodom
#=GF DC   are members of this Pfam-A family.
#=GF DR   PFAMB; PB001386;
#=GF DR   PFAMB; PB001539;
#=GF DR   PFAMB; PB002431;
#=GF DR   PFAMB; PB003624;
#=GF DR   PFAMB; PB005894;
#=GF DR   PFAMB; PB013606;
#=GF DR   PFAMB; PB016829;
#=GF DR   PFAMB; PB018975;
#=GF DR   PFAMB; PB019177;
#=GF DR   PFAMB; PB020714;
#=GF DR   PFAMB; PB021686;
#=GF DR   PFAMB; PB021998;
#=GF DR   PFAMB; PB026500;
#=GF DR   PFAMB; PB030976;
#=GF DR   PFAMB; PB034566;
#=GF DR   PFAMB; PB035948;
#=GF DR   PFAMB; PB038743;
#=GF DR   PFAMB; PB040629;
#=GF DR   PFAMB; PB056790;
#=GF DR   PFAMB; PB057545;
#=GF DR   PFAMB; PB058793;
#=GF DR   PFAMB; PB060078;
#=GF DR   PFAMB; PB060583;
#=GF DR   PFAMB; PB063375;
#=GF DR   PFAMB; PB074535;
#=GF DR   PFAMB; PB076854;
#=GF DR   PFAMB; PB080687;
#=GF DR   PFAMB; PB086034;
#=GF DR   PFAMB; PB086818;
#=GF DR   PFAMB; PB092687;
#=GF DR   PFAMB; PB095757;
#=GF DR   PFAMB; PB097655;
#=GF DR   PFAMB; PB106206;
#=GF DR   PFAMB; PB110433;
#=GF DR   PFAMB; PB120339;
#=GF DR   PFAMB; PB121973;
#=GF DR   PFAMB; PB129966;
#=GF DR   PFAMB; PB150546;
#=GF DR   PFAMB; PB153066;
#=GF DR   PFAMB; PB168984;
#=GF DR   PFAMB; PB169340;
#=GF DR   PFAMB; PB170125;
#=GF DR   PFAMB; PB170679;
#=GF DR   PFAMB; PB170741;
#=GF DR   PFAMB; PB170843;
#=GF DR   PFAMB; PB170925;
#=GF DR   PFAMB; PB171421;
#=GF DR   PFAMB; PB171438;
#=GF DR   PFAMB; PB171726;
#=GF DR   PFAMB; PB172371;
#=GF DR   PFAMB; PB172690;
#=GF DR   PFAMB; PB172737;
#=GF DR   PFAMB; PB173457;
#=GF DR   PFAMB; PB173738;
#=GF DR   PFAMB; PB173755;
#=GF DR   PFAMB; PB174169;
#=GF DR   PFAMB; PB174932;
#=GF DR   PFAMB; PB175170;
#=GF DR   PFAMB; PB175198;
#=GF DR   PFAMB; PB175338;
#=GF DR   PFAMB; PB176185;
#=GF DR   PFAMB; PB176927;
#=GF DR   PFAMB; PB177040;
#=GF DR   PFAMB; PB177301;
#=GF DR   PFAMB; PB177632;
#=GF DR   PFAMB; PB178096;
#=GF DR   PFAMB; PB178198;
#=GF DR   PFAMB; PB178250;
#=GF DR   PFAMB; PB178407;
#=GF DR   PFAMB; PB179951;
#=GF DR   PFAMB; PB180991;
#=GF DR   PFAMB; PB182298;
#=GF DR   PFAMB; PB182360;
#=GF DR   PFAMB; PB182522;
#=GF DR   INTERPRO; IPR000504;
#=GF CC   The RRM motif is probably diagnostic of an RNA binding protein.
#=GF CC   RRMs are found in a variety of RNA binding proteins, including 
#=GF CC   various hnRNP proteins, proteins implicated in regulation 
#=GF CC   of alternative splicing, and protein components
#=GF CC   of snRNPs. The motif also appears in a few single stranded
#=GF CC   DNA binding proteins. 
#=GF CC   The RRM structure consists of four strands
#=GF CC   and two helices arranged in an alpha/beta sandwich, with 
#=GF CC   a third helix present during RNA binding in some cases
#=GF CC   The C-terminal beta strand (4th strand) and final helix are hard 
#=GF CC   to align and have been omitted in the SEED alignment
#=GF CC   The LA proteins (Swiss:P05455) have a N terminus rrm which is
#=GF CC   included in the seed. There is a second region towards the
#=GF CC   C terminus that has some features of a rrm but does not 
#=GF CC   appear to have the important structural core of a rrm.
#=GF CC   The LA proteins (Swiss:P05455) are one of the main autoantigens
#=GF CC   in Systemic lupus erythematosus (SLE), an autoimmune disease.
#=GF SQ   79
#=GS GBP2_YEAST/221-291   AC P25555.1
#=GS ROC3_NICSY/99-170    AC P19682.1
#=GS ROC5_NICSY/116-187   AC P19684.1
#=GS ROC5_NICSY/219-290   AC P19684.1
#=GS TIA1_HUMAN/108-179   AC P31483.2
#=GS PUB1_YEAST/164-235   AC P32588.3
#=GS NAM8_YEAST/165-237   AC Q00539.2
#=GS RT19_ARATH/33-104    AC P39697.2
#=GS NSR1_YEAST/170-241   AC P27476.1
#=GS PES4_YEAST/93-164    AC P39684.2
#=GS NOP4_YEAST/28-98     AC P37838.1
#=GS PABP_SCHPO/263-333   AC P31209.2
#=GS PABP_DROME/92-162    AC P21187.3
#=GS PABP_DROME/185-256   AC P21187.3
#=GS CSTF2_HUMAN/18-89    AC P33240.1
#=GS CSTF2_HUMAN/18-89    DR PDB; 1p1t A; 18-89;
#=GS RNA15_YEAST/20-91    AC P25299.1
#=GS SGN1_YEAST/66-136    AC P40561.1
#=GS IST3_YEAST/33-104    AC P40565.1
#=GS NSR1_YEAST/269-340   AC P27476.1
#=GS IF4B_HUMAN/98-168    AC P23588.1
#=GS IF4B_HUMAN/98-168    DR PDB; 1wi8 A; 98-168;
#=GS ELAV_DROME/404-475   AC P16914.1
#=GS NOP3_YEAST/127-190   AC Q01560.1
#=GS GBP2_YEAST/124-193   AC P25555.1
#=GS HNRPC_HUMAN/18-82    AC P07910.4
#=GS HNRPC_HUMAN/18-82    DR PDB; 1wf2 A; 18-82;
#=GS TRA2_DROME/99-170    AC P19018.1
#=GS HNRPG_HUMAN/10-81    AC P38159.3
#=GS SFRS2_CHICK/16-87    AC P30352.1
#=GS SFRS3_MOUSE/12-78    AC P84104.1
#=GS SRR55_DROME/6-69     AC P26686.4
#=GS SFRS1_HUMAN/18-86    AC Q07955.2
#=GS SFRS1_HUMAN/18-86    DR PDB; 1x4a A; 26-94;
#=GS NONA_DROME/304-369   AC Q04047.2
#=GS RU17_DROME/104-175   AC P17133.2
#=GS PABP_DROME/4-75      AC P21187.3
#=GS ELAV4_HUMAN/48-119   AC P26378.1
#=GS ELAV4_HUMAN/48-119   DR PDB; 1fxl A; 41-112;
#=GS ELAV4_HUMAN/48-119   DR PDB; 1g2e A; 41-112;
#=GS SXL_DROME/127-198    AC P19339.1
#=GS SXL_DROME/127-198    DR PDB; 3sxl A; 127-198;
#=GS SXL_DROME/127-198    DR PDB; 1b7f B; 127-198;
#=GS SXL_DROME/127-198    DR PDB; 3sxl C; 127-198;
#=GS SXL_DROME/127-198    DR PDB; 1b7f A; 127-198;
#=GS SXL_DROME/127-198    DR PDB; 3sxl B; 127-198;
#=GS SXL_DROME/127-198    DR PDB; 2sxl ; 6-77;
#=GS ELAV_DROME/250-322   AC P16914.1
#=GS SXL_DROME/213-285    AC P19339.1
#=GS SXL_DROME/213-285    DR PDB; 3sxl A; 213-285;
#=GS SXL_DROME/213-285    DR PDB; 1b7f B; 213-285;
#=GS SXL_DROME/213-285    DR PDB; 3sxl C; 213-285;
#=GS SXL_DROME/213-285    DR PDB; 1sxl ; 16-88;
#=GS SXL_DROME/213-285    DR PDB; 1b7f A; 213-285;
#=GS SXL_DROME/213-285    DR PDB; 3sxl B; 213-285;
#=GS TIA1_HUMAN/216-281   AC P31483.2
#=GS TIA1_HUMAN/9-78      AC P31483.2
#=GS PUB1_YEAST/77-147    AC P32588.3
#=GS SQD_DROME/138-208    AC Q08473.3
#=GS ROA1_BOVIN/106-176   AC P09867.1
#=GS ROAA_MOUSE/161-231   AC Q99020.1
#=GS GRP10_BRANA/8-79     AC Q05966.1
#=GS ROAA_MOUSE/77-147    AC Q99020.1
#=GS SQD_DROME/58-128     AC Q08473.3
#=GS RB97D_DROME/34-104   AC Q02926.1
#=GS U2AF2_SCHPO/312-383  AC P36629.1
#=GS U2AF2_HUMAN/261-332  AC P26368.4
#=GS U2AF2_HUMAN/261-332  DR PDB; 2u2f A; 4-75;
#=GS PUB1_YEAST/343-408   AC P32588.3
#=GS RNP1_YEAST/37-109    AC P32385.2
#=GS GBP2_YEAST/351-421   AC P25555.1
#=GS NONA_DROME/378-448   AC Q04047.2
#=GS SFPQ_HUMAN/373-443   AC P23246.2
#=GS MODU_DROME/342-410   AC P13469.2
#=GS NUCL_CHICK/283-352   AC P15771.1
#=GS PES4_YEAST/305-374   AC P39684.2
#=GS YHH5_YEAST/315-384   AC P38760.1
#=GS YHC4_YEAST/348-415   AC P38741.1
#=GS MODU_DROME/422-484   AC P13469.2
#=GS PRP24_YEAST/212-284  AC P49960.1
#=GS MEI2_SCHPO/197-265   AC P08965.1
#=GS NOP4_YEAST/292-363   AC P37838.1
#=GS MODU_DROME/260-326   AC P13469.2
#=GS HNRPF_HUMAN/113-183  AC P52597.3
#=GS RU1A_YEAST/229-293   AC P32605.1
#=GS RU2B_HUMAN/153-220   AC P08579.1
#=GS SNRPA_HUMAN/210-276  AC P09012.3
#=GS SNRPA_HUMAN/210-276  DR PDB; 2u1a ; 17-83;
#=GS WHI3_YEAST/540-614   AC P34761.1
#=GS CPO_DROME/453-526    AC Q01617.3
#=GS NOP3_YEAST/202-270   AC Q01560.1
#=GS SFRS1_HUMAN/123-187  AC Q07955.2
#=GS PTBP1_HUMAN/186-253  AC P26599.1
#=GS PTBP1_HUMAN/186-253  DR PDB; 2adb A; 186-253;
#=GS PTBP1_HUMAN/186-253  DR PDB; 1sjr A; 49-116;
#=GS RNA12_YEAST/200-267  AC P32843.1
#=GS SSB1_YEAST/39-114    AC P10080.2
#=GS MODU_DROME/177-246   AC P13469.2
#=GS PRP24_YEAST/43-111   AC P49960.1
#=GS PRP24_YEAST/119-190  AC P49960.1
#=GS LA_HUMAN/113-182     AC P05455.2
#=GS LA_HUMAN/113-182     DR PDB; 1zh5 A; 113-182;
#=GS LA_HUMAN/113-182     DR PDB; 1zh5 B; 113-182;
#=GS LA_HUMAN/113-182     DR PDB; 1yty A; 113-182;
#=GS LA_HUMAN/113-182     DR PDB; 1yty B; 113-182;
#=GS LA_HUMAN/113-182     DR PDB; 1s79 A; 113-182;
GBP2_YEAST/221-291              VFIINL..PYSMNWQSLKDMFKE.CGHV.LRADVELD....FNGFSRGFGSVIYPTEDEMIRAIDTFNG.MEVEGRVLEV
ROC3_NICSY/99-170               LFVGNL..PYDIDSEGLAQLFQQ.AGVV.EIAEVIYN...RETDRSRGFGFVTMSTVEEADKAVELYSQ.YDLNGRLLTV
ROC5_NICSY/116-187              LYVGNL..PFSMTSSQLSEIFAE.AGTV.ANVEIVYD...RVTDRSRGFAFVTMGSVEEAKEAIRLFDG.SQVGGRTVKV
ROC5_NICSY/219-290              LYVANL..SWALTSQGLRDAFAD.QPGF.MSAKVIYD...RSSGRSRGFGFITFSSAEAMNSALDTMNE.VELEGRPLRL
TIA1_HUMAN/108-179              VFVGDL..SPQITTEDIKAAFAP.FGRI.SDARVVKD...MATGKSKGYGFVSFFNKWDAENAIQQMGG.QWLGGRQIRT
PUB1_YEAST/164-235              LFVGDL..NVNVDDETLRNAFKD.FPSY.LSGHVMWD...MQTGSSRGYGFVSFTSQDDAQNAMDSMQG.QDLNGRPLRI
NAM8_YEAST/165-237              IFVGDL..APNVTESQLFELFINRYAST.SHAKIVHD...QVTGMSKGYGFVKFTNSDEQQLALSEMQG.VFLNGRAIKV
RT19_ARATH/33-104               LYIGGL..SPGTDEHSLKDAFSS.FNGV.TEARVMTN...KVTGRSRGYGFVNFISEDSANSAISAMNG.QELNGFNISV
NSR1_YEAST/170-241              IFVGRL..SWSIDDEWLKKEFEH.IGGV.IGARVIYE...RGTDRSRGYGYVDFENKSYAEKAIQEMQG.KEIDGRPINC
PES4_YEAST/93-164               LFIGDL..HETVTEETLKGIFKK.YPSF.VSAKVCLD...SVTKKSLGHGYLNFEDKEEAEKAMEELNY.TKVNGKEIRI
NOP4_YEAST/28-98                LFVRSI..PQDVTDEQLADFFSN.FAPI.KHAVVVKD....TNKRSRGFGFVSFAVEDDTKEALAKARK.TKFNGHILRV
PABP_SCHPO/263-333              VYIKNL..DTEITEQEFSDLFGQ.FGEI.TSLSLVKD....QNDKPRGFGFVNYANHECAQKAVDELND.KEYKGKKLYV
PABP_DROME/92-162               VFIKNL..DRAIDNKAIYDTFSA.FGNI.LSCKVATD....EKGNSKGYGFVHFETEEAANTSIDKVNG.MLLNGKKVYV
PABP_DROME/185-256              VYVKNF..TEDFDDEKLKEFFEP.YGKI.TSYKVMSK....EDGKSKGFGFVAFETTEAAEAAVQALNGKDMGEGKSLYV
CSTF2_HUMAN/18-89               VFVGNI..PYEATEEQLKDIFSE.VGPV.VSFRLVYD...RETGKPKGYGFCEYQDQETALSAMRNLNG.REFSGRALRV
#=GR CSTF2_HUMAN/18-89    SS    EEE-S-..-TT--HHHHHHHHHT.TS-E.EEEEEEEE...TTTTEEEEEEEEEES-HHHHHHHHHHSSS.EEETTEEEEE
RNA15_YEAST/20-91               VYLGSI..PYDQTEEQILDLCSN.VGPV.INLKMMFD...PQTGRSKGYAFIEFRDLESSASAVRNLNG.YQLGSRFLKC
SGN1_YEAST/66-136               IFVGNI..TPDVTPEQIEDHFKD.CGQI.KRITLLYD...RNTGTPKGYGYIEFESPAYREKALQ.LNG.GELKGKKIAV
IST3_YEAST/33-104               IYIGNL..NRELTEGDILTVFSE.YGVP.VDVILSRD...ENTGESQGFAYLKYEDQRSTILAVDNLNG.FKIGGRALKI
NSR1_YEAST/269-340              LFLGNL..SFNADRDAIFELFAK.HGEV.VSVRIPTH...PETEQPKGFGYVQFSNMEDAKKALDALQG.EYIDNRPVRL
IF4B_HUMAN/98-168               AFLGNL..PYDVTEESIKEFFRG.LNIS..AVRLPR..EPSNPERLKGFGYAEFEDLDSLLSALS.LNE.ESLGNRRIRV
#=GR IF4B_HUMAN/98-168    SS    EEEES-..-TT--HHHHHHHT-S.S-EE..EEE--B..-SS-SSSB-S-EEEEESSHHHHHHHGG.GGS.-EETTEE-EE
ELAV_DROME/404-475              IFIYNL..APETEEAALWQLFGP.FGAV.QSVKIVKD...PTTNQCKGYGFVSMTNYDEAAMAIRALNG.YTMGNRVLQV
NOP3_YEAST/127-190              LFVRPF..PLDVQESELNEIFGP.FGPM.KEVKILN...........GFAFVEFEEAESAAKAIEEVHG.KSFANQPLEV
GBP2_YEAST/124-193              IFVRNL..TFDCTPEDLKELFGT.VGEV.VEADIIT.....SKGHHRGMGTVEFTKNESVQDAISKFDG.ALFMDRKLMV
HNRPC_HUMAN/18-82               VFIGNL.NTLVVKKSDVEAIFSK.YGKI.VGCSVHK...........GFAFVQYVNERNARAAVAGEDG.RMIAGQVLDI
#=GR HNRPC_HUMAN/18-82    SS    EEEEEE.-TTT--HHHHHHTTGG.GS-E.EEEEEET...........EEEEEEESSHHHHHHHHHTTSS.-EETTEE-EE
TRA2_DROME/99-170               IGVFGL..NTNTSQHKVRELFNK.YGPI.ERIQMVID...AQTQRSRGFCFIYFEKLSDARAAKDSCSG.IEVDGRRIRV
HNRPG_HUMAN/10-81               LFIGGL..NTETNEKALEAVFGK.YGRI.VEVLLMKD...RETNKSRGFAFVTFESPADAKDAARDMNG.KSLDGKAIKV
SFRS2_CHICK/16-87               LKVDNL..TYRTSPDTLRRVFEK.YGRV.GDVYIPRD...RYTKESRGFAFVRFHDKRDAEDAMDAMDG.AVLDGRELRV
SFRS3_MOUSE/12-78               VYVGNL..GNNGNKTELERAFGY.YGPL.RSVWVARN........PPGFAFVEFEDPRDAADAVRELDG.RTLCGCRVRV
SRR55_DROME/6-69                VYVGGL..PYGVRERDLERFFKG.YGRT.RDILIKN...........GYGFVEFEDYRDADDAVYELNG.KELLGERVVV
SFRS1_HUMAN/18-86               IYVGNL..PPDIRTKDIEDVFYK.YGAI.RDIDLKN......RRGGPPFAFVEFEDPRDAEDAVYGRDG.YDYDGYRLRV
#=GR SFRS1_HUMAN/18-86    SS    EEES--..TT--HHHHHHHHHTT.S-EE.EEEE--S......SSSS--EEEEES-HHHHHHHHHHHTT-.EETTEE-EEE
NONA_DROME/304-369              LYVGNL..TNDITDDELREMFKP.YGEI.SEIFSNLD.........KNFTFLKVDYHPNAEKAKRALDG.SMRKGRQLRV
RU17_DROME/104-175              LFIARI..NYDTSESKLRREFEF.YGPI.KKIVLIHD...QESGKPKGYAFIEYEHERDMHAAYKHADG.KKIDSKRVLV
PABP_DROME/4-75                 LYVGDL..PQDVNESGLFDKFSS.AGPV.LSIRVCRD...VITRRSLGYAYVNFQQPADAERALDTMNF.DLVRNKPIRI
ELAV4_HUMAN/48-119              LIVNYL..PQNMTQEEFRSLFGS.IGEI.ESCKLVRD...KITGQSLGYGFVNYIDPKDAEKAINTLNG.LRLQTKTIKV
#=GR ELAV4_HUMAN/48-119   SS    EEEES-..-TT--HHHHHHHHHT.TS-E.EEEEEEE-...TTT--EEEEEEEEESSHHHHHHHHHHHTT.-EETTEE-EE
SXL_DROME/127-198               LIVNYL..PQDMTDRELYALFRA.IGPI.NTCRIMRD...YKTGYSFGYAFVDFTSEMDSQRAIKVLNG.ITVRNKRLKV
#=GR SXL_DROME/127-198    SS    EEEES-..-TT--HHHHHHHHHT.TS-E.EEEEEEEE...SSSTEEECEEEEEESSHHHHHHHHHHHTT.-EETTEE-EE
ELAV_DROME/250-322              LYVSGL..PKTMTQQELEAIFAP.FGAI.ITSRILQN..AGNDTQTKGVGFIRFDKREEATRAIIALNG.TTPSSCTDPI
SXL_DROME/213-285               LYVTNL..PRTITDDQLDTIFGK.YGSI.VQKNILRD...KLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLS
#=GR SXL_DROME/213-285    SS    EEEES-..-TTS-HHHHHHHHGC.CS-E.EEEEEEE-...TTT--EEEEEEEEESSHHHHHHHHHHHST-S-TTSSS--E
TIA1_HUMAN/216-281              VYCGGV..TSGLTEQLMRQTFSP.FGQI.MEIRVFPD.........KGYSFVRFNSHESAAHAIVSVNG.TTIEGHVVKC
TIA1_HUMAN/9-78                 LYVGNL..SRDVTEALILQLFSQ.IGPC.KNCKMIMD.....TAGNDPYCFVEFHEHRHAAAALAAMNG.RKIMGKEVKV
PUB1_YEAST/77-147               LYVGNL..DKAITEDILKQYFQV.GGPI.ANIKIMID....KNNKNVNYAFVEYHQSHDANIALQTLNG.KQIENNIVKI
SQD_DROME/138-208               IFVGGL..TTEISDEEIKTYFGQ.FGNI.VEVEMPFD...KQKSQRKGFCFITFDSEQVVTDLLK.TPK.QKIAGKEVDV
ROA1_BOVIN/106-176              IFVGGI..KEDTEEHHLRDYFEQ.YGKI.EVIEIMTD...RGSGKKRGFAFVTFDDHDSVDKIVI.QKY.HTVNGHNCEV
ROAA_MOUSE/161-231              IFVGGL..NPEATEEKIREYFGQ.FGEI.EAIELPID...PKLNKRRGFVFITFKEEDPVKKVLE.KKF.HTVSGSKCEI
GRP10_BRANA/8-79                CFVGGL..AWATGDAELERTFSQ.FGEV.IDSKIIND...RETGRSRGFGFVTFKDEKSMKDAIDEMNG.KELDGRTITV
ROAA_MOUSE/77-147               MFVGGL..SWDTSKKDLKDYFTK.FGEV.VDCTIKMD...PNTGRSRGFGFILFKDSSSVEKVLD.QKE.HRLDGRVIDP
SQD_DROME/58-128                LFVGGL..SWETTEKELRDHFGK.YGEI.ESINVKTD...PQTGRSRGFAFIVFTNTEAIDKVSA.ADE.HIINSKKVDP
RB97D_DROME/34-104              LFIGGL..APYTTEENLKLFYGQ.WGKV.VDVVVMRD...AATKRSRGFGFITYTKSLMVDRAQE..NRPHIIDGKTVEA
U2AF2_SCHPO/312-383             IYISNL..PLNLGEDQVVELLKP.FGDL.LSFQLIKN...IADGSSKGFCFCEFKNPSDAEVAISGLDG.KDTYGNKLHA
U2AF2_HUMAN/261-332             LFIGGL..PNYLNDDQVKELLTS.FGPL.KAFNLVKD...SATGLSKGYAFCEYVDINVTDQAIAGLNG.MQLGDKKLLV
#=GR U2AF2_HUMAN/261-332  SS    EEEE--..-SS--SHHHHHHHTS.SS-E.EEEEEE--...-SSS----EEEEEESSSHHHHHHHHTSSS.---SSS--EE
PUB1_YEAST/343-408              AYIGNI..PHFATEADLIPLFQN.FGFI.LDFKHYPE.........KGCCFIKYDTHEQAAVCIVALAN.FPFQGRNLRT
RNP1_YEAST/37-109               LYVGNL..PKNCRKQDLRDLFEPNYGKI.TINMLKKK...PLKKPLKRFAFIEFQEGVNLKKVKEKMNG.KIFMNEKIVI
GBP2_YEAST/351-421              IYCSNL..PFSTARSDLFDLFGP.IGKI.NNAELKP....QENGQPTGVAVVEYENLVDADFCIQKLNN.YNYGGCSLQI
NONA_DROME/378-448              LRVSNL..TPFVSNELLYKSFEI.FGPI.ERASITVD....DRGKHMGEGIVEFAKKSSASACLRMCNE.KCFFLTASLR
SFPQ_HUMAN/373-443              LSVRNL..SPYVSNELLEEAFSQ.FGPI.ERAVVIVD....DRGRSTGKGIVEFASKPAARKAFERCSE.GVFLLTTTPR
MODU_DROME/342-410              LVVENVGKHESYSSDALEKIFKK.FGDV.EEIDVVC........SKAVLAFVTFKQSDAATKALAQLDG.KTVNKFEWKL
NUCL_CHICK/283-352              LFVKNL..TPTKDYEELRTAIKEFFGKK..NLQVSEV....RIGSSKRFGYVDFLSAEDMDKALQ.LNG.KKLMGLEIKL
PES4_YEAST/305-374              IFIKNL..PTITTRDDILNFFSE.VGPI.KSIYLSN.....ATKVKYLWAFVTYKNSSDSEKAIKRYNN.FYFRGKKLLV
YHH5_YEAST/315-384              ILVKNL..PSDTTQEEVLDYFST.IGPI.KSVFISEK.....QANTPHKAFVTYKNEEESKKAQKCLNK.TIFKNHTIWV
YHC4_YEAST/348-415              IFVGQL..DKETTREELNRRFST.HGKI.QDINLIFK.......PTNIFAFIKYETEEAAAAALESENH.AIFLNKTMHV
MODU_DROME/422-484              ILVTNL..TSDATEADLRKVFND.SGEI.ESIIMLG...........QKAVVKFKDDEGFCKSFL.ANE.SIVNNAPIFI
PRP24_YEAST/212-284             IMIRNL.STELLDENLLRESFEG.FGSI.EKINIPAG..QKEHSFNNCCAFMVFENKDSAERALQ.MNR.SLLGNREISV
MEI2_SCHPO/197-265              LFVTNL..PRIVPYATLLELFSK.LGDV.KGIDTSSL.......STDGICIVAFFDIRQAIQAAKSLRSQRFFNDRLLYF
NOP4_YEAST/292-363              VFVRNV..PYDATEESLAPHFSK.FGSV.KYALPVID...KSTGLAKGTAFVAFKDQYTYNECIKNAPA.AGSTSLLIGD
MODU_DROME/260-326              VVVGLI..GPNITKDDLKTFFEK.VAPV.EAVTISSN.......RLMPRAFVRLASVDDIPKALK.LHS.TELFSRFITV
HNRPF_HUMAN/113-183             VRLRGL..PFGCTKEEIVQFFSG.LEIVPNGITLPVD....PEGKITGEAFVQFASQELAEKALG.KHK.ERIGHRYIEV
RU1A_YEAST/229-293              LLIQNL..PSGTTEQLLSQILGN.EALV..EIRLVSV.........RNLAFVEYETVADATKIKNQLGS.TYKLQNNDVT
RU2B_HUMAN/153-220              LFLNNL..PEETNEMMLSMLFNQ.FPGF.KEVRLVPG........RHDIAFVEFENDGQAGAARDALQGFKITPSHAMKI
SNRPA_HUMAN/210-276             LFLTNL..PEETNELMLSMLFNQ.FPGF.KEVRLVPG........RHDIAFVEFDNEVQAGAARDALQG.FKITQNNAMK
#=GR SNRPA_HUMAN/210-276  SS    EEE---..SS--HHHHHHHHHTS.TTEE.EEE--TTT........SSEEEEEES-HHHHHHHHHHTTT-.-SSSS-----
WHI3_YEAST/540-614              LYVGNL..PSDATEQELRQLFSG.QEGF.RRLSFRNKNTTSNGHSHGPMCFVEFDDVSFATRALAELYG.RQLPRSTVSS
CPO_DROME/453-526               LFVSGL..PMDAKPRELYLLFRA.YEGY.EGSLLKV..TSKNGKTASPVGFVTFHTRAGAEAAKQDLQGVRFDPDMPQTI
NOP3_YEAST/202-270              ITMKNL..PEGCSWQDLKDLARE.NSLE.TTFSSVN......TRDFDGTGALEFPSEEILVEALERLNN.IEFRGSVITV
SFRS1_HUMAN/123-187             VVVSGL..PPSGSWQDLKDHMRE.AGDV.CYADVYRD..........GTGVVEFVRKEDMTYAVRKLDN.TKFRSHEGET
PTBP1_HUMAN/186-253             IIVENL..FYPVTLDVLHQIFSK.FGTV...LKIIT.....FTKNNQFQALLQYADPVSAQHAKLSLDG.QNIYNACCTL
#=GR PTBP1_HUMAN/186-253  SS    EEC-S-..-STTHHHHHHHHHTT.TS-E...EEEEE.....EECTTEEEEEEEES-HHHHHHHHHHHCC.B-SSSTTSEE
RNA12_YEAST/200-267             IVIKFQ..GPALTEEEIYSLFRR.YGTI...IDIFP.....PTAANNNVAKVRYRSFRGAISAKNCVSG.IEIHNTVLHI
SSB1_YEAST/39-114               IFIGNV..AHECTEDDLKQLFVEEFGDE.VSVEIPIKEHTDGHIPASKHALVKFPTKIDFDNIKENYDT.KVVKDREIHI
MODU_DROME/177-246              VFVTNL..PNEYLHKDLVALFAK.FGRL.SALQRFTN......LNGNKSVLIAFDTSTGAEAVLQAKPKALTLGDNVLSV
PRP24_YEAST/43-111              VLVKNL..PKSYNQNKVYKYFKH.CGPI.IHVDVAD.....SLKKNFRFARIEFARYDGALAAIT.KTH.KVVGQNEIIV
PRP24_YEAST/119-190             LWMTNF..PPSYTQRNIRDLLQD.INVVALSIRLPSL....RFNTSRRFAYIDVTSKEDARYCVEKLNG.LKIEGYTLVT
LA_HUMAN/113-182                VYIKGF..PTDATLDDIKEWLED.KGQV.LNIQMRR....TLHKAFKGSIFVVFDSIESAKKFVE.TPG.QKYKETDLLI
#=GR LA_HUMAN/113-182     SS    EEEE--..-TT--HHHHHHHHCT.SS-E.EEEEEEE....-TTTSEEEEEEEEESSHHHHHHHHH.SSS.-EETTEE-EE
#=GC SS_cons                    EEEESE..TTTTHHHHHHHHHTT.TSEE.EEEEEEEE..STTTTSEEEEEEEEESSHHHHHHHHHHHSS.EEETTEEEEE
#=GC seq_cons                   laVssL..s.ssoccpLcphFpp.aGtl.hshplhtc.....ptpscGauFVpFpspcsAppAlpthsu.pplpu+plpl
//
