LOCUS       NM_014491               2472 bp    mRNA    linear   PRI 28-MAY-2006
DEFINITION  Homo sapiens forkhead box P2 (FOXP2), transcript variant 1, mRNA.
ACCESSION   NM_014491
VERSION     NM_014491.1  GI:17017962
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2472)
  AUTHORS   Sanjuan,J., Tolosa,A., Gonzalez,J.C., Aguilar,E.J., Perez-Tur,J.,
            Najera,C., Molto,M.D. and de Frutos,R.
  TITLE     Association between FOXP2 polymorphisms and schizophrenia with
            auditory hallucinations
  JOURNAL   Psychiatr. Genet. 16 (2), 67-72 (2006)
   PUBMED   16538183
  REMARK    GeneRIF: The single nucleotide polymorphism rs2396753 appears to
            confer vulnerability to schizophrenia with auditory hallucinations.
REFERENCE   2  (bases 1 to 2472)
  AUTHORS   Stroud,J.C., Wu,Y., Bates,D.L., Han,A., Nowick,K., Paabo,S.,
            Tong,H. and Chen,L.
  TITLE     Structure of the forkhead domain of FOXP2 bound to DNA
  JOURNAL   Structure 14 (1), 159-166 (2006)
   PUBMED   16407075
  REMARK    GeneRIF: Disease-causing mutations in FOXP2 map either to the DNA
            binding surface or the domain-swapping dimer interface,
            functionally corroborating the crystal structure.
REFERENCE   3  (bases 1 to 2472)
  AUTHORS   Benitez-Burraco,A.
  TITLE     [FOXP2: from the specific disorder to the molecular biology of
            language. I. Aetiological, neuroanatomical, neurophysiological and
            molecular aspects]
  JOURNAL   Rev Neurol 40 (11), 671-682 (2005)
   PUBMED   15948071
  REMARK    Review article
            GeneRIF: Review. FOXP2 codes for a CNS transcriptional repressor,
            expressed in the basal ganglia, cortex, cerebellum & the thalamus,
            involved in thalamic-cortical-striatal circuits for motor planning
            & learning. Its loss causes specific language impairment.
REFERENCE   4  (bases 1 to 2472)
  AUTHORS   MacDermot,K.D., Bonora,E., Sykes,N., Coupe,A.M., Lai,C.S.,
            Vernes,S.C., Vargha-Khadem,F., McKenzie,F., Smith,R.L., Monaco,A.P.
            and Fisher,S.E.
  TITLE     Identification of FOXP2 truncation as a novel cause of
            developmental speech and language deficits
  JOURNAL   Am. J. Hum. Genet. 76 (6), 1074-1080 (2005)
   PUBMED   15877281
  REMARK    GeneRIF: Truncation of FOXP2 is the cause of developmental speech
            and language deficits.
REFERENCE   5  (bases 1 to 2472)
  AUTHORS   Vargha-Khadem,F., Gadian,D.G., Copp,A. and Mishkin,M.
  TITLE     FOXP2 and the neuroanatomy of speech and language
  JOURNAL   Nat. Rev. Neurosci. 6 (2), 131-138 (2005)
   PUBMED   15685218
  REMARK    Review article
            GeneRIF: a mutation in FOXP2 had been found in a family with a
            speech and language disorder.
REFERENCE   6  (bases 1 to 2472)
  AUTHORS   Gong,X., Jia,M., Ruan,Y., Shuang,M., Liu,J., Wu,S., Guo,Y.,
            Yang,J., Ling,Y., Yang,X. and Zhang,D.
  TITLE     Association between the FOXP2 gene and autistic disorder in Chinese
            population
  JOURNAL   Am. J. Med. Genet. B Neuropsychiatr. Genet. 127 (1), 113-116 (2004)
   PUBMED   15108192
  REMARK    GeneRIF: Findings suggest that the FOXP2 gene may be involved in
            the pathogenesis of autism in Chinese population.
REFERENCE   7  (bases 1 to 2472)
  AUTHORS   Teramitsu,I., Kudo,L.C., London,S.E., Geschwind,D.H. and White,S.A.
  TITLE     Parallel FoxP1 and FoxP2 expression in songbird and human brain
            predicts functional interaction
  JOURNAL   J. Neurosci. 24 (13), 3152-3163 (2004)
   PUBMED   15056695
  REMARK    GeneRIF: FOXP1 and FOXP2 expression patterns in human fetal brain
            are strikingly similar to those in the songbird, including
            localization to subcortical structures that function in
            sensorimotor integration and the control of skilled, coordinated
            movement
REFERENCE   8  (bases 1 to 2472)
  AUTHORS   Banerjee-Basu,S. and Baxevanis,A.D.
  TITLE     Structural analysis of disease-causing mutations in the P-subfamily
            of forkhead transcription factors
  JOURNAL   Proteins 54 (4), 639-647 (2004)
   PUBMED   14997560
  REMARK    GeneRIF: impact of disease-causing missense mutations on the
            three-dimensional structure, stability, and surface electrostatic
            charge distribution of the forkhead domains is examined
REFERENCE   9  (bases 1 to 2472)
  AUTHORS   Li,S., Weidenfeld,J. and Morrisey,E.E.
  TITLE     Transcriptional and DNA binding activity of the Foxp1/2/4 family is
            modulated by heterotypic and homotypic protein interactions
  JOURNAL   Mol. Cell. Biol. 24 (2), 809-822 (2004)
   PUBMED   14701752
  REMARK    GeneRIF: complex regulatory mechanism underlying Foxp1, Foxp2, and
            Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the
            first Fox proteins reported whose activity is regulated by homo-
            and heterodimerization
REFERENCE   10 (bases 1 to 2472)
  AUTHORS   Liegeois,F., Baldeweg,T., Connelly,A., Gadian,D.G., Mishkin,M. and
            Vargha-Khadem,F.
  TITLE     Language fMRI abnormalities associated with FOXP2 gene mutation
  JOURNAL   Nat. Neurosci. 6 (11), 1230-1237 (2003)
   PUBMED   14555953
  REMARK    GeneRIF: This experiment findings suggest that the FOXP2 gene is
            critically involved in the development of the neural systems that
            mediate speech and language.
REFERENCE   11 (bases 1 to 2472)
  AUTHORS   Lai,C.S., Gerrelli,D., Monaco,A.P., Fisher,S.E. and Copp,A.J.
  TITLE     FOXP2 expression during brain development coincides with adult
            sites of pathology in a severe speech and language disorder
  JOURNAL   Brain 126 (PT 11), 2455-2462 (2003)
   PUBMED   12876151
  REMARK    GeneRIF: FOXP2/foxp2 is expressed in several structures in
            developing human/mouse brain including cortical plate, basal
            ganglia, thalamus, inferior olives and cerebellum. These data
            suggest a conserved mammalian role in development of motor-related
            neural circuits
REFERENCE   12 (bases 1 to 2472)
  AUTHORS   Hillier,L.W., Fulton,R.S., Fulton,L.A., Graves,T.A., Pepin,K.H.,
            Wagner-McPherson,C., Layman,D., Maas,J., Jaeger,S., Walker,R.,
            Wylie,K., Sekhon,M., Becker,M.C., O'Laughlin,M.D., Schaller,M.E.,
            Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E., Cordes,M.,
            Du,H., Sun,H., Edwards,J., Bradshaw-Cordum,H., Ali,J., Andrews,S.,
            Isak,A., Vanbrunt,A., Nguyen,C., Du,F., Lamar,B., Courtney,L.,
            Kalicki,J., Ozersky,P., Bielicki,L., Scott,K., Holmes,A.,
            Harkins,R., Harris,A., Strong,C.M., Hou,S., Tomlinson,C.,
            Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Leonard,S., Rohlfing,T.,
            Rock,S.M., Tin-Wollam,A.M., Abbott,A., Minx,P., Maupin,R.,
            Strowmatt,C., Latreille,P., Miller,N., Johnson,D., Murray,J.,
            Woessner,J.P., Wendl,M.C., Yang,S.P., Schultz,B.R., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Nelson,J.O., Berkowicz,N., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Bedell,J.A.,
            Mardis,E.R., Clifton,S.W., Chissoe,S.L., Marra,M.A., Raymond,C.,
            Haugen,E., Gillett,W., Zhou,Y., James,R., Phelps,K., Iadanoto,S.,
            Bubb,K., Simms,E., Levy,R., Clendenning,J., Kaul,R., Kent,W.J.,
            Furey,T.S., Baertsch,R.A., Brent,M.R., Keibler,E., Flicek,P.,
            Bork,P., Suyama,M., Bailey,J.A., Portnoy,M.E., Torrents,D.,
            Chinwalla,A.T., Gish,W.R., Eddy,S.R., McPherson,J.D., Olson,M.V.,
            Eichler,E.E., Green,E.D., Waterston,R.H. and Wilson,R.K.
  TITLE     The DNA sequence of human chromosome 7
  JOURNAL   Nature 424 (6945), 157-164 (2003)
   PUBMED   12853948
REFERENCE   13 (bases 1 to 2472)
  AUTHORS   O'Brien,E.K., Zhang,X., Nishimura,C., Tomblin,J.B. and Murray,J.C.
  TITLE     Association of specific language impairment (SLI) to the region of
            7q31
  JOURNAL   Am. J. Hum. Genet. 72 (6), 1536-1543 (2003)
   PUBMED   12721956
  REMARK    GeneRIF: Genetic factors for regulation of common language
            impairment appear to reside in the vicinity of FOXP2.
REFERENCE   14 (bases 1 to 2472)
  AUTHORS   Scherer,S.W., Cheung,J., MacDonald,J.R., Osborne,L.R.,
            Nakabayashi,K., Herbrick,J.A., Carson,A.R., Parker-Katiraee,L.,
            Skaug,J., Khaja,R., Zhang,J., Hudek,A.K., Li,M., Haddad,M.,
            Duggan,G.E., Fernandez,B.A., Kanematsu,E., Gentles,S.,
            Christopoulos,C.C., Choufani,S., Kwasnicka,D., Zheng,X.H., Lai,Z.,
            Nusskern,D., Zhang,Q., Gu,Z., Lu,F., Zeesman,S., Nowaczyk,M.J.,
            Teshima,I., Chitayat,D., Shuman,C., Weksberg,R., Zackai,E.H.,
            Grebe,T.A., Cox,S.R., Kirkpatrick,S.J., Rahman,N., Friedman,J.M.,
            Heng,H.H., Pelicci,P.G., Lo-Coco,F., Belloni,E., Shaffer,L.G.,
            Pober,B., Morton,C.C., Gusella,J.F., Bruns,G.A., Korf,B.R.,
            Quade,B.J., Ligon,A.H., Ferguson,H., Higgins,A.W., Leach,N.T.,
            Herrick,S.R., Lemyre,E., Farra,C.G., Kim,H.G., Summers,A.M.,
            Gripp,K.W., Roberts,W., Szatmari,P., Winsor,E.J., Grzeschik,K.H.,
            Teebi,A., Minassian,B.A., Kere,J., Armengol,L., Pujana,M.A.,
            Estivill,X., Wilson,M.D., Koop,B.F., Tosi,S., Moore,G.E.,
            Boright,A.P., Zlotorynski,E., Kerem,B., Kroisel,P.M., Petek,E.,
            Oscier,D.G., Mould,S.J., Dohner,H., Dohner,K., Rommens,J.M.,
            Vincent,J.B., Venter,J.C., Li,P.W., Mural,R.J., Adams,M.D. and
            Tsui,L.C.
  TITLE     Human chromosome 7: DNA sequence and biology
  JOURNAL   Science 300 (5620), 767-772 (2003)
   PUBMED   12690205
REFERENCE   15 (bases 1 to 2472)
  AUTHORS   Zhang,J., Webb,D.M. and Podlaha,O.
  TITLE     Accelerated protein evolution and origins of human-specific
            features: Foxp2 as an example
  JOURNAL   Genetics 162 (4), 1825-1835 (2002)
   PUBMED   12524352
  REMARK    GeneRIF: A survey of a diverse group of placental mammals reveals
            the uniqueness of the human FOXP2 sequence and a population genetic
            analysis indicates possible adaptive selection behind the
            accelerated evolution.
REFERENCE   16 (bases 1 to 2472)
  AUTHORS   Enard,W., Przeworski,M., Fisher,S.E., Lai,C.S., Wiebe,V.,
            Kitano,T., Monaco,A.P. and Paabo,S.
  TITLE     Molecular evolution of FOXP2, a gene involved in speech and
            language
  JOURNAL   Nature 418 (6900), 869-872 (2002)
   PUBMED   12192408
  REMARK    GeneRIF: Human FOXP2 contains changes in amino-acid coding and a
            pattern of nucleotide polymorphism, which strongly suggest that
            this gene has been the target of selection during recent human
            evolution.
REFERENCE   17 (bases 1 to 2472)
  AUTHORS   Bruce,H.A. and Margolis,R.L.
  TITLE     FOXP2: novel exons, splice variants, and CAG repeat length
            stability
  JOURNAL   Hum. Genet. 111 (2), 136-144 (2002)
   PUBMED   12189486
REFERENCE   18 (bases 1 to 2472)
  AUTHORS   Newbury,D.F., Bonora,E., Lamb,J.A., Fisher,S.E., Lai,C.S.,
            Baird,G., Jannoun,L., Slonims,V., Stott,C.M., Merricks,M.J.,
            Bolton,P.F., Bailey,A.J. and Monaco,A.P.
  CONSRTM   International Molecular Genetic Study of Autism Consortium
  TITLE     FOXP2 is not a major susceptibility gene for autism or specific
            language impairment
  JOURNAL   Am. J. Hum. Genet. 70 (5), 1318-1327 (2002)
   PUBMED   11894222
  REMARK    GeneRIF: FOXP2 is not a major susceptibility gene for autism or
            specific language impairment
REFERENCE   19 (bases 1 to 2472)
  AUTHORS   Lai,C.S., Fisher,S.E., Hurst,J.A., Vargha-Khadem,F. and Monaco,A.P.
  TITLE     A forkhead-domain gene is mutated in a severe speech and language
            disorder
  JOURNAL   Nature 413 (6855), 519-523 (2001)
   PUBMED   11586359
  REMARK    GeneRIF: FOXP2 is disrupted by a translocation in CS, a child with
            severe speech/language disorder. Moreover, a point mutation,
            altering a critical residue of the forkhead domain, segregates with
            speech/language deficits in all 15 affected members of family KE.
REFERENCE   20 (bases 1 to 2472)
  AUTHORS   Lai,C.S., Fisher,S.E., Hurst,J.A., Levy,E.R., Hodgson,S., Fox,M.,
            Jeremiah,S., Povey,S., Jamison,D.C., Green,E.D., Vargha-Khadem,F.
            and Monaco,A.P.
  TITLE     The SPCH1 region on human 7q31: genomic characterization of the
            critical interval and localization of translocations associated
            with speech and language disorder
  JOURNAL   Am. J. Hum. Genet. 67 (2), 357-368 (2000)
   PUBMED   10880297
REFERENCE   21 (bases 1 to 2472)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum. Genet. 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF337817.
            
            Summary: This gene encodes an evolutionarily conserved
            transcription factor expressed in fetal and adult brain. This
            transcription factor is a member of the forkhead/winged-helix (FOX)
            family of transcription factors, and contains a FOX DNA-binding
            domain and a large polyglutamine tract. Members of the FOX family
            of transcription factors are regulators of embryogenesis. The
            product of this gene is thought to be required for proper
            development of speech and language regions of the brain during
            embryogenesis. Although a point mutation in this gene has been
            associated with the KE pedigree segregating developmental verbal
            dyspraxia, no association between mutations in this gene and
            another speech disorder, autism, has been found. Four alternative
            transcripts encoding three different isoforms have been identified.
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform.
FEATURES             Location/Qualifiers
     source          1..2472
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q31"
     gene            1..2472
                     /gene="FOXP2"
                     /note="synonyms: SPCH1, CAGH44, TNRC10, DKFZp686H1726"
                     /db_xref="GeneID:93986"
                     /db_xref="HGNC:13875"
                     /db_xref="HPRD:HPRD_05611"
                     /db_xref="MIM:605317"
     CDS             151..2298
                     /gene="FOXP2"
                     /go_component="nucleus [goid 0005634] [evidence IEA]"
                     /go_function="zinc ion binding [goid 0008270] [evidence
                     IEA]"
                     /go_function="metal ion binding [goid 0046872] [evidence
                     IEA]"
                     /go_function="nucleic acid binding [goid 0003676]
                     [evidence IEA]"
                     /go_function="sequence-specific DNA binding [goid 0043565]
                     [evidence IEA]"
                     /go_function="transcription factor activity [goid 0003700]
                     [evidence IEA]"
                     /go_process="transcription [goid 0006350] [evidence IEA]"
                     /go_process="regulation of transcription, DNA-dependent
                     [goid 0006355] [evidence IEA]"
                     /note="isoform I is encoded by transcript variant 1;
                     trinucleotide repeat containing 10; forkhead/winged-helix
                     transcription factor; speech and language disorder 1; CAG
                     repeat protein 44"
                     /codon_start=1
                     /product="forkhead box P2 isoform I"
                     /protein_id="NP_055306.1"
                     /db_xref="GI:17017963"
                     /db_xref="CCDS:CCDS5760.1"
                     /db_xref="GeneID:93986"
                     /db_xref="HGNC:13875"
                     /db_xref="HPRD:HPRD_05611"
                     /db_xref="MIM:605317"
                     /translation="MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEV
                     STVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQ
                     QMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQ
                     QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQ
                     QQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGV
                     HSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHE
                     ETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLE
                     IQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTP
                     TAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFT
                     YATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVE
                     NVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLL
                     SNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAED
                     EDCPMSLVTTANHSPELEDDREIEEEPLSEDLE"
     misc_feature    604..723
                     /gene="FOXP2"
                     /note="Region: polyglutamine tract"
     misc_feature    1660..1878
                     /gene="FOXP2"
                     /note="Forkhead (FH), also known as a 'winged helix';
                     Region: FH"
                     /db_xref="CDD:28941"
     misc_feature    408^409
                     /gene="FOXP2"
                     /note="Region: location of alternate exons 3a and 3b"
ORIGIN      
        1 agtgagctag cttctgagtt ttcccttctt tttatactgt tttctgtgct ggcttttttg
       61 aatcttccta atttttcatc tctttaacaa actcctatga agttgaaacc gggaagtttg
      121 ctctaacatt tccagagaag gtattaagtc atgatgcagg aatctgcgac agagacaata
      181 agcaacagtt caatgaatca aaatggaatg agcactctaa gcagccaatt agatgctggc
      241 agcagagatg gaagatcaag tggtgacacc agctctgaag taagcacagt agaactgctg
      301 catctgcaac aacagcaggc tctccaggca gcaagacaac ttcttttaca gcagcaaaca
      361 agtggattga aatctcctaa gagcagtgat aaacagagac cactgcaggt gcctgtgtca
      421 gtggccatga tgactcccca ggtgatcacc cctcagcaaa tgcagcagat ccttcagcaa
      481 caagtcctgt ctcctcagca gctacaagcc cttctccaac aacagcaggc tgtcatgctg
      541 cagcagcaac aactacaaga gttttacaag aaacagcaag agcagttaca tcttcagctt
      601 ttgcagcagc agcagcaaca gcagcagcag caacaacagc agcaacaaca gcagcagcaa
      661 caacaacaac aacagcagca acaacagcag cagcagcagc aacagcagca gcagcagcaa
      721 cagcatcctg gaaagcaagc gaaagagcag cagcagcagc agcagcagca acagcaattg
      781 gcagcccagc agcttgtctt ccagcagcag cttctccaga tgcaacaact ccagcagcag
      841 cagcatctgc tcagccttca gcgtcaggga ctcatctcca ttccacctgg ccaggcagca
      901 cttcctgtcc aatcgctgcc tcaagctggc ttaagtcctg ctgagattca gcagttatgg
      961 aaagaagtga ctggagttca cagtatggaa gacaatggca ttaaacatgg agggctagac
     1021 ctcactacta acaattcctc ctcgactacc tcctccaaca cttccaaagc atcaccacca
     1081 ataactcatc attccatagt gaatggacag tcttcagttc taagtgcaag acgagacagc
     1141 tcgtcacatg aggagactgg ggcctctcac actctctatg gccatggagt ttgcaaatgg
     1201 ccaggctgtg aaagcatttg tgaagatttt ggacagtttt taaagcacct taacaatgaa
     1261 cacgcattgg atgaccgaag cactgctcag tgtcgagtgc aaatgcaggt ggtgcaacag
     1321 ttagaaatac agctttctaa agaacgcgaa cgtcttcaag caatgatgac ccacttgcac
     1381 atgcgaccct cagagcccaa accatctccc aaacctctaa atctggtgtc tagtgtcacc
     1441 atgtcgaaga atatgttgga gacatcccca cagagcttac ctcaaacccc taccacacca
     1501 acggccccag tcaccccgat tacccaggga ccctcagtaa tcaccccagc cagtgtgccc
     1561 aatgtgggag ccatacgaag gcgacattca gacaaataca acattcccat gtcatcagaa
     1621 attgccccaa actatgaatt ttataaaaat gcagatgtca gacctccatt tacttatgca
     1681 actctcataa ggcaggctat catggagtca tctgacaggc agttaacact taatgaaatt
     1741 tacagctggt ttacacggac atttgcttac ttcaggcgta atgcagcaac ttggaagaat
     1801 gcagtacgtc ataatcttag cctgcacaag tgttttgttc gagtagaaaa tgttaaagga
     1861 gcagtatgga ctgtggatga agtagaatac cagaagcgaa ggtcacaaaa gataacagga
     1921 agtccaacct tagtaaaaaa tatacctacc agtttaggct atggagcagc tcttaatgcc
     1981 agtttgcagg ctgccttggc agagagcagt ttacctttgc taagtaatcc tggactgata
     2041 aataatgcat ccagtggcct actgcaggcc gtccacgaag acctcaatgg ttctctggat
     2101 cacattgaca gcaatggaaa cagtagtccg ggctgctcac ctcagccgca catacattca
     2161 atccacgtca aggaagagcc agtgattgca gaggatgaag actgcccaat gtccttagtg
     2221 acaacagcta atcacagtcc agaattagaa gacgacagag agattgaaga agagccttta
     2281 tctgaagatc tggaatgaga actgacttgt gaaacctcag cgtgaaggga catatcactg
     2341 accttcataa ccactccaca accatgaata tttgacaaat ttttactgtg actatttatt
     2401 aagcatggat aaaggagaca gccctaaagg aacttactaa gccagccctt tgggattcag
     2461 taccaacagg ca
//
