ENTRY           CCHU  #type complete
TITLE           cytochrome c [validated] - human
ORGANISM        #formal_name Homo sapiens #common_name man
DATE            24-Apr-1984 #sequence_revision 30-Sep-1991 #text_change
                28-Jul-2000
ACCESSIONS      A31764; A05676; I55192; A00001
REFERENCE       A31764
   #authors     Evans, M.J.; Scarpulla, R.C.
   #journal     Proc. Natl. Acad. Sci. U.S.A. (1988) 85:9625-9629
   #title       The human somatic cytochrome c gene: two classes of
                processed pseudogenes demarcate a period of rapid molecular
                evolution.
   #cross-references MUID:89071748
   #accession   A31764
      ##molecule_type DNA
      ##residues 1-105 ##label EVA
      ##cross-references GB:M22877; NID:g181241; PIDN:AAA35732.1;
                PID:g181242
REFERENCE       A05676
   #authors     Matsubara, H.; Smith, E.L.
   #journal     J. Biol. Chem. (1963) 238:2732-2753
   #title       Human heart cytochrome c. Chymotryptic peptides, tryptic
                peptides, and the complete amino acid sequence.
   #accession   A05676
      ##molecule_type protein
      ##residues 2-28;29-46;47-100;101-105 ##label MATS
REFERENCE       A00001
   #authors     Matsubara, H.; Smith, E.L.
   #journal     J. Biol. Chem. (1962) 237:3575-3576
   #title       The amino acid sequence of human heart cytochrome c.
   #contents    annotation
   #note        66-Leu is found in 10% of the molecules in pooled protein
REFERENCE       I55192
   #authors     Tanaka, Y.; Ashikari, T.; Shibano, Y.; Amachi, T.;
                Yoshizumi, H.; Matsubara, H.
   #journal     J. Biochem. (1988) 103:954-961
   #title       Construction of a human cytochrome c gene and its functional
                expression in Saccharomyces cerevisiae.
   #cross-references MUID:89008207
   #accession   I55192
      ##status translated from GB/EMBL/DDBJ
      ##molecule_type mRNA
      ##residues 78-105 ##label RES
      ##cross-references GB:D00265; NID:g2897691; PIDN:BAA00187.1;
                PID:g219557
GENETICS
   #introns     57/1
CLASSIFICATION  #superfamily cytochrome c; cytochrome c homology
KEYWORDS        acetylated amino end; chromoprotein; electron transfer;
                heme; iron; metalloprotein; mitochondrion; oxidative
                phosphorylation; polymorphism; respiratory chain
FEATURE
   2-105               #product cytochrome c #status experimental #label
                       MAT\
   5-99                #domain cytochrome c homology #label CYC\
   2                   #modified_site acetylated amino end (Gly) (in mature
                       form) #status experimental\
   15,18               #binding_site heme (Cys) (covalent) #status
                       experimental\
   19,81               #binding_site heme iron (His, Met) (axial ligands)
                       #status predicted
SUMMARY         #length 105  #molecular-weight 11749  #checksum 3247
SEQUENCE
                 5        10        15        20        25        30
       1 M G D V E K G K K I F I M K C S Q C H T V E K G G K H K T G
      31 P N L H G L F G R K T G Q A P G Y S Y T A A N K N K G I I W
      61 G E D T L M E Y L E N P K K Y I P G T K M I F V G I K K K E
      91 E R A D L I A Y L K K A T N E
///
