FSL

### find_the_biggest

find_the_biggest is a command line utility that performs hard segmentation of a seed region on the basis of outputs of probtrackx when classification targets are being used.

The output of Connectivity-based seed classification is a single volume for each target mask, named seeds_to_{target} where {target} is replaced by the file name of the relevant target mask. In these output images, the value of each voxel within the seed mask is the number of samples seeded from that voxel reaching the target mask. find_the_biggest classifies seed voxels according to the target mask with which they show the highest probability of connection. It is run as follows:

find_the_biggest list_of_volumes outputname Where the list of volumes is the outputs of Connectivity-based seed classification (i.e., files named seeds_to_target1 etc etc).

The example on the right uses probtrackx and find_the_biggest to perform hard segmentation of the thalamus on the basis of its connections to cortex.