#!/bin/sh

#   bet - wrapper script for lots of different bet functionality
#
#   Stephen Smith, FMRIB Image Analysis Group
#   SIENA eye cleanup option by Marco Battaglini and Nicola De Stefano, Siena
#
#   Copyright (C) 2005-2007 University of Oxford
#
#   Part of FSL - FMRIB's Software Library
#   http://www.fmrib.ox.ac.uk/fsl
#   fsl@fmrib.ox.ac.uk
#   
#   Developed at FMRIB (Oxford Centre for Functional Magnetic Resonance
#   Imaging of the Brain), Department of Clinical Neurology, Oxford
#   University, Oxford, UK
#   
#   
#   LICENCE
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#   FMRIB Software Library, Release 4.0 (c) 2007, The University of
#   Oxford (the "Software")
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#   innovation@isis.ox.ac.uk quoting reference DE/1112.

# {{{ Usage()

Usage() {
    cat <<EOF

Usage:    bet <input> <output> [options]

Main bet2 options:
  -o          generate brain surface outline overlaid onto original image
  -m          generate binary brain mask
  -s          generate approximate skull image
  -n          don't generate segmented brain image output
  -f <f>      fractional intensity threshold (0->1); default=0.5; smaller values give larger brain outline estimates
  -g <g>      vertical gradient in fractional intensity threshold (-1->1); default=0; positive values give larger brain outline at bottom, smaller at top
  -r <r>      head radius (mm not voxels); initial surface sphere is set to half of this
  -c <x y z>  centre-of-gravity (voxels not mm) of initial mesh surface.
  -t          apply thresholding to segmented brain image and mask
  -e          generates brain surface as mesh in .vtk format

Variations on default bet2 functionality (mutually exclusive options):
  (default)   just run bet2
  -R          robust brain centre estimation (iterates BET several times)
  -S          eye & optic nerve cleanup (can be useful in SIENA)
  -B          bias field & neck cleanup (can be useful in SIENA)
  -Z          improve BET if FOV is very small in Z (by temporarily padding end slices)
  -F          apply to 4D FMRI data (uses -f 0.3 and dilates brain mask slightly)
  -A          run bet2 and then betsurf to get additional skull and scalp surfaces (includes registrations)
  -A2 <T2>    as with -A, when also feeding in non-brain-extracted T2 (includes registrations)

Miscellaneous options:
  -v          verbose (switch on diagnostic messages)
  -h          display this help, then exits
  -d          debug (don't delete temporary intermediate images)

EOF
    exit 1
}

# }}}
# {{{ get_dims()

get_dims() {
    xdim=`${FSLDIR}/bin/fslval $1 dim1 | sed 's/-//g'`
    ydim=`${FSLDIR}/bin/fslval $1 dim2 | sed 's/-//g'`
    zdim=`${FSLDIR}/bin/fslval $1 dim3 | sed 's/-//g'`
    xpixdim=`${FSLDIR}/bin/fslval $1 pixdim1 | sed 's/-//g'`
    ypixdim=`${FSLDIR}/bin/fslval $1 pixdim2 | sed 's/-//g'`
    zpixdim=`${FSLDIR}/bin/fslval $1 pixdim3 | sed 's/-//g'`
    #echo $xdim $ydim $zdim $xpixdim $ypixdim $zpixdim
}

# }}}
# {{{ find_centre_in_mm()

# find_centre_in_mm() {
#     centre=`${FSLDIR}/bin/fslstats $1 -l 0.001 -C`
#     x=`echo $centre $xpixdim | awk '{print "10 k " $1 " " $4 " * p"}' | dc -`
#     y=`echo $centre $ypixdim | awk '{print "10 k " $2 " " $4 " * p"}' | dc -`
#     z=`echo $centre $zpixdim | awk '{print "10 k " $3 " " $4 " * p"}' | dc -`
#     #echo $x $y $z
# }

# }}}
# {{{ find_centre_in_voxels()

find_centre_in_voxels() {
    centre=`${FSLDIR}/bin/fslstats $1 -l 0.001 -C`
    x=`echo $centre | awk '{print $1}'`
    y=`echo $centre | awk '{print $2}'`
    z=`echo $centre | awk '{print $3}'`
    #echo $x $y $z
}

# }}}

# {{{ parse IN and OUT options

[ "$2" = "" ] && Usage
IN=`${FSLDIR}/bin/remove_ext $1`
OUT=`${FSLDIR}/bin/remove_ext $2`
shift 2
if [ `${FSLDIR}/bin/imtest $IN` = 0 ] ; then
    echo ""
    echo "Error: input image $IN not valid"
    echo ""
    exit 1
fi

# }}}
# {{{ setup variable defaults

debug=0
verbose=0
variation=0
bet2opts=""

# }}}
# {{{ parse options

while [ _$1 != _ ] ; do
    if [ $1 = -o ] || [ $1 = -m ] || [ $1 = -s ] || [ $1 = -n ] || [ $1 = -t ] || [ $1 = -e ] ; then
        bet2opts="$bet2opts $1"
        shift
    elif [ $1 = -f ] || [ $1 = -g ] || [ $1 = -r ] ; then
	[ "$2" = "" ] && Usage
        bet2opts="$bet2opts $1 $2"
        shift 2
    elif [ $1 = -c ] ; then
	[ "$4" = "" ] && Usage
        bet2opts="$bet2opts $1 $2 $3 $4"
        shift 4
    elif [ $1 = -R ] ; then
	variation=1
        shift
    elif [ $1 = -S ] ; then
	variation=2
        shift
    elif [ $1 = -Z ] ; then
	variation=3
        shift
    elif [ $1 = -F ] ; then
	variation=4
        shift
    elif [ $1 = -A ] ; then
	variation=5
        shift
    elif [ $1 = -A2 ] ; then
	[ "$2" = "" ] && Usage
	variation=6
	IN2=$2
        shift 2
    elif [ $1 = -B ] ; then
	variation=7
        shift
    elif [ $1 = -v ] ; then
	verbose=1
	bet2opts="$bet2opts -v"
        shift
    elif [ $1 = -d ] ; then
	debug=1
        shift
    else
	Usage
    fi
done

if [ $verbose = 1 ] ; then
    echo IN=$IN
    echo OUT=$OUT
    echo bet2opts="${bet2opts}"
    echo verbose=$verbose
    echo debug=$debug
    echo variation=$variation
fi

# }}}
# {{{ process variations

if [ $variation = 0 ] ; then
    ${FSLDIR}/bin/bet2 $IN $OUT $bet2opts
elif [ $variation = 1 ] ; then
    # {{{ BET robust

bet2opts=`echo $bet2opts | sed 's/-n//g'`
get_dims $IN

i=1
while [ $i -gt 0 ] ; do
    #echo $i
    if [ $i = 1 ] ; then
	${FSLDIR}/bin/bet2 $IN $OUT $bet2opts
	find_centre_in_voxels $OUT
    else
	${FSLDIR}/bin/bet2 $IN $OUT $bet2opts -c $x $y $z
	ox=$x; oy=$y; oz=$z;
	find_centre_in_voxels $OUT
	diffsq=`echo "0 k $ox $x - 2 ^ $oy $y - 2 ^ + $oz $z - 2 ^ + 1 / p" | dc -`
	#echo $diffsq
	if [ $diffsq -lt 1 ] || [ $i -gt 10 ] ; then
	    i=_10
	fi
    fi
    i=`echo "$i 1 + p" | dc -`
done

# }}}
elif [ $variation = 2 ] ; then
    # {{{ SIENA eye cleanup

#### get the raw brain and skull images
${FSLDIR}/bin/bet2 $IN ${OUT}_tmp_betraw -s $bet2opts

#### run betpremask (keep intermediate files around using -d) and feed it into bet
${FSLDIR}/bin/standard_space_roi $IN ${OUT}_tmp_premask -b -d
${FSLDIR}/bin/bet2 ${OUT}_tmp_premask ${OUT}_tmp_premask_bet -n -m -f 0.4 $bet2opts

#### bring eye mask from standard space into native and dilate, mostly in 2D and then invert
${FSLDIR}/bin/flirt -ref $IN -in ${FSLDIR}/data/standard/MNI152_T1_2mm_eye_mask -applyxfm -init ${OUT}_tmp_premask_tmp_to_std_inv.mat -datatype float -out ${OUT}_tmp_eye_mask
${FSLDIR}/bin/fslmaths ${OUT}_tmp_eye_mask -thr 0.5 -bin -dilF -kernel 2D -dilF -dilF -dilF -dilF -dilF -dilF -dilF ${OUT}_tmp_eyes7dil -odt short
${FSLDIR}/bin/fslmaths ${OUT}_tmp_eyes7dil -mul -1 -add 1 ${OUT}_tmp_eyes7dil_inv

#### mask original brain mask with inverted-eye-mask, ADD betpremask_bet_mask and X by original brain
${FSLDIR}/bin/fslmaths ${OUT}_tmp_betraw -bin -mas ${OUT}_tmp_eyes7dil_inv -add ${OUT}_tmp_premask_bet_mask -bin -mul ${OUT}_tmp_betraw ${OUT}_tmp_prebrain

#### find upper threshold used to delete eyes
Mean=`${FSLDIR}/bin/fslstats ${OUT}_tmp_prebrain -M`
SD=`${FSLDIR}/bin/fslstats ${OUT}_tmp_prebrain -S`
thr=`echo "10 k 3.5 $SD * $Mean + p" | dc -`

#### apply threshold and a little morphology (twice) to cleanup further and produce final brain image
${FSLDIR}/bin/fslmaths ${OUT}_tmp_prebrain -uthr $thr -bin -ero -dilF -dilF -ero -mul ${OUT}_tmp_prebrain -uthr $thr -bin -kernel 2D -ero -dilF -mul ${OUT}_tmp_betraw $OUT
${FSLDIR}/bin/fslmaths $OUT -bin ${OUT}_mask

#### remove eyes from original skull to produce final skull image
${FSLDIR}/bin/fslmaths ${OUT}_tmp_eyes7dil -ero -kernel 2D -ero -mul -1 -add 1 ${OUT}_tmp_eyes5dil_inv
${FSLDIR}/bin/fslmaths ${OUT}_tmp_betraw_skull -mas ${OUT}_tmp_eyes5dil_inv ${OUT}_skull

# }}}
elif [ $variation = 3 ] ; then
    # {{{ small FOV in Z

MINZFOV=100.0
get_dims $IN

npad=`echo "$MINZFOV $zpixdim / $zdim - 2 / 1 + p" | dc -`

if [ $npad -le 0 ] ; then
    echo "Image already has a greater Z FOV than $MINZFOV so not using padding"
    ${FSLDIR}/bin/bet2 $IN $OUT $bet2opts
    exit
fi

${FSLDIR}/bin/fslroi $IN ${OUT}_tmp_bottom 0 $xdim 0 $ydim 0 1
${FSLDIR}/bin/fslroi $IN ${OUT}_tmp_top    0 $xdim 0 $ydim `echo "$zdim 1 - p" | dc -` 1

n=1
while [ $n -le $npad ] ; do
    bottomlist="$bottomlist ${OUT}_tmp_bottom"
    toplist="$toplist ${OUT}_tmp_top"
    n=`echo "$n 1 + p" | dc -`
done

${FSLDIR}/bin/fslmerge -z ${OUT}_tmp $bottomlist $IN $toplist

${FSLDIR}/bin/bet2 ${OUT}_tmp $OUT $bet2opts

for f in `imglob ${OUT}*` ; do
    ${FSLDIR}/bin/fslroi $f $f 0 $xdim 0 $ydim $npad $zdim
done

# }}}
elif [ $variation = 4 ] ; then
    # {{{ FMRI

${FSLDIR}/bin/fslroi $IN ${OUT}_tmp 0 1
${FSLDIR}/bin/bet2 ${OUT}_tmp ${OUT}_tmp_brain -m -n -f 0.3 $bet2opts
${FSLDIR}/bin/fslmaths ${OUT}_tmp_brain_mask -dilF ${OUT}_mask
${FSLDIR}/bin/fslmaths $IN -mas ${OUT}_mask $OUT

# }}}
elif [ $variation = 5 ] ; then
    # {{{ bet2 + betsurf (T1 only)

# register T1 to standard space
${FSLDIR}/bin/flirt -ref ${FSLDIR}/data/standard/MNI152_T1_2mm -in $IN -omat ${OUT}_tmp_T1_to_std.mat

# run brain extraction and save brain mesh
${FSLDIR}/bin/bet2 $IN $OUT -e $bet2opts

# find other surfaces
${FSLDIR}/bin/betsurf --t1only -o -m -s $IN ${OUT}_mesh.vtk ${OUT}_tmp_T1_to_std.mat $OUT

# }}}
elif [ $variation = 6 ] ; then
    # {{{ bet2 + betsurf (T1 & T2)

# register T2 to T1
${FSLDIR}/bin/flirt -in $IN2 -ref $IN -out ${OUT}_tmp_T2_to_T1 -omat ${OUT}_tmp_T2_to_T1.mat -interp sinc

# register T1 to standard space
${FSLDIR}/bin/flirt -ref ${FSLDIR}/data/standard/MNI152_T1_2mm -in $IN -omat ${OUT}_tmp_T1_to_std.mat

# run brain extraction and save brain mesh
${FSLDIR}/bin/bet2 $IN $OUT -e $bet2opts

# find other surfaces
${FSLDIR}/bin/betsurf -o -m -s $IN ${OUT}_tmp_T2_to_T1 ${OUT}_mesh.vtk ${OUT}_tmp_T1_to_std.mat $OUT

# }}}
elif [ $variation = 7 ] ; then
    # {{{ SIENA bias field & neck cleanup

#### run betpremask
${FSLDIR}/bin/standard_space_roi $IN ${OUT}_tmp_premask -b -d

#### run FAST to get bias field
${FSLDIR}/bin/fast -b ${OUT}_tmp_premask >/dev/null 2>&1

#### apply bias correction to original
${FSLDIR}/bin/fslmaths $IN -div ${OUT}_tmp_premask_bias ${OUT}_tmp_unbiased

#### re-run betpremask
${FSLDIR}/bin/standard_space_roi ${OUT}_tmp_unbiased ${OUT}_tmp_unbiased_premask -b -d

#### re-run in robust mode
${FSLDIR}/bin/bet ${OUT}_tmp_unbiased_premask $OUT -m $bet2opts -R -d

# }}}
fi

# }}}
# {{{ cleanup temporary files

if [ $debug = 0 ] ; then
    /bin/rm -f ${OUT}_tmp*
fi

# }}}

